Glucocorticoid Receptors
Mostrando 13-24 de 245 artigos, teses e dissertações.
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13. Regulação da expressão do promotor do gene do receptor de glicocorticoide em clones de celulas transfectadas com o photo-oncogene c-jun
Glucocorticoid receptors ( GR ) mediate the cellular response to glucocorticoid hormones which are known for their anti-inflammatory and anti-tumoral actions. The mechanisms involved on the regulation of GR gene expression are extremely important for the cellular response to the hormone and remain unknow. Using transient transfections, we have previously rep
Publicado em: 1996
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14. Different regions of the estrogen receptor are required for synergistic action with the glucocorticoid and progesterone receptors.
Estrogen and progesterone or estrogen and glucocorticoid receptors functionally cooperate in gene activation if their cognate binding sites are close to one another. These interactions have been described as synergism of action of the steroid receptors. The mechanism by which synergism is achieved is not clear, although protein-protein interaction of the rec
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15. Recessive lethal deletion on mouse chromosome 7 affects glucocorticoid receptor binding activities.
The hormone binding activity of glucocorticoid receptors is decreased by approximately equal to 75% in the livers of mice homozygous for c14CoS, one of several overlapping radiation-induced deletions on chromosome 7. These deletions have been shown previously to map at and around the albino (c) locus and to act as recessive lethals. They are associated with
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16. Glucocorticoid Action on Hybrid Clones Derived from Cultured Myeloma and Lymphoma Cell Lines
Cells of a cloned myeloma line from a Balb/c mouse contain specific cytoplasmic glucocorticoid receptors and are killed by dexamethasone. Cells of a lymphoma line (from mouse strain C57BL) also contain specific glucocorticoid receptors but are resistant to the steroid. Cells of two hybrid clones with widely differing chromosome numbers, derived by fusion bet
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17. Rat Anterior Pituitary: DISTINCTION OF AN ∼8S, CORTICOSTERONE-PREFERRING SPECIES FROM DEXAMETHASONE-BINDING GLUCOCORTICOID RECEPTORS
Studies on the feedback inhibition of ACTH release by steroid hormones and on the binding of tritiated steroids by the pituitary have prompted the hypothesis that receptors in addition to or other than classical glucocorticoid receptors may mediate steroid hormone effects in this tissue. Accordingly, we have asked whether more than one glucocorticoid-binding
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18. Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors.
The glucocorticoid receptor accumulates in nuclei only in the presence of bound hormone, whereas the estrogen receptor has been reported to be constitutively nuclear. To investigate this distinction, we compared the nuclear localization domains of the two receptors and the capacity of their respective hormone-binding regions to regulate nuclear localization
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19. Correlations between the activities of DNA polymerase alpha and the glucocorticoid receptor.
Specific inhibitors and anti-DNA polymerase alpha IgG have been utilized to probe for similarities between cytoplasmic rat hepatic glucocorticoid receptors and DNA polymerase alpha [DNA nucleotidyltransferase (DNA-directed), EC 2.7.7.7]. Rifamycin AF/013, an inhibitor of RNA and DNA polymerase activities, significantly inhibited the binding of activated [6,7
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20. Dexamethasone 21-mesylate: an affinity label of glucocorticoid receptors from rat hepatoma tissue culture cells.
We recently described the biological properties of an alpha-keto mesylate derivative of cortisol, cortisol-Mes. Cortisol-Mes exhibited long-term antiglucocorticoid activity, but there was no firm evidence that this activity was irreversible or receptor-mediated. Here we report that dexamethasone mesylate (Dex-Mes), which is the alpha-keto mesylate derivative
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21. The glucocorticoid receptor resource.
The glucocorticoid receptor resource focuses on the structure-function relationships of the glucocorticoid receptor. As well as links to sequence and bibliographic databases via the World Wide Web, the database contains sequence comparisons of receptors from different species and source information for glucocorticoid receptor clones, probes, cell lines and a
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22. Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.
The hippocampus is the principal target site in the brain for adrenocortical steroids, as it has the highest concentration of receptor sites for glucocorticoids. The aged rat has a specific deficit in hippocampal glucocorticoid receptors, owing in large part to a loss of corticoid-sensitive neurons. This deficit may be the cause for the failure of aged rats
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23. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors.
After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation. A search for possible coactivators for steroid hormone receptors resulted in identification of glucocorticoid receptor interacting protein 1 (GRIP1). The complete coding sequence for GRIP1, isolated
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24. Glucocorticoid Receptor Homodimers and Glucocorticoid-Mineralocorticoid Receptor Heterodimers Form in the Cytoplasm through Alternative Dimerization Interfaces
Steroid hormone receptors act to regulate specific gene transcription primarily as steroid-specific dimers bound to palindromic DNA response elements. DNA-dependent dimerization contacts mediated between the receptor DNA binding domains stabilize DNA binding. Additionally, some steroid receptors dimerize prior to their arrival on DNA through interactions med
American Society for Microbiology.