Glycogen Synthase Kinase 3
Mostrando 13-24 de 182 artigos, teses e dissertações.
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13. A atividade da enzima Glicogênio Sintase Quinase 3 Beta (GSK-3B) em pacientes idosos com depressão maior: associação com parâmetros clínicos, psicopatológicos e cognitivos / Glycogen Synthase Kinase 3 Beta (GSK-3B) activity in elderly patients with major depressive disorder: association with clinical, psychopathological and cognitive aspects
Apesar da elevada prevalência dos transtornos depressivos em idosos, os mecanismos fisiopatológicos subjacentes a estes quadros são pouco conhecidos. Atualmente, o principal foco dos estudos sobre a fisiopatologia da depressão geriátrica são as alterações cerebrovasculares associadas a estes quadros. Outros mecanismos fisiopatológicos têm sido estu
Publicado em: 2011
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14. Glicogênio sintase quinase3B e proteína precursora do amilóide em plaquetas de indivíduos com comprometimento cognitivo leve e doença de Alzheimer / Glycogen synthase kinase 3B and amyloid precursor protein in adults platelets with cognitive impairment and Alzheimers disease
Alzheimers disease (AD) is a neurodegenerative disease characterized by progressive decline of memory and other cognitive functions, affecting mainly elderly. The abnormal metabolism of amyloid precursor protein (APP) and protein TAU hyperphosphorylation are cellular hallmarks of this disease. Glycogen synthase kinase 3B (GSK3B) is an enzyme highly expressed
Publicado em: 2010
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15. Germ band retraction as a landmark in glucose metabolism during Aedes aegypti embryogenesis
Background: The mosquito A. aegypti is vector of dengue and other viruses. New methods of vector control are needed and can be achieved by a better understanding of the life cycle of this insect. Embryogenesis is a part of A. aegypty life cycle that is poorly understood. In insects in general and in mosquitoes in particular energetic metabolism is well studi
Publicado em: 2010
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16. Influence of stress on gene expression and broiler meat quality / Influência do estresse pré-abate na expressão gênica e qualidade da carne de frango (Gallus gallus)
Brazilian broiler production yields a considerable amount of income for the nation. Brazil is currently the world's third broiler producer and the first chicken meat exporter, contributing with 41% of the whole world market. To reach new market frontiers it is inevitable the improvement of meat quality. Among the reasons that influences final products qu
Publicado em: 2007
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17. Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.
In these studies we expressed and characterized wild-type (WT) GSK-3 (glycogen synthase kinase-3) and its mutants, and examined their physiological effect on glycogen synthase activity. The GSK-3 mutants included mutation at serine-9 either to alanine (S9A) or glutamic acid (S9E) and an inactive mutant, K85,86MA. Expression of WT and the various mutants in a
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18. Phosphorylation and inactivation of glycogen synthase by phosphorylase kinase.
Skeletal muscle glycogen a4-synthase (EC 2.4.1.11) has been purified free of all synthase kinase and phosphatase activities by chromatography on a Glc-N-6-P-Sepharose affinity column and then on a phosphocellulose column. This preparation of glycogen synthase was tested as a substrate for purified skeletal muscle phosphorylase kinase (ATP:phosphorylase-b pho
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19. Isolation of a glycogen synthase I kinase that is independent of adenosine 3':5'-monophosphate.
Three protein kinases (ATP:protein phosphotransferase, EC 2.7.1.37) were detected when the soluble fraction of rabbit kidney medulla was chromatographed on DEAE-cellulose with a linear NaC1 gradient. The first two kinases eluted (Peak 1 and Peak II) were cyclic-AMP-dependent, wheras Peak III was cyclic-AMP-independent. A procedure was developed to separate t
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20. Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription
Axin antagonizes the developmental effects of Wnt in vertebrates. We show here that Axin simultaneously binds two components of the Wnt pathway, β-catenin and its negative regulator glycogen synthase kinase-3β. In mammalian cells, Axin inhibits Wnt-1 stimulation of β-catenin/lymphoid enhancer factor 1-dependent transcription. Axin also blocks β-catenin-m
The National Academy of Sciences.
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21. Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle.
To investigate the role of glycogen synthase in controlling glycogen accumulation, we generated three lines of transgenic mice in which the enzyme was overexpressed in skeletal muscle by using promoter-enhancer elements derived from the mouse muscle creatine kinase gene. In all three lines, expression was highest in muscles composed primarily of fast-twitch
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22. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
Glycogen synthase kinase 3 (GSK-3) is implicated in multiple biological processes including metabolism, gene expression, cell fate determination, proliferation, and survival. GSK-3 activity is inhibited through phosphorylation of serine 21 in GSK-3α and serine 9 in GSK-3β. These serine residues of GSK-3 have been previously identified as targets of pr
The National Academy of Sciences.
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23. Molecular cloning and expression of glycogen synthase kinase-3/factor A.
Glycogen synthase kinase-3 (GSK-3) is a protein-serine kinase implicated in the hormonal control of several regulatory proteins including glycogen synthase and the transcription factor c-jun. Two classes of rat brain cDNA for this enzyme have been isolated termed GSK-3 alpha and GSK-3 beta. The alpha-type encodes a 51 kd polypeptide, the sequence of which in
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24. Altered Extracellular Signal-Regulated Kinase Signaling and Glycogen Metabolism in Skeletal Muscle from p90 Ribosomal S6 Kinase 2 Knockout Mice
The p90 ribosomal S6 kinase (RSK), a cytosolic substrate for the extracellular signal-regulated kinase (ERK), is involved in transcriptional regulation, and one isoform (RSK2) has been implicated in the activation of glycogen synthase by insulin. To determine RSK2 function in vivo, mice lacking a functional rsk2 gene were generated and studied in response to
American Society for Microbiology.