Homology Modeling
Mostrando 13-24 de 150 artigos, teses e dissertações.
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13. Modelagem molecular aplicada ao estudo de reações de inibição enzimática com aplicação potencial no controle de Leishmania amazonensis. 2010. / Applied molecular modeling to the enzymatic inhibition reactions study with Leishmania amazonensis controls potential application. 2010.
Parasitic protozoan diseases, transmitted by blood-feeding insects, constitute the worlds most widely spread human health problem. It is estimated that three million people suffer from a parasitic infection (mainly trypanosomatid and apicomplexan parasites), responsible for important human diseases. The compounds here studied constitute the amidines and the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/06/2010
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14. In silicio expression analysis of PKS genes isolated from Cannabis sativa L.
Cannabinoids, flavonoids, and stilbenoids have been identified in the annual dioecious plant Cannabis sativa L. Of these, the cannabinoids are the best known group of this plant's natural products. Polyketide synthases (PKSs) are responsible for the biosynthesis of diverse secondary metabolites, including flavonoids and stilbenoids. Biosynthetically, the can
Genetics and Molecular Biology. Publicado em: 29/10/2010
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15. Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge
A cDNA encoding chalcone synthase (CHS), the key enzyme in flavonoid biosynthesis, was isolated from hairy root cultures of Scutellaria viscidula Bunge by rapid amplification of cDNA ends (RACE). The full-length cDNA of S. viscidula CHS, designated as Svchs (GenBank accession no. EU386767), was 1649 bp with a 1170 bp open reading frame (ORF) that corresponde
Genetics and Molecular Biology. Publicado em: 23/04/2010
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16. Estudo da modelagem molecular do receptor canabinóide CB1 e suas interações com o ∆9 - THC / Molecular modeling study of CB1 cannabinoid receptor and its interaction with delta-9-THC
Marijuana (Cannabis sativa) is a widely used plant and its various applications have important benefits. The plant Cannabis sativa has been used by man for centuries for eating, medicinal practices and religious rituals. In human subjects, its effects include analgesia, alterations in perceptions, cognition, memory and psychomotor activity. The cannabinoid c
Publicado em: 2009
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17. Determinação de motivos de ligação à quitina em vicilinas de Canavalia ensiformis e Vigna unguiculata através de métodos in silico e relação com suas toxicidades para o bruquídeo Callosobruchus maculatus (Coleoptera:Bruchidae)
Chitin is an important structural component of the cellular wall of fungi and exoskeleton of many invertebrate plagues, such as insects and nematodes. In digestory systems of insects it forms a named matrix of peritrophic membrane. One of the most studied interaction models protein-carbohydrate is the model that involves chitin-binding proteins. Among the in
Publicado em: 2009
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18. Molecular modeling of arylpiperazine compounds and their interactions with the 5-HT1A receptor / Modelagem molecular de compostos arilpiperazínicos e suas interações com o receptor 5-HT1A
Selective serotonin reuptake inhibitors (SSRIs) are the most important class of antidepressants in current clinical use. However, they present the serious drawback of a delay of two to six weeks in the onset of therapeutic effect. Clinical studies have shown that when a 5-HT1A receptor antagonist is administrated along with a SSRI, an increase of extracellul
Publicado em: 2008
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19. Estudos de modelagem molecular e relação estrutura atividade da oncoproteína hnRNP K e ligantes / Molecular modeling and structure activity relationship studies of the hnRNP K oncoprotein and ligands.
The Brazilian Project Genoma Câncer (PGHC) supported by FAPESP and the Ludwig Institute for Cancer Research, intended to identify the genes involved in the most common cases of cancer in Brazil. In this project about a million of gene sequences were identified. The major contribution was made in breast, colorectal and head and neck cancers. The results obta
Publicado em: 2008
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20. Synthesis and Molecular Modeling of Carbohydrate with Potential Anti-glucosidase Activity / Síntese e modelagem molecular de carboidratos com potencial atividade anti-glucosidase
Carbohydrates of glycoconjugates display high degree of complexity and structural diversity, playing a central role in biological processes. Glucosidases are enzymes that catalyze the cleavage of glycosidic bonds in oligosaccharides or glycoconjugates, being essentials in several metabolic pathways and in the biosynthesis of glycoproteins and glycosfingolipi
Publicado em: 2008
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21. Construção de modelos de interação in silico e in vitro do inibidor do tipo Kunitz de Adenanthera pavonina L. para as enzimas cisteínicas e serínicas
Os inibidores de proteinases serínicas (IPs) estão extensamente distribuídos na natureza e inibem a atividade enzimática in vitro e in vivo. Estes IPs em sementes de leguminosas compreendem sete famílias, no entanto as famílias Bowman-Birk e do tipo Kunitz são as mais estudadas e representam um papel importante na primeira linha de defesa contra inset
Publicado em: 2008
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22. Estudo Teórico de Mecanismos para a Etapa de Eliminação da Síntese do 5-Enolpiruvilchiquimato-3-Fosfato (EPSP) catalisada pela EPSP Sintase de Oryza sativa.
In the sixth step of the shikimate pathway, catalyzed by 5-enolpyruvylshikimate-3- phosphate synthase (EPSPS), phosphoenolpyruvyl (PEP) reacts with shikimate-3-phosphate (S3P) to produce 5-enolpyruvylshikimate-3-phosphate (EPSP) and inorganic phosphate. Because the shikimate pathway is absent in animals, but is essential for plants and microrganisms, EPSPS i
Publicado em: 2008
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23. Análise da via de regulação gênica por ácido retinóico: uma abordagem por bioinformática e biologia estrutural / Analysis of retinoic acid pathway: an approach by bioinformatics and structural biology.
As vias de sinalização celular por meio de moléculas são um dos principais meios de controle funcional de um organismo. O entendimento das funções de moléculas sinalizadoras facilita a compreensão das vias metabólicas de um organismo, assim possibilitando uma melhor compreensão de vários eventos biológicos e também de várias doenças. A sinaliz
Publicado em: 2008
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24. In silico analysis identifies a C3HC4-RING finger domain of a putative E3 ubiquitin-protein ligase located at the C-terminus of a polyglutamine-containing protein
Almost identical polyglutamine-containing proteins with unknown structures have been found in human, mouse and rat genomes (GenBank AJ277365, AF525300, AY879229). We infer that an identical new gene (RING) finger domain of real interest is located in each C-terminal segment. A three-dimensional (3-D) model was generated by remote homology modeling and the fu
Brazilian Journal of Medical and Biological Research. Publicado em: 18/02/2007