Genic Expression
Mostrando 13-24 de 54 artigos, teses e dissertações.
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13. Ácido fólico: efeitos paradoxais na promoção da hepatocarcinogênese em ratos / Folic acid: paradoxical effects during promotion of hepatocarcinogenesis in rats.
Folic acid (FA) supplementation shows chemopreventive effects, however, it may increase the risk of development and accelerate cancer progression in case of high doses or after preneoplastic lesions (PNL) are established. FA is essential on de novo synthesis of purine and thymidalate and, consequently, on DNA synthesis, replication and repair, cell prolifera
Publicado em: 2010
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14. Alterações celulares, moleculares e funcionais de fígados de ratas Wistar tratadas com fatores hepatotróficos / Cellular, molecular and functional alterations in rat liver treated with hepatotrophic factors
Fatores hepatotróficos (FH) possuem a capacidade de promover aumento de massa hepática em ratos e diminuição da fibrose em animais cirróticos. Os FH podem ser importantes nos casos de ressecção e transplantes hepáticos no qual o fígado remanescente necessita de um volume considerável para exercer suas funções após a cirurgia. Objetivou-se neste
Publicado em: 2010
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15. Análise das células inflamatórias e da proteína anexina 1 no modelo de artrite experimental e reumatóide humana. / Analysis of the inflammatory cells and annexin 1 protein in the experimental model arthritis and in the human rheumatoid .
Rheumatoid arthritis (RA) is a disease characterized by auto-antibody formation, chronic inflammation and joint oedema resulting in injury of affected cartilage and adjacent bone. In the treatment of this disease glucocorticoids (GC) have been used, wich induce genic expression of anti-inflammatory mediators, such as the annexin 1 protein (Anx-A1), and proin
Publicado em: 2010
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16. Resistência à ferrugem do cafeeiro: mapeamento genético, físico e análise da expressão gênica em resposta a infecção de H. vastatrix / Coffea leaf rust: genetic, physical mapping and analysis of the gene expression in response to infection the H. vastatrix
The coffee leaf rust it is caused by the biothrofic fungus Hemileia vastatrix is one diseases that more it causes economical damages. The coffee breeding for obtaining for resistance plants it is slow and the moleculars studies of identification for resistance genes to H. vastatrix are still few informative. This study had as objective to obtain information
Publicado em: 2009
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17. Identificação de genes associados a produção de ocratoxina A em Aspergillus westerdijkiae
Mycotoxins, secondary metabolites of fungi, are toxic compounds found in great variety of foods, and when ingested can be very hazardous to animal and human health. Among the diverse mycotoxins, special interest has been given to the ochratoxin A (OA), produced by some species of Aspergillus and Penicillium. This mycotoxin is frequently found mainly in food
Publicado em: 2009
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18. Genic transfer in sperm cells in Mus musculus and Ramdia quelem / Transferência gênica em células espermáticas de Mus musculus e Ramdia quelen
Transgenic animals have been used as biological models in studies of the genes functions and their mechanisms of action, as well as to improve animal production. Researchers are trying to produce transgenic animals that will be organs donors in xenotransplants. Another use of the transgenic animal is in the production of recombinant proteins for pharmaceutic
Publicado em: 2009
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19. Genic expression alterations in the tolerance to LPS : B lymphocyte in the genic regulation of the tolerance / Alterações de expressão gênica na tolerância ao LPS: análise da participação dos linfócitos B na regulação gênica da tolerância
Sepses are caused by microorganisms such as: Gram-negative bacteria, Gram-positive bacteria, fungus and virus. Several sepses and the septic shock have been associated with the mortality rates from 40 to 60%. One of the most important events for the septic evolution is the apoptosis cells of the immune system. The cells immune system elimination compromises
Publicado em: 2008
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20. Genic expression of uterine leiomyoma in women during the reproductive age after treatment with agonist GnRH analogue / Expressão gênica do leiomioma uterino em mulheres no período reprodutivo após tratamento com análogo agonista do GnRH
OBJECTIVE: To identify the genes differentially expressed between the uterine leiomyomas of patients in reproductive age, treat or not treated with GnRH analogue and confirm the results for genes selected by real time PCR. METHODS: It was harvested sample of the largest lump of uterine leiomyoma of 89 black patients, aged between 20 and 45 years, with detail
Publicado em: 2008
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21. Expression of gap junction proteins, the connexins, in normal and neoplastic osseous tissues from dogs / Estudo da expressão das proteínas de junções intercelulares do tipo Gap, as conexinas, em tecido ósseo normal e neoplásico de cães
Increasing evidence indicates that junctional communiction by gap juctions has a critical role in a bone physiology. The main connexin (Cx) express involved in development, differentiation and regulation of tissue growth, is the called Cx43. However, other, two connexis are expressed: Cx45 and Cx46. Cx46 is retained as monomers in a trans-golgi compartment o
Publicado em: 2008
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22. Clinical and biochemical alterations secondary to chronic unpredictable stress and oxidative stress in rats. / Alterações clínicas e bioquímicas decorrentes do estresse crônico imprevisível e do estresse oxidativo em ratos.
The study of stress effects in different animal models help to clarify signalization mechanisms involved in human diseases. The present project was divided in two parts. Firstly, we investigated the effects of chronic unpredictable stress (CUS) on the course of experimental autoimmune encephalomyelitis (EAE) and circulating corticosterone (CORT) concentratio
Publicado em: 2008
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23. Toxicidade da polimixina B em células LLC-PK1 e a enzima heme oxigenase-1 / Polymyxin B toxicity in LLC-PK1 cells and the heme oxygenase-1 enzyme
In the acute kidney injury, the mechanisms of defense act as protector genes, as the protein heat shock 32 (HSP 32), also known as heme oxygenase-1 (HO-1). The polymyxin B (PmxB) is a nephrotoxic antimicrobial. The aim of this study was to distinguish the role of the HO-1 enzyme in the PmxB toxicity in LLC-PK1 cells. The cells were submitted to the following
Publicado em: 2008
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24. Estudo do sistema neuroimunoendócrino na caquexia neoplásica e da resposta ao tratamento com esteróides
The anorexia-cachexia syndrome (ACS), of multifactorial source and complex, is common in chronic diseases, like advanced cancer. Is associated with weight loss and decrease food intake, sometimes causing death. The objective of the present study was to evaluate the influence of neoplastic cachexia over the hypothalamus-pituitary-adrenal axis and immune syste
Publicado em: 2008