Hla Dr7
Mostrando 1-12 de 216 artigos, teses e dissertações.
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1. The rs11755527 polymorphism in the BACH2 gene and type 1 diabetes mellitus: case control study in a Brazilian population
ABSTRACT Objective Type 1 diabetes mellitus (T1DM) is an autoimmune disorder caused by a complex interaction between environmental and genetic risk factors. BTB domain and CNC homolog 2 (BACH2) gene encodes a transcription factor that acts on the differentiation and formation of B and T lymphocytes. BACH2 is also involved in the suppression of apoptosis an
Arch. Endocrinol. Metab.. Publicado em: 2020-04
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2. HLA alleles in renal transplant recipients with nonmelanoma skin cancer in southeastern Brazil
Abstract: Background: Renal transplant recipients are submitted to immunosuppression to avoid graft rejection, which makes them susceptible to various conditions. Furthermore, these individuals present malignant tumors more frequently than the general population, including nonmelanoma skin cancer. The individual genetic basis that acts in the pathogenesis o
An. Bras. Dermatol.. Publicado em: 29/07/2019
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3. Immune development in HIV-exposed uninfected children born to HIV-infected women
ABSTRACT Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected (HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed contr
Rev. Inst. Med. trop. S. Paulo. Publicado em: 01/06/2017
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4. CD19+ B cell subsets in the peripheral blood and skin lesions of psoriasis patients and their correlations with disease severity
T lymphocytes are important in the pathogenesis of psoriasis, and increasing evidence indicates that B cells also play an important role. The mechanisms of action, however, remain unclear. We evaluated the ratios of CD19+ B cells in peripheral blood mononuclear cells (PBMCs) from 157 patients with psoriasis (65 patients with psoriasis vulgaris, 32 patients w
Braz J Med Biol Res. Publicado em: 15/08/2016
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5. Social and immunological differences among uninfected Brazilians exposed or unexposed to human immunodeficiency virus-infected partners
Understanding the social conditions and immunological characteristics that allow some human immunodeficiency virus (HIV)-exposed patients to remain uninfected represents an on-going challenge. In this study, the socio-demographic and sexual behaviour characteristics and immune activation profiles of uninfected individuals exposed to HIV-infected partners wer
Mem. Inst. Oswaldo Cruz. Publicado em: 09/09/2014
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6. Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis
Rupture of the spleen can be classified as spontaneous, traumatic, or pathologic. Pathologic rupture has been reported in infectious diseases such as infectious mononucleosis, and hematologic malignancies such as acute and chronic leukemias. Splenomegaly is considered the most relevant factor that predisposes to splenic rupture. A 66-year-old man with acute
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-07
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7. Doença celíaca em idade pediátrica na Ilha da Madeira e sua prevalência em familiares de primeiro grau
ContextoA doença celíaca é uma doença sistémica autoimune muito prevalente nos familiares de primeiro grau de doentes celíacos.ObjetivosO objetivo deste estudo é determinar a prevalência de doença celíaca, num grupo de familiares de primeiro grau de crianças com o diagnóstico de doença celíaca e, determinar a frequência de antígeno leucocitá
Arq. Gastroenterol.. Publicado em: 2014-06
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8. Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer
A dendritic cell (DC)-based vaccine strategy could reduce the risk of recurrence and improve the survival of breast cancer patients. However, while therapy-induced apoptosis of hepatocellular and colorectal carcinoma cells can enhance maturation and antigen presentation of DCs, whether this effect occurs in breast cancer is currently unknown. In the present
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-06
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9. Estudo da região promotora do gene da interleucina (IL-21) e do poliformismo do gene tirosina fosfatase, tipo não receptor 22 (PTPN22): associação com auto-anticorpos em pacientes portadores de diabetes mellitos tipo 1A / Allelic variant in IL21 promoter region, C1858T PTPN22 frequency and autoantibodies in Brazilian type 1A diabetes patients
As citocinas têm papel importante como mediadores através das respostas imunológicas. A Interleucina-21, importante regulador dos linfócitos T e B, é produzida por linfócitos CD4 ativados, e está implicada na patogênese do diabetes autoimune em modelo animal, o NOD. A região promotora da IL-21, que contempla sítios de controle da expressão gênica
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2011
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10. Investigação de um possível viés imunossupressor em células dendríticas derivadas de indivíduos portadores de cancêr. / Investigation of a possible immunosuppressive bias in dendritic cells derived from cancer patients.
As células dendríticas (DCs) são as mais eficazes células apresentadoras de antígenos. Mesmo com a possibilidade da geração de DCs in vitro, que permitiu a criação de protocolos de vacinação antitumoral, mecanismos de tolerância periférica, mediados por células T reguladoras, impedem uma resposta imune antitumoral eficaz. O presente estudo viso
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2011
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11. Avaliação das células de Langerhans na língua de pacientes autopsiados com AIDS em estágio avançado / Expression of Langerhans cells in the tongue of autopsied patients with advanced AIDS
The tongues of AIDS patients can be affected by opportunistic infections and neoplasms. Objectives: to quantify and compare the expression of Langerhans cells (LC) in lesional and non lesional areas in the tongue from patients with and without AIDS (control group), using autopsy material. Methods: we analysed the expression of CD1a, HLA-DR and CD83 using imm
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2010
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12. Rastreamento sorológico e tipagem genética em pacientes com doença celíaca e em seus parentes de primeiro grau
CONTEXTO: A susceptibilidade para a doença celíaca está principalmente associada à presença dos alelos HLA DQA1*0501 e DQB1*0201 (que conjuntamente codificam o heterodímero DQ2), os quais são praticamente encontrados em todos os pacientes celíacos. O heterodímero DQ8 (codificado pelos alelos DQA1*03 e DQB1*0302) associado ao haplotipo DRB1*04 (DR4)
Arquivos de Gastroenterologia. Publicado em: 2010-09