Hypermutation
Mostrando 1-12 de 159 artigos, teses e dissertações.
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1. Advances in Cryptococcus genomics: insights into the evolution of pathogenesis
Cryptococcus species are the causative agents of cryptococcal meningitis, a significant source of mortality in immunocompromised individuals. Initial work on the molecular epidemiology of this fungal pathogen utilized genotyping approaches to describe the genetic diversity and biogeography of two species, Cryptococcus neoformans and Cryptococcus gattii. Whol
Mem. Inst. Oswaldo Cruz. Publicado em: 19/02/2018
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2. Função de avaliação dinâmica em algoritmos genéticos aplicados na predição de estruturas tridimensionais de proteínas / Genetic Algorithms with Dynamic Fitness Functions Applied to Tridimensional Protein Structure Prediction
The protein structure prediction can be seen as an optimization problem where given an amino acid sequence, the tertiary protein structure must be found amongst many possible by obtaining energy functions minima. Many researchers have been proposing Evolutionary Computation strategies to find tridimensional structures of proteins; however results are not alw
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/09/2012
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3. Influência dos polimofismos de nucleotídeo único (SNPs) da APOBEC3G na dinâmica populacional da infecção pelo HIV-1 / Influence of single nucleotide polymorphisms of APOBEC3G in the population dynamic in the HIV-1 infection
APOBEC3G (A3G) has been described as a cellular factor that inhibits replication of HIV-1. During reverse transcription, A3G promotes deamination of cytidine to uracil in the minus strand viral DNA, inducing hypermutation of guanines to adenines in plus strand DNA. The HIV-1 counters this effect by the activity of the viral protein Vif, which counteracts A3G
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/04/2011
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4. Redundancy and recombination in the Echinococcus AgB multigene family : is there any similarity with protozoan contigency genes?
Numerous genetic variants of the Echinococcus antigen B (AgB) are encountered within a single metacestode. This could be a reflection of gene redundancy or the result of a somatic hypermutation process. We evaluate the complexity of the AgB multigene family by characterizing the upstream promoter regions of the 4 already known genes (EgAgB1-EgAgB4) and evalu
Publicado em: 2011
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5. Prevalência de Pseudomonas aeruginosa hipermutante em pacientes com fibrose cística e associação com resistência antimicrobiana em condições plantônicas e em biofilme
Foram avaliados 528 isolados clínicos de Pseudomonas aeruginosa de 131 pacientes fibrocísticos atendidos em um centro de referência em fibrose cística (FC) durante o período de 2005 a 2008. 135 isolados clínicos (25,6%) apresentaram subpopulação hipermutante (isolados com altas taxas de mutações) utilizando teste modificado de suscetibilidade aos a
Publicado em: 2011
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6. Técnicas de controle da diversidade de populações em algoritmos genéticos para determinação de estruturas de proteínas / Control of the Population Diversity in Genetic Algorithms for the Determination of Protein Structures
Recentemente, pesquisadores têm proposto o uso de Algoritmos Genéticos (AGs) para a determinação da estrutura tridimensional de proteínas. No entanto, este é um problema difícil para um AG tradicional, pois na maioria das vezes ocorre a convergência prematura das soluções para ótimos locais. Isto ocorre porque o uso de mecanismos de seleção no A
Publicado em: 2009
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7. Use of V H, D and J H immunoglobulin gene segments in Brazilian patients with chronic lymphocytic leukaemia (CLL)
Chronic lymphocytic leukaemia (CLL) is a haematological malignancy for which reliable prognostic markers are needed in view of its clinical heterogeneity. In approximately 50% of CLL patients, immunoglobulin (Ig) rearrangements are modified by somatic hypermutation (SHM), a process that represents a reliable prognostic indicator of favourable progression. In
Genetics and Molecular Biology. Publicado em: 2008
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8. Correlation between hypermutation and viral load in patients infected with human immunodeficiency virus type 1 (HIV-1) / Análise de correlação entre eventos de hipermutação e carga viral em pacientes infectados pelo vírus da imunodeficiência humana tipo 1(HIV-1).
INTRODUÇÃO: A substituição monótona de bases G → A no genoma do HIV-1 é observada desde a década de 1990, entretanto, apenas recentemente esse efeito foi atribuído às APOBECs (apolipoprotein B editing catalytic polypeptide) da imunidade inata. As APOBECs celulares atuam na deaminação de citidina a uridina na fita de DNA viral de polaridade n
Publicado em: 2008
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9. AplicaÃÃo de sistemas imunolÃgicos artificiais para prediÃÃo da estrutura de proteÃnas / Artificial immune systems aplication for protein structure prediction
This work presents hybrid Immune-based Systems to solve the Protein Folding Problem for the three-dimensional hydrofobic-Polar model (3D HP). The Protein Structure Prediction consists of finding the spacial arrangement of a proteinâs amino acids that has a minimal energy. The proposed methodology is focused on Artificial Immune Systems supported by but uses
Publicado em: 2007
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10. Genome-wide somatic hypermutation
DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially dangerous, it has been hypothesized that mutations do not occur throughout the genome but instead are actively targeted to the Ig loci. Here we challenge this longstanding and widely accepted hypothesis. We dem
National Academy of Sciences.
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11. Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.
Hypermutation of immunoglobulin genes is a key process in antibody diversification. Little is known about the mechanism, but the availability of rapid facile assays for monitoring immunoglobulin hypermutation would greatly aid the development of culture systems for hypermutating B cells as well as the screening for individuals deficient in the process. Here
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12. The reverse transcriptase model of somatic hypermutation.
The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL-6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of soma