Harmine
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. The pharmacological interaction of compounds in ayahuasca: a systematic review
Ayahuasca is a South American psychoactive plant brew used as traditional medicine in spiritual and in cultural rituals. This is a review of the current understanding about the pharmacological mechanisms that may be interacting in ayahuasca. Searches were performed using PubMed, PsycINFO, and Web of Science databases and 16 papers were selected. As hypothesi
Braz. J. Psychiatry. Publicado em: 2020-12
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2. Use of Coconut Charcoal and Menthone-Thiosemicarbazone Polymer as Solid Phase Materials for the Determination of N,N-Dimethyltryptamine, Harmine, Harmaline, Harmalol, and Tetrahydroharmine in Ayahuasca Beverage by Liquid Chromatography-Tandem Mass Spectrometry
An extraction method based on solid-phase extraction was developed to determine the major alkaloid components, N,N-dimethyltryptamine, harmine, harmaline, harmalol, and tetrahydroharmine, in ayahuasca using ultra-performance liquid chromatography-tandem mass spectrometry. Coconut charcoal and menthone-thiosemicarbazone polymer were tested as new adsorbent ma
J. Braz. Chem. Soc.. Publicado em: 2019-01
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3. Targeted-Analysis of β-Carboline Alkaloids in Passionfruit (“Maracujá”) by SBSE(PDMS)-LC/Flu and UHPLC-MS
Samples of pulp and seeds of sour (P. edulis) and sweet (P. alata) passionfruit were subjected to targeted analysis to identify β-carboline alkaloids, using combined UHPLC-MS (ultrahigh performance liquid chromatography-mass spectrometry) and SBSE(PDMS) (stir bar sorption extraction using polydimethylsiloxane as stationary phase) for sample preconcentration
J. Braz. Chem. Soc.. Publicado em: 2018-04
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4. Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure
Abstract Ayahuasca is a psychoactive beverage used ancestrally by indigenous Amazonian tribes and, more recently, by Christian religions in Brazil and other countries. This study aimed to investigate the reproductive effects of this beverage in male Wistar rats after chronic exposure. The rats were treated by gavage every other day for 70 days at 0 (control)
Rev. bras. farmacogn.. Publicado em: 2017-06
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5. Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies
Objective: To conduct a systematic literature review of animal and human studies reporting anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids (dimethyltryptamine, harmine, tetrahydroharmine, and harmaline). Methods: Papers published until 3 April 2015 were retrieved from the PubMed, LILACS and SciELO databases following a c
Rev. Bras. Psiquiatr.. Publicado em: 2016-03
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6. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-la
Rev. Bras. Psiquiatr.. Publicado em: 2015-03
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7. Evaluation of the neurotoxic effects of ayahuasca tea / Avaliação dos efeitos neurotóxicos do chá ayahuasca
Ayahuasca tea is a psychotropic beverage that has caused controversy due to the fact of being used indiscriminately by some group of people and the ease of purchase in the worldweb. The tea is derived by boiling the bark of the liana Banisteriopsis Caapi (B. Caapi) together with the leaves of Psychotria Viridis (P.Viridis). B. Caapi contains alkaloids as har
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/06/2012
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8. Efeitos comportamentais e neuroquímicos da harmina em modelos animais de depressão
Harmina é uma β-carbolina que atua sobre o SNC, inibindo a enzima monoaminooxidase tipo A-MAO. Esse alcalóide liga-se com relativa afinidade a receptores cerebrais de serotonina como a 5-hidroxitriptamina, subtipos 5-HT2C e 5-HT2A e receptores imidazólicos (I2). O objetivo deste estudo foi investigar os efeitos comportamentais e fisiológicos da administ
Publicado em: 2010
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9. DESENVOLVIMENTO DE MÉTODOS ANALÍTICOS ESPECTROLUMINESCENTES E ELETROFORÉTICOS PARA A DETERMINAÇÃO DE ALCALOIDES (BETA-CARBOLINAS, CAMPTOTECINA E DERIVADOS) DE INTERESSE FARMACOLÓGICO / DEVELOPMENT OF ANALYTICAL METHODS BASED ON LUMINESCENCE AND ELECTROPHORESIS FOR THE DETERMINATION OF ALKALOIDS (BETA-CARBOLINES, CAMPTOTHECIN AND DERIVATIVES) OF PHARMACOLOGICAL INTEREST
Analytical methods were developed for the selective determination of alkaloids of pharmacological interest. Aiming the selective determination of camptothecin (CPT) in irinotecan (CPT-11) or topotecan (TPT) based pharmaceutical formulations, two spectrofluorimetric methods and one electrophoretic method with absorciometic detection were proposed. The spectro
Publicado em: 2009
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10. LC AND UV DETERMINATION OF ALCALOID AND FLAVONOID Passiflora alata CURTIS, Passifloraceae EXTRACTS / "DETERMINAÇÃO DE ALCALÓIDES E FLAVONÓIDES ATRAVÉS DE CLAE E UV DE EXTRATOS DE Passiflora alata CURTIS, Passifloraceae - MARACUJÁ-DOCE".
Leaves of Passiflora alata Curtis (official species in the Brazilian Pharmacopoeia) are employed for anxiety, as antispasmodic and sedative. The development of new analytical methodologies for the analysis of flavonoids and alkaloids in Passiflora species are needed in order to improve the quality assurance of the plant and derived extract and phytomedicines
Publicado em: 2006
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11. FOSFORIMETRIA NA TEMPERATURA AMBIENTE E EM SUBSTRATO SÓLIDO (FTASS) PARA A DETERMINAÇÃO DE DOIS DERIVADOS DA BETA-CARBOLINA (HARMANE E HARMINE) / SOLID SURFACE ROOM-TEMPERATURE PHOSPHORIMETRY (SSRTP) FOR THE DETERMINATION OF TWO BETA-CARBOLINES DERIVATIVES (HARMANE E HARMINE)
Neste trabalho foi avaliado o uso da Fosforimetria na Temperatura Ambiente em Substrato Sólido (FTASS) como técnica analítica aplicável na determinação de dois derivados da ¿-carbolina (harmane e harmine). Como suporte sólido foi utilizado o papel de filtro de baixo sinal de fundo. As características fosforescentes dos analitos foram estudadas em fu
Publicado em: 2005
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12. Role of cloned carotenoid genes expressed in Escherichia coli in protecting against inactivation by near-UV light and specific phototoxic molecules.
Genes controlling carotenoid synthesis were cloned from Erwinia herbicola and expressed in an Escherichia coli strain. Carotenoids protect against high fluences of near-UV (NUV; 320 to 400 nm) but not against far-UV (200-300 nm). Protection of E. coli cells was not observed following treatment with either psoralen or 8-methoxypsoralen plus NUV. However, sign