Glutathione S Transferase
Mostrando 25-36 de 1073 artigos, teses e dissertações.
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25. Characterization of an alcoholic hepatic steatosis model induced by ethanol and high-fat diet in rats
Alcoholic liver disease is characterized by a wide spectrum of liver damage, which increases when ethanol is associated with high-fat diets (HFD). This work aimed to establish a model of alcoholic hepatic steatosis (AHS) by using a combination of 10% ethanol and sunflower seeds as the source of HFD. Male rats received water or 10% ethanol and regular chow di
Braz. arch. biol. technol.. Publicado em: 06/03/2015
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26. Combined administration of silymarin and vitamin C stalls acetaminophen-mediated hepatic oxidative insults in Wistar rats
Oxidative insult by free radicals has been implicated in drug-induced hepatic damage and this has resulted in frequent episodes of liver disorders. Therapeutic efficacy of antioxidants may provide a possible solution to this menace. This study was carried out to investigate the effect of combined administration of silymarin and vitamin C in rescuing acetamin
Rev. bras. farmacogn.. Publicado em: 2015-02
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27. Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats
This study was designed to investigate the protective effects of sodium selenite and/or vitamin E against mercuric chloride-induced cardiotoxicity. Male Wistar rats (n=48, 310±10 g) were administered mercuric chloride (1.0 mg/kg bw), sodium selenite (0.25 mg/kg bw), vitamin E (100 mg/kg bw), sodium selenite plus mercuric chloride, vitamin E plus mercuric ch
Braz. arch. biol. technol.. Publicado em: 13/01/2015
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28. Hepatotoxicity and oxidative stress induced byNaja haje crude venom
Background Snake venoms are synthesized and stored in venom glands. Most venoms are complex mixtures of several proteins, peptides, enzymes, toxins and non-protein components. In the present study, we investigated the oxidative stress and apoptosis in rat liver cells provoked by Naja haje crude injection (LD50) after four hours.Methods Wistar rats were rando
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/10/2014
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29. Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite
Among heavy met als, lead is one of the common pollutants found in the environment and biological system. In the present study, streptozotocin-induced diabetic and normal non-diabetic male Wistar rats were given sodium selenite (1.0 mg/kg bw), lead nitrate (22.5 mg/kg bw) and sodium selenite plus lead nitrate (1.0 mg/kg+22.5 mg/kg bw, respectively) through g
Braz. arch. biol. technol.. Publicado em: 01/08/2014
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30. Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
Objective To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro and compare the distribution of allele and genotype frequencies of the polymorphisms analyzed in the present study population with other regions in the country and different ethnic groups.
Int. braz j urol.. Publicado em: 2014-08
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31. Molecular characteristics, recombinant expression and activity detection of OsGSTL1 from rice
The mRNA of OsGSTL1 was detected in the roots and leaves of rice plants at seedling and tillering stages, and their roots, leaves and panicles at the heading stage. The full-length open reading frame of OsGSTL1 cDNA was 732 bp and encoded a putative polypeptide of 243 amino acids with a calculated molecular mass of 27.30 kDa and a theoretical pI of 5.50. The
Braz. arch. biol. technol.. Publicado em: 2014-02
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32. Toxicological and biochemical analysis of the susceptibility of sylvatic Triatoma infestans from the Andean Valley of Bolivia to organophosphate insecticide
To increase our knowledge of the natural susceptibility of Triatoma infestans to an organophosphate insecticide, we performed toxicological and biochemical studies on three sylvatic populations from Bolivia and two populations from domestic dwellings from Bolivia and Argentina. Fifty-per-cent lethal doses (LD50) were determined based on the topical applicati
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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33. Induction of protective T-helper 1 immune responses against Echinococcus granulosus in mice by a multi-T-cell epitope antigen based on five proteins
In this study, we designed an experiment to predict a potential immunodominant T-cell epitope and evaluate the protectivity of this antigen in immunised mice. The T-cell epitopes of the candidate proteins (EgGST, EgA31, Eg95, EgTrp and P14-3-3) were detected using available web-based databases. The synthesised DNA was subcloned into the pET41a+ vector and ex
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-06
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34. Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male sprague-dawley rats
OBJECTIVE: Fenitrothion residue is found primarily in soil, water and food products and can lead to a variety of toxic effects on the immune, hepatobiliary and hematological systems. However, the effects of fenitrothion on the male reproductive system remain unclear. This study aimed to evaluate the effects of fenitrothion on the sperm and testes of male Spr
Clinics. Publicado em: 2013-01
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35. Modificações morfológicas e metabólicas em gramínea e leguminosa forrageiras tropicais relativas ao suprimento de enxofre / Metabolic and morphological changes in grass and legume tropical forages related to sulfur supply
O enxofre é um dos elementos essenciais para as plantas e as exigências nutricionais nesse nutriente variam com a espécie e a taxa de crescimento das plantas. Com o objetivo geral de avaliar o efeito da nutrição em enxofre no crescimento e no metabolismo do capimtanzânia (Panicum maximum cv. Tanzânia) e do estilosante (Stylosanthes guianensis cv. Mine
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/12/2012
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36. Efeito da resistência de Spodoptera frugiperda (J.E.Smith, 1797) (Lepidoptera: Noctuidae) a lambda-cyhalothrin na interação com o milho geneticamente modificado (MON810) e na resposta imunológica ao parasitismo por Campoletis af / Effect of resistance of Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae) to lambda-cyhalothrin on the interaction with genetically modified maize (MON810) and the immune response to parasitization by Campoletis aff. flavicincta (Hymenoptera: Ichneumonidae)
Fitness costs of insect resistance to insecticides can be exploited by integrating other pest control strategies in Integrated Pest Management (IPM) programs. The objective of this research was to evaluate the existence of fitness costs associated with the resistance of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) to the pyrethroid insecticid
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/05/2012