Glucagon Like Peptide 1
Mostrando 13-24 de 88 artigos, teses e dissertações.
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13. Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
BACKGROUND: Various digestive tract procedures effectively improve metabolic syndrome, especially the control of type 2 diabetes mellitus. Very good metabolic results have been shown with vertical gastrectomy and entero-omentectomy; however, the metabolic effects of an isolated entero-omentectomy have not been previously studied. METHODS: Nine patients with
Clinics. Publicado em: 2011
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14. Efeito de frações peptídicas do veneno da serpente Bothrops jararaca (Serpentes, Viperidae: Crotalinae) sobre a atividade enzimática dipeptidil-peptidase IV (DPP-IV) e sobre o receptor (GLP-1R) do peptídeo glucagon-símile tipo 1 (GLP-1). / Effect of peptide fractions from Bothrops jararaca (Serpentes, Viperidae: Crotalinae) venom on dipeptidyl-peptidase IV (DPP-IV) enzyme activity and glucagon-like peptide 1 receptor (GLP-1R).
Novos agentes terapêuticos que preservem as células β do pâncreas e o controle do peso são importantes para o diabetes melittus tipo 2 (DM-2), constituindo uma importante área de investimento farmacêutico. Com o objetivo de contribuir com a toxinologia comparada de venenos de répteis e com a eventual descoberta de novos agentes
Publicado em: 2010
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15. Regulação endócrina de curto prazo de hormônios relacionados à fome em mulheres obesas que apresentam episódios de compulsão alimentar / Short-term endocrine regulation of hunger related hormones in obese women with binge eating episodes
Binge eating is associated to several diseases, including obesity. In order to study the hormonal control of hunger and satiety that is commonly involved in binge-eating process; we evaluated the serum concentration of these hormones in adult women. The experimental study was composed of 3 groups, n= 23: Lean (GE, n = 8), Obese without binge (GO, n = 7) and
Publicado em: 2010
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16. Aspectos clínicos e metabólicos de pacientes obesos do sistema único de saúde, submetidos à operação de capella no Hospital das Clínicas da UFMG
Introdução: A prevalência da obesidade classe III ou mórbida aumentou nos últimos decênios e as operações bariátricas têm sido indicadas como importante modalidade de tratamento para obesos graves, com objetivo de promover a perda e manutenção do peso corporal por médio e longo prazo. Comorbidades como a hipertensão arterial, diabetes mellitus,
Publicado em: 2007
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17. Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
American Diabetes Association.
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18. The Extrapancreatic Effects of Glucagon-Like Peptide-1 and Related Peptides
Context: Glucagon-like peptide-1 (GLP-1) 7-36 amide, an insulinotropic hormone released from the intestinal L cells in response to nutrient ingestion, has been extensively reviewed with respect to β-cell function. However GLP-1 receptors are abundant in many other tissues. Thus, the function of GLP-1 is not limited to the islet cells, and it has regulatory
The Endocrine Society.
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19. Hepatic and glucagon-like peptide-1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated in the etiology of this condition; however, effective therapies to block glucagon signaling and thereby regulate glucose metabolism do not exist. To determine the extent to which blocking glucagon action would r
American Society for Clinical Investigation.
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20. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.
Insulin secretion is controlled by a complex set of factors that include not only glucose but amino acids, catecholamines, and intestinal hormones. We report that a novel glucagon-like peptide, co-encoded with glucagon in the glucagon gene is a potent insulinotropic factor. The glucagon gene encodes a proglucagon that contains in its sequence glucagon and ad
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21. Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
Proglucagon is processed differentially in the pancreatic alpha cells and the intestinal L cells to yield either glucagon or glucagon-like peptide 1, respectively, structurally related hormones with opposing metabolic actions. Here, we have studied the processing of proglucagon in alpha TC1-6 cells, an islet-cell line transformed by simian virus 40 large tum
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22. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.
Glucagon-like peptide 1 (GLP-1) is a hormone derived from the preproglucagon molecule and is secreted by intestinal L cells. It is the most potent stimulator of glucose-induced insulin secretion and also suppresses in vivo acid secretion by gastric glands. A cDNA for the GLP-1 receptor was isolated by transient expression of a rat pancreatic islet cDNA libra
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23. Identification of the glucagon receptor in rat liver membranes by photoaffinity crosslinking
The photoaffinity crosslinker hydroxysuccinimidyl-p-azidobenzoate was used to attach 125I-labeled glucagon covalently to a rat liver membrane protein of Mr ≈ 53,000. Membranes that had been incubated with 125I-labeled glucagon were treated in the dark with hydroxysuccinimidyl-p-azidobenzoate, and a covalent complex was then formed by irradiation with ultra
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24. Glucagon-like peptide 1 improved glycemic control in type 1 diabetes
BioMed Central.