Hemoglobin Digestion
Mostrando 1-12 de 40 artigos, teses e dissertações.
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1. Duffy Genotype and Clinical Manifestations Severity in Sickle Cell Anemia / Genótipo Duffy e Gravidade das Manifestações Clínicas na Anemia Falciforme
INTRODUCTION: Sickle cell anemia (SCA) presents with large clinical variability and previous studies suggest that genetic polymorphisms may act as complications predictors. The Duffy antigen appears to play an important role in the removal of inflammatory chemokines from the circulation, suggesting that Duffy-Negative individuals have lower clearance of cyto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/03/2011
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2. Atividades antinociceptiva e antiinflamatÃria dos polissacarÃdeos sulfatados da alga marinha vermelha Gracilaria cornea J. Agardh / Antinociceptive and anti-inflammatory activities of sulfated polusaccharides from the red marine alga Gracilaria cornea J. Agardh (1852) in animals
Marine algae are natural sources of sulfated polysaccharides possessing several biological activities (anticoagulant, antithrombotic, antinociceptive, anti-inflammatory etc.) and that exhibit minimal toxicity and are considered of great interest to the pharmaceutical and food industries. This study aimed to evaluate the effects of sulfated polysaccharides to
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/02/2011
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3. Isolamento e caracterização de peptídeos antimicrobianos derivados da digestão da hemoglobina em Rhipicephalus (Boophilus microplus) / Isolation and characterization of antimicrobial peptides produced during hemoglobin digestion on Rhipicephalus (Boophilus) microplus.
The hemoglobin posses a great potential as an antimicrobial, being denominated hemocidins the antimicrobial peptides (AMPs) derived from heme containing proteins. The cattle tick Rhipicephalus (Boophilus) microplus is capable of processing large amounts of blood to its own metabolism. In this work we purified the hemocidins that are produced in the tick gut.
Publicado em: 2010
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4. Expression of schistosomal cathepsin l1 in Escherichia coli and evaluation of its protective capacity in an animal challenge
Schistosomes utilize proteinases to accomplish several activities such as tissue penetration, tissue digestion and evasion of host immune responses. Cathepsin L is a cysteine proteinase of the papain superfamily detected in their gut lumen which indicates that this enzyme contributes to the proteolysis of ingested hemoglobin. Due to the roles played in the s
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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5. The use of internal dose biomarkers for assessment of lead exposure and its correlations with anemia and genetic polymorphisms from children living in uncontaminated area / Utilização de biomarcadores de dose interna para avaliação da exposição ao chumbo e suas correlações com anemia e polimorfismos geneticos em crianças residentes em uma região supostamente não contaminada
With increasing evidence of adverse health effects of lower levels of lead (below 10 $g/dL in whole blood), studies on novel internal dose biomarkers are needed. In Brazil, some studies showed high amounts of lead in the superficial enamel of deciduous enamel. The aim of this study was 1) to determine and to correlate the lead concentration in children livin
Publicado em: 2009
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6. Enzimas de organismos aquÃticos e suas aplicaÃÃes fisiolÃgicas
In the last years, there has been a general increase in human demand for fishery products, followed by a significant increase in the world production of aquatic organisms. The growth of fishery industry generates, as consequence, large amounts of wastes and by-products rich in biomolecules, which are discharged into envioronment. Fishery wastes can be used i
Publicado em: 2009
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7. Soybean oil in atlhetic horses diets. / Óleo de soja em dietas para eqüinos atletas.
This work aimed to evaluate intake in athletic horses fed diets with soybean oil inclusion and the effects of apparent digestibility of nutrients, digestive kinetics, faeces characters and physiologic, hematological and biochemical parameters and. In first essay, fifteen horses were used in a completely randomized design with three diets and five repetitions
Publicado em: 2008
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8. Aspartic protease activities of schistosomes cleave mammalian hemoglobins in a host-specific manner
We examined the efficiency of digestion of hemoglobin from four mammalian species, human, cow, sheep, and horse by acidic extracts of mixed sex adults of Schistosoma japonicum and S. mansoni. Activity ascribable to aspartic protease(s) from S. japonicum and S. mansoni cleaved human hemoglobin. In addition, aspartic protease activities from S. japonicum cleav
Memórias do Instituto Oswaldo Cruz. Publicado em: 2007-02
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9. The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease
Sickle cell disease (SCD) is one of the most common inherited diseases in the world and the patients present notorious clinical heterogeneity. It is known that patients with SCD present activation of the blood coagulation and fibrinolytic systems, especially during vaso-occlusive crises, but also during the steady state of the disease. We determined if the p
Brazilian Journal of Medical and Biological Research. Publicado em: 09/08/2006
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10. A dual role for the Ca2+-requiring proteinase in the degradation of hemoglobin by erythrocyte membrane proteinases.
Binding of hemoglobin chains to erythrocyte membranes is an obligatory step in the conversion of hemoglobin to acid-soluble products by erythrocyte proteinases. This binding requires limited proteolysis of the hemoglobin chains and also modification of the inner surface of the erythrocyte membrane, both of which result from the action of a soluble Ca2+-requi
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11. Hemoglobinase Activity of the Lysine Gingipain Protease (Kgp) of Porphyromonas gingivalis W83
Porphyromonas gingivalis, an important periodontal disease pathogen, forms black-pigmented colonies on blood agar. Pigmentation is believed to result from accumulation of iron protoporphyrin IX (FePPIX) derived from erythrocytic hemoglobin. The Lys-X (Lys-gingipain) and Arg-X (Arg-gingipain) cysteine proteases of P. gingivalis bind and degrade erythrocytes.
American Society for Microbiology.
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12. Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders
Human cellular DNA fragments from cells of normal subjects and patients with thalassemia obtained by restriction enzyme digestion were analyzed for their globin gene content. The fragments were separated on agarose gels, transferred to nitrocellulose filters, hybridized to globin [32P]cDNA, and radioautographed. One to ten picograms of globin gene sequences