Human Pancreatic Islets
Mostrando 1-12 de 97 artigos, teses e dissertações.
-
1. The role of melatonin in diabetes: therapeutic implications
Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 path
Arch. Endocrinol. Metab.. Publicado em: 28/08/2015
-
2. O efeito pró-apoptótico de oligômeros da amilina humana não é potencializado pela lipotoxicidade em ilhotas pancreáticas de rato em cultura / The pro-apoptotic effect of human amylin oligomers is not potentiated by lipotoxicity in rat pancreatic islets in culture
The amyloid deposit is a common histopathological feature in patients with type 2 diabetes mellitus (T2DM) and it seems to be related to the pancreatic beta cell dysfunction characteristic of this disease. A study previously developed in our laboratory found that human amylin oligomers decrease mRNA expression of the glucose-dependent insulinotropic polypept
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2012
-
3. Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice
C57BL/6 mice develop signs and symptoms comparable, in part, to the human metabolic syndrome. The objective of the present study was to evaluate the effects of exercise training on carbohydrate metabolism, lipid profile, visceral adiposity, pancreatic islet alterations, and nonalcoholic fatty liver disease in C57BL/6 mice. Animals were fed one of two diets d
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
-
4. Obtention of human pancreatic islets for transplantation through an increase in cell mass and an immunoisolation with biocompatible microcapsules / Ilhotas pancreáticas humanas viáveis para o transplante através do aumento da massa de células e do imunoisolamento com microcápsulas biocompatíveis
Islet transplantation has been proposed as a promising therapeutic strategy for the cure of type 1 diabetes mellitus (DM), however, its application to all diabetic patients is still not possible due to the limited source of islets or β cells and to the need of an immunosuppressive treatment of the recipient to avoid graft rejection. The use of immunosup
Publicado em: 2009
-
5. Comparison of the effect of ganglioside GM1 and the Nerve Growth Factor (NGF) on the expression of receiver of high affinity for NGF, TrkA and insulin in isolated pancreatic islets of NOD mice (non obese diabetic) / Comparação dos efeitos do gangliosideo GM1 e do fator de crescimento neural (NGF) sobre a expressão de receptor de alta afinidade para NGF, TrkA e insulina em ilhotas pancreaticas isoladas de camundongos NOD (diabetico não obeso)
The non-obese diabetic mice (NOD) lineage is characterized by developing type 1 diabetes mellitus (DM-1) naturally, bearing a similarity to DM-1 in human beings. The spontaneous manifestation of diabetes is characterized by gradual infiltration in pancreatic islets by mononuclear cells lymphocytes T (CD4+ and CD8+) and destruction of the ß-cells producers o
Publicado em: 2008
-
6. Avaliação do estresse oxidativo em ilhotas pancreáticas humanas e em cultura de células INS-1E / Evaluation of oxidative stress in human pancreatic islets and INS-1E cells culture
Human pancreatic islet transplantation is considered a promising strategy to cure the cure Diabetes Mellitus type I. However, transplantation efficiency is dramatically affected by sub-optimum islet recovery in the isolation/purification procedure and islet viability after transplantation. Isolated pancreatic islets are obtained through collagenase perfusion
Publicado em: 2007
-
7. Efeito da variação do oxigênio sobre o perfil transcricional de ilhotas pancreáticas humanas em cultura / Effect of oxygen concentration variation on the transcriptional profile of cultured human pancreatic islets
Glicose e oxigênio desempenham um importante papel na regulação do metabolismo celular. Dada a importância de ambos no metabolismo - o primeiro como fonte de carbono preferencial da maior parte das células, e o segundo como aceptor final de elétrons na cadeia respiratória, em diversos organismos desenvolveram-se métodos adequados para detectar sua pr
Publicado em: 2007
-
8. Estudo dos efeitos imuno moduladores de gangliosideos na inflamação/expressão do diabetes mellitus autoimune em camundongo Nod-Uni
The beta cells destruction on diabetes type 1 autoimmune knowledge was derivative from NOD (diabetic non obese) mouse as experimental model, which have demonstrated great potential for drugs or immunotherapy s study. In this model, the diabetes manifestation occurs spontaneously like the observed in human, among 128-248 week of life. The prevalence could be
Publicado em: 2005
-
9. Kinetics of TNF-alpha and IFN-gamma mRNA expression in islets and spleen of NOD mice
Insulin-dependent diabetes mellitus is caused by autoimmune destruction of pancreatic ß cells. Non-obese diabetic (NOD) mice spontaneously develop diabetes similar to the human disease. Cytokines produced by islet-infiltrating mononuclear cells may be directly cytotoxic and can be involved in islet destruction coordinated by CD4+ and CD8+ cells. We utilized
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-11
-
10. Cloning and characterization of glucose-regulated genes in human pancreatic islets / "Clonagem e caracterização de genes regulados por glicose em ilhotas pancreáticas humanas"
Type 1 Diabetes mellitus (T1DM) is caused by autoimmune destruction of the insulin-producing pancreatic islet b-cells. Treatment is generally approached by daily subcutaneous injections of exogenous insulin. Nowadays, pancreatic islet transplantation is considered as an effective alternative treatment to insulin therapy. However, in order to reach insulin-in
Publicado em: 2002
-
11. Microencapsulation and tissue engineering as an alternative treatment of diabetes
In the 70's, pancreatic islet transplantation arose as an attractive alternative to restore normoglycemia; however, the scarcity of donors and difficulties with allotransplants, even under immunosuppressive treatment, greatly hampered the use of this alternative. Several materials and devices have been developed to circumvent the problem of islet rejection b
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-06
-
12. Estudo do efeito de gangliosideos sobre a incidencia e morbidade do diabetes mellitus em camundongos NOD/Uni (non-obese diabetic)
Diabetes mellitus type l(DM-l) is an autoimmune disease that results ITom destruction and dysfunction of pancreatic _-cells. This process, known as insulitis, is dependent on the presence of a mononuc1ear cells infiltrate in islets of Langerhans. Non obese diabetic (NOD) mouse is an experimental model of DM-l that develops spontaneous diabetes between the 4t
Publicado em: 2000