Genome Variations
Mostrando 1-12 de 239 artigos, teses e dissertações.
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1. Cytological and genome size data analyzed in a phylogenetic frame: Evolutionary implications concerning Sisyrinchium taxa (Iridaceae: Iridoideae)
Abstract Sisyrinchium is the largest genus of Iridaceae in the Americas and has the greatest amount of cytological data available. This study aimed at investigating how genomes evolved in this genus. Chromosome number, genome size and altitude from species of sect. Viperella were analyzed in a phylogenetic context. Meiotic and pollen analyses were performed
Genet. Mol. Biol.. Publicado em: 01/03/2018
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2. Mycobacterium tuberculosis promotes genomic instability in macrophages
BACKGROUND Mycobacterium tuberculosis is an intracellular pathogen, which may either block cellular defensive mechanisms and survive inside the host cell or induce cell death. Several studies are still exploring the mechanisms involved in these processes. OBJECTIVES To evaluate the genomic instability of M. tuberculosis-infected macrophages and compare it
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-03
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3. Cytogenomic assessment of the diagnosis of 93 patients with developmental delay and multiple congenital abnormalities: The Brazilian experience
OBJECTIVE: The human genome contains several types of variations, such as copy number variations, that can generate specific clinical abnormalities. Different techniques are used to detect these changes, and obtaining an unequivocal diagnosis is important to understand the physiopathology of the diseases. The objective of this study was to assess the diagno
Clinics. Publicado em: 2017-09
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4. Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis
BACKGROUND Leishmanolysins have been described as important parasite virulence factors because of their roles in the infection of promastigotes and resistance to host’s defenses. Leishmania (Viannia) braziliensis contains several leishmanolysin genes in its genome, especially in chromosome 10. However, the functional impact of such diversity is not under
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-09
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5. Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration
Abstract Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim of this study was to determine the HBV genotypes and subgenotypes circulating in Southeast Brazil and compare the genetic sequences found with HBV sequences previously described in the world. Sequences from 166 chro
Braz J Infect Dis. Publicado em: 2017-08
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6. Phylogenetic analyses of chikungunya virus among travelers in Rio de Janeiro, Brazil, 2014-2015
Chikungunya virus (CHIKV) is a mosquito-borne pathogen that emerged in Brazil by late 2014. In the country, two CHIKV foci characterized by the East/Central/South Africa and Asian genotypes, were established in North and Northeast regions. We characterized, by phylogenetic analyses of full and partial genomes, CHIKV from Rio de Janeiro state (2014-2015). The
Mem. Inst. Oswaldo Cruz. Publicado em: 29/03/2016
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7. Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1
Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is still endemic in many regions of the world and a public health problem in Brazil. The prevalence rate in 2011 reached 1.54 cases per 10,000 inhabitants in Brazil. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetic
An. Bras. Dermatol.. Publicado em: 2014-04
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8. SNPs genotyping technologies and their applications in farm animals breeding programs: review
Single nucleotide polymorphisms (SNPs) are DNA sequence variations that occur when a single nucleotide: adenine (A), thymine (T), cytosine (C) or guanine (G) in the genome sequence is altered. Traditional and high throughput methods are two main strategies for SNPs genotyping. The SNPs genotyping technologies provide powerful resources for animal breeding pr
Braz. arch. biol. technol.. Publicado em: 2014-02
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9. Investigating he signature of natural selection on exonic splicing regulators of the human genome / Análise dos sinais de seleção natural em reguladores de splicing exônicos do genoma humano
Splicing is the process by which introns are removed from a mRNA precursor and exons are ligated to form a mature mRNA. During this process several cis and trans factors are involved. Besides the canonical cis factors (e.g., splicing sites, branch point and polypyrimidine tract), Splicing Regulators - short sequences located in exons and introns - have an im
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/06/2012
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10. Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
Vaccine development faces major difficulties partly because of genetic variation in both infectious organisms and humans. This causes antigenic variation in infectious agents and a high interindividual variability in the human response to the vaccine. The exponential growth of genome sequence information has induced a shift from conventional culture-based to
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-05
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11. The TP53 fertility network
The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed "guardian of the genome", TP53 occupies a central node in stress response networks. The p53 protein has a key role as transcr
Genet. Mol. Biol.. Publicado em: 2012
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12. Taxonomia das espécies sul-brasileiras de Calydorea Herbert (Iridaceae) e caracterização por DNA "Barcode"
This study aimed a taxonomic revision of the genus Calydorea from southern Brazil, providing the basis for identification of the species, by means of a dichotomous key, illustrations and images of plants in the natural environment. Another aim was to verify the effectiveness of use of target gene sequences to discriminate species, in the light of the propose
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012