Hedgehog Signalling Pathway
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Análise de genes diferencialmente expressos nas vias de sinalização (Hedgehog e Wnt) em carcinomas basocelulares humanos
Hedgehog (HH) and Wingless-Int (Wnt) signaling pathway are related to the process of cellular proliferation, differentiation, angiogenesis, matrix remodeling and homeostasis of stem cells. Over the years, several mutations in HH signaling pathway have been identified, including the loss of function mutations in ptch1 and the gain of function mutations in smo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/04/2012
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2. Estudo imunoistoquimico da incorporação de enxerto alogeno com proteina morfogenetica do osso-2 na mandibula de rato
Large bone defects can be managed by autogenous graft; however limitations in this source have induced research for new materials to replace autogenous graft. The incorporation of autoclaved alogenous bone graft associated to recombinant human bone morphogenetic protein 2 (rhBMP-2) was the objective of this study. The study animals were 75 Wistar rats distri
Publicado em: 2004
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3. From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified.
BioMed Central.
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4. Hedgehog signalling in breast cancer
Breast cancer is the most common cause of cancer death among women worldwide. In order to improve the treatment of this disease, a more complete understanding of its biological basis is necessary. Since the Hedgehog (Hh) pathway was recently found to be required for growth and propagation of a number of different cancers, we discuss here the possible involve
Oxford University Press.
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5. Overgrowth of a mouse model of Simpson– Golabi–Behmel syndrome is partly mediated by Indian Hedgehog
Loss-of-function mutations of Glypican 3 (Gpc3) cause the Simpson–Golabi–Behmel overgrowth syndrome (SGBS), and developmental overgrowth is observed in Gpc3-null mice, a mouse model for SGBS. We recently reported that GPC3 inhibits Hedgehog (Hh) signalling by inducing its endocytosis and degradation. Here, we show that the developmental overgrowth observ
Nature Publishing Group.