Hydrophilic Drugs
Mostrando 1-12 de 42 artigos, teses e dissertações.
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1. Per-Aqueous Liquid Chromatography for the Separation of Polar Compounds Preparation and Characterization of Poly(ethylene oxide co dimethylsiloxane) Based Stationary Phase
Poly(ethylene oxide-co-dimethylsiloxane) was thermally immobilized on silica particles-Si(PEO)-to separate small polar compounds with water-rich mobile phases. Poly(ethylene oxide-co-dimethylsiloxane) content on Si(PEO) stationary phase was optimized using a central composite design. Infrared spectroscopy, scanning electron microscopy, and thermogravimetric
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Evaluating the discriminatory power of a dissolution assay for rosuvastatin calcium capsules: Solid-state properties and dissolution media
We propose to evaluate the dissolution properties of rosuvastatin calcium (ROSC) capsules in different media to characterize the discriminatory power of the assay method. Dissolution assays were performed in media with different pH, and including the surfactant sodium dodecyl sulfate (SDS). Several immediate-release formulations were manufactured using the c
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019
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3. Matéria Evaluation of zinc oxide nanoparticles influence on hydrophilic polymer matrix systems
ABSTRACT Hydrophilic polymer matrix systems (HPMSs) are a highly relevant tool for drugs delivery whose bioavailability is impaired by low hydrosolubility. Besides this, when associated with nanoparticles these systems can provide better control over release profile of the active drug, maintaining the posology. Since polyvinylpyrrolidone (PVP) and zinc oxide
Matéria (Rio J.). Publicado em: 06/12/2018
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4. Physical methods for topical skin drug delivery: concepts and applications
Topical drug delivery is an interesting approach to treat skin diseases and to avoid pain and low patient compliance in cases where a systemic delivery is required. However, the stratum corneum, which is the outermost skin layer, strongly protects the body from the entrance of substances, especially those hydrophilic. In this context, different physical meth
Braz. J. Pharm. Sci.. Publicado em: 08/11/2018
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5. Liposome and Their Applications in Cancer Therapy
ABSTRACT Liposomes, the vesicles of phospholipid bilayer, can encapsulate both hydrophilic and lipophilic drugs and protect them from degradation. Liposomes have been extensively studied and continue to create intense interest in research since their discovery in the mid-1960s. Since then, liposomes have been considered to be the most successful nanocarriers
Braz. arch. biol. technol.. Publicado em: 08/03/2016
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6. Planejamento, síntese e avaliação da atividade anti-T. cruzi de derivados furfurilidênicos com estruturas azometínica e oxadiazolínica / Design, synthesis, identification and anti-Trypanosoma cruzi activity evaluation of furfurylidene azomethine and oxadiazole derivatives
The search for alternative therapies for the treatment of Chagas disease presents great importance, since there are only two currently available drugs, nifurtimox and benznidazole. Both have considerable adverse effects and, in Brazil, is used only benznidazole. Nitro-heterocyclic compounds with activity against Trypanosoma cruzi, the causative agent of Chag
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2012
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7. Obtenção de membranas hidrofílicas a base de PVP (Poli N-vinil-2-pirrolidona) contendo alginato de sódio e nanocarga de pseudoboemita obtida pelo processo sol-gel
The use of hydrogels combined with various additives in tissue regeneration and wound scarring, injuries and burnings has been an option in treatments of difficult scarring, infected-bleeding wounds, burnings and other diseases whose treatments, moist and sterilized resources are required. The hydrogels based on poly (N-vinyl-2-pyrrolidone) are membranes tha
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/03/2011
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8. Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
Photodynamic therapy is a well-established and clinically approved treatment for several types of cancer. Antineoplastic photodynamic therapy is based on photosensitizers, i.e., drugs that absorb photons translating light energy into a chemical potential that damages tumor tissues. Despite the encouraging clinical results with the approved photosensitizers a
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-08
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9. Desenvolvimento e caracterização de nanopartículas lipídicas contendo topotecano / Development and characterization of lipid nanoparticles containing topotecan
O cloridrato de topotecano (TPT), derivado semi-sintético hidrofílico da camptotecina, é um fármaco antineoplásico inibidor da topoisomerase I. A encapsulação do TPT em nanocarreadores pode protegê-lo da inativação no pH plasmático, além de contornar o problema da resistência celular mediada pela glicoproteína-P (P-gp). No presente trabalho for
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/10/2010
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10. Síntese de meso-tetrafenilporfirinas com substituintes reativos no anel meso-fenil visando a obtenção de derivados porfirínicos catiônicos aquossolúveis
There is a considerable interest in the synthesis of water soluble porphyrins due to its use as models of biological systems, as drugs and as homogeneous catalysts in aqueous media. Within this context, this work describes the synthesis of meso-tetraphenylporphyrins with reactive groups on the meso-phenyl ring to generate trimethylarylammonium salts derivati
Publicado em: 2010
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11. Desenvolvimento e caracterização de nanopartículas lipídicas contendo topotecano / Development and characterization of lipid nanoparticles containing topotecan
O cloridrato de topotecano (TPT), derivado semi-sintético hidrofílico da camptotecina, é um fármaco antineoplásico inibidor da topoisomerase I. A encapsulação do TPT em nanocarreadores pode protegê-lo da inativação no pH plasmático, além de contornar o problema da resistência celular mediada pela glicoproteína-P (P-gp). No presente trabalho for
Publicado em: 2010
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12. Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview
Polymeric nanoparticle systems (nanocapsules and nanospheres) present potential applications as drug delivery systems. Nevertheless, their full applications have not been exploited due to their limited shelf life when stored in aqueous medium. Drying polymeric nanoparticles using spray-drying represents a promising platform to improve the physicochemical sta
Brazilian Journal of Physics. Publicado em: 2009-04