Glutathione S Transferases
Mostrando 1-12 de 87 artigos, teses e dissertações.
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1. Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population
Abstract Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 heal
Genet. Mol. Biol.. Publicado em: 2018-03
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2. A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients
Abstract: Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results. Objective: The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Eg
An. Bras. Dermatol.. Publicado em: 2018-02
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3. Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet
Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Yerba mate beverages are an important source of antioxidants, but there is scarce knowledge about their effect
Braz J Med Biol Res. Publicado em: 30/11/2017
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4. The Role of the Conformational Dynamics of Glutathione S-Transferase Epsilon Class on Insecticide Resistance in Anopheles gambiae
Glutathione S-transferases (GSTs) are enzymes capable of metabolizing cytotoxic compounds. The enzyme AgGSTE2, member of epsilon class GSTs (GSTE), is the most important GST conferring resistance to dichloro-diphenyl-trichloroethane (DDT) in Anopheles gambiae. We have investigated the conformational dynamics of three GSTE variants (GSTE2, GSTE2-I114T/F120L,
J. Braz. Chem. Soc.. Publicado em: 2016-09
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5. Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation
The aim of this study was to develop a theoretical model using Anopheles gambiae GSTE2 structure as template for Aedes aegypti GSTE2 by homology modeling Docking simulations were performed for both the enzymes against usnic acid in neutral and anionic forms. Ramachandran plot revealed that 93.9% of the GSTE2 model residues were located on most favored region
Braz. arch. biol. technol.. Publicado em: 2014-10
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6. Os Genes Codificadores de Glutationa S-transferases na Abelha Apis mellifera: Expressão, Regulação e Função Durante e Após a Metamorfose. / The genes Encoding Glutathione S-transferases in the Honeybee (Apis mellifera): expression, regulation and function during and After Metamorphosis.
Em insetos, as enzimas glutationa S-transferases (GSTs) são conhecidas pela capacidade de degradar inseticidas, pesticidas e outros compostos químicos, naturais ou não naturais, estranhos ao organismo, podendo também promover o transporte intracelular de hormônios, metabólitos, e atuar na proteção celular contra o estresse oxidativo. Além disto, a f
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/10/2011
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7. Estudo dos polimorfismos dos genes de enzimas de metabolização/detoxificação na susceptibilidade ao lúpus eritematoso sistêmico
O Lúpus Eritematoso Sistêmico (LES) é uma doença inflamatória crônica autoimune que apresenta uma ampla variedade de manifestações clínicas e anormalidades imunológicas, afetando principalmente mulheres. É caracterizado pela perturbação da homeostase imunológica, que envolve a indução e produção de autoanticorpos, bem como pela formação e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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8. Melatonina, isoenzimas de glutationa S-transferases e estresse oxidante em pacu Piaractus mesopotamicus (Holmberg, 1887) / Melatonin, Glutathione S-transferases isoenzymes, and oxidative stress in pacu, Piaractus mesopotamicus (Holmberg, 1887).
Oxygen is vital for vertebrates. However, changes in the levels of dissolved oxygen in water might cause oxidative stress in fishes because the shortage of oxygen followed by reoxygenation originates reactive oxygen species (ROS) inside cells. Higher intracellular levels of ROS favor alterations of proteins, phospholipids and nucleic acid molecules, which re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/03/2010
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9. Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
Antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX1) reduce the oxidation rates in the organism. Gluthatione S-transferases (GSTs) play a vital role in phase 2 of biotransformation of many substances. Variation in the expression of these enzymes suggests individual differences for the degree of antioxidant protect
Genetics and Molecular Biology. Publicado em: 26/11/2010
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10. Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)
In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast. As appeared in several published studies, ethnic differences in these frequencies have been found to play an important role in the metabolism of a relevant n
Genetics and Molecular Biology. Publicado em: 02/07/2010
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11. Proteção cruzada contra a infestação de Rhipicephalus (Boophilus) microplus em bovinos vacinados com a glutationa-s-transferase recombinante de Haemaphysalis longicornis
Os carrapatos Rhipicephalus (Boophilus) microplus e Haemaphysalis longicornis são ectoparasitas hematófagos que infestam bovinos. O uso de vacinas anticarrapato tem mostrado ser uma estratégia alternativa promissora para o controle desses parasitos. As glutationa-S-transferases (GSTs) pertencem a uma família de enzimas multifuncionais presentes em organi
Publicado em: 2010
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12. Proximal tubular dysfunction as an indicator of chronic graft dysfunction
New strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-03