Genomics
Mostrando 1-12 de 915 artigos, teses e dissertações.
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1. The impact of pre-existing thyroid diseases on susceptibility to respiratory infections or self-reported sickness during the SARS-CoV-2 pandemic
ABSTRACT Introduction: This study aimed to evaluate the incidence, severity and presence of symptoms of respiratory tract infections and COVID-19, in patients with pre-existing thyroid dysfunction compared to individuals without thyroid diseases, during the peak month of the COVID-19 pandemic in the Netherlands. Subjects and methods: In this retrospective
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Genetics of COVID-19
Abstract Objective This narrative, non-systematic review provides an update on the genetic aspects of the SARS-CoV-2 virus and its interactions with the human genome within the context of COVID-19. Although the main focus is on the etiology of this new disease, the genetics of SARS-CoV-2 impacts prevention, diagnosis, prognosis, and the development of thera
J. Pediatr. (Rio J.). Publicado em: 2021-08
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3. What can we learn from measuring IgE to allergens and allergen components in tropical and subtropical settings in Brazil?
Abstract Objective This narrative, non-systematic review provides an update on the genetic aspects of the SARS-CoV-2 virus and its interactions with the human genome within the context of COVID-19. Although the main focus is on the etiology of this new disease, the genetics of SARS-CoV-2 impacts prevention, diagnosis, prognosis, and the development of thera
J. Pediatr. (Rio J.). Publicado em: 2021-08
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4. Nutritional genomics, inflammation and obesity
ABSTRACT The Human Genome Project has significantly broadened our understanding of the molecular aspects regulating the homeostasis and the pathophysiology of different clinical conditions. Consequently, the field of nutrition has been strongly influenced by such improvements in knowledge – especially for determining how nutrients act at the molecular leve
Arch. Endocrinol. Metab.. Publicado em: 2020-06
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5. Competency Profile in Genetics for Physicians in Brazil: A Proposal of the Brazilian Society of Medical Genetics and Genomics
RESUMO Educação em genética é fundamental para o entendimento dos aspectos biológicos do binômio saúde-doença. Além disso, com a mudança do perfil epidemiológico, as doenças com determinantes genéticos tornaram-se mais relevantes como problema de saúde pública. Assim, manejar estas doenças, tanto em pacientes como em suas famílias, de forma
Rev. bras. educ. med.. Publicado em: 13/01/2020
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6. Population genomics and gene introgression in goat herds naturally adapted to Brazil
RESUMO Objetivou-se aplicar Chip SNP caprinos 50 K da Illumina para analisar a estrutura genômica populacional em dois rebanhos de caprinos Marota, um particular e outro de conservação oficial, localizados no Piauí, e na investigação de indícios de erosão genética provocada pela raça Anglonubiana nesses rebanhos. Para isso, 86 animais Marota e 10 A
Rev. Ciênc. Agron.. Publicado em: 04/07/2019
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7. Whole-genome duplication and hemoglobin differentiation traits between allopatric populations of Brazilian Odontophrynus americanus species complex (Amphibia, Anura)
Abstract Two allopatric populations of Brazilian diploid and tetraploid Odontophrynus americanus species complex, both from São Paulo state, had their blood hemoglobin biochemically analyzed. In addition, these specimens were cytogenetically characterized. Biochemical characterization of hemoglobin expression showed a distinct banding pattern between the al
Genet. Mol. Biol.. Publicado em: 27/06/2019
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8. Combined pituitary hormone deficiency caused by PROP1 mutations: update 20 years post-discovery
ABSTRACT The first description of patients with combined pituitary hormone deficiencies (CPHD) caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and genetic characteristics of patients with PROP1 mutations and summarized the phenotypes of 14 patients with 7 different pathogenic PROP1 mutations followed at the Hospital das Clínica
Arch. Endocrinol. Metab.. Publicado em: 13/05/2019
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9. Medicina de precisão/medicina personalizada: análise crítica dos movimentos de transformação da biomedicina no início do século XXI
O grande desenvolvimento da pesquisa em genômica nas últimas décadas tem gerado muitas expectativas com relação ao seu impacto na biomedicina. Observa-se o crescente investimento em pesquisa na medicina personalizada ou de precisão, que busca customizar a prática médica com foco no indivíduo baseando-se na utilização de testes genéticos, identifi
Cad. Saúde Pública. Publicado em: 25/03/2019
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10. Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential
The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent deca
Clinics. Publicado em: 21/03/2019
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11. Evaluation of three recombinant proteins for the development of ELISA and immunochromatographic tests for visceral leishmaniasis serodiagnosis
BACKGROUND Visceral Leishmaniasis (VL) is an infectious disease that is a significant cause of death among infants aged under 1 year and the elderly in Brazil. Serodiagnosis is a mainstay of VL elimination programs; however, it has significant limitations due to low accuracy. OBJECTIVE This study aimed to evaluate three recombinant Leishmania infantum pr
Mem. Inst. Oswaldo Cruz. Publicado em: 04/02/2019
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12. Nutritional and health benefits of legumes and their distinctive genomic properties
Abstract Legumes are indispensable for human diet in respect to their valuable and nutritive bioactive molecules. Legumes and derivative foodstuffs are rich in fiber, proteins, vitamins and some valuable phytochemicals, which exhibit important biological activities. Due to their remarkable molecular content, they are receiving great attention by researchers
Food Sci. Technol. Publicado em: 07/01/2019