Gene Mll
Mostrando 1-12 de 82 artigos, teses e dissertações.
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1. AvaliaÃÃo dos genes MLL, RB e TP53 em pacientes com sÃndrome mielodisplÃsica / Evaluation of genes MLL, RB and TP53 in patients with Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal disorders affecting the hematopoietic pluripotent cell, characterized by low cell counts in peripheral blood, dysplasia in one or more cell lines, inefficient hematopoiesis and increased risk of progression to acute myeloid leukemia. Although the disease can affect patients of other ag
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/06/2011
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2. MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals
Chromosomal translocations are characteristic of hematopoietic neoplasias and can lead to unregulated oncogene expression or the fusion of genes to yield novel functions. In recent years, different lymphoma/leukemia-associated rearrangements have been detected in healthy individuals. In this study, we used inverse PCR to screen peripheral lymphocytes from 10
Genetics and Molecular Biology. Publicado em: 2009
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3. Preferential induction of MLL (Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide
Topoisomerase II inhibitors are effective chemotherapeutic agents in the treatment of cancer, in spite of being associated with the development of secondary leukemia. Our purpose was to determine the effects of etoposide on different genomic regions, aiming at discovering whether there are preferential sites which can be targeted by this drug in peripheral l
Genetics and Molecular Biology. Publicado em: 2009
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4. Acute leukemia in early childhood
Acute leukemia in early childhood is biologically and clinically distinct. The particular characteristics of this malignancy diagnosed during the first months of life have provided remarkable insights into the etiology of the disease. The pro-B, CD10 negative immunophenotype is typically found in infant acute leukemia, and the most common genetic alterations
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-06
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5. Phnotipic and molecular features of acute lymphoblastic leukemia in Recife - PE / Avaliação imunofenotipica, estudo do indice de DNA e de alterações moleculares em celulas blasticas de pacientes portadores de leucemia linfoide aguda diagnosticados na Fundação Hemope
Acute Lymphoblastic Leukemia (ALL) is a disease that occurs primarily in children (75-80%) and represents only 20% of adults leukemia. Some c1inical and laboratorial research have focused on stratifying patients into various risk groups based on known prognostic features that play a critical role in directing therapy for ALL. We have studied biological chara
Publicado em: 2007
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6. Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia
Infant acute lymphoblastic leukemia (IALL) is characterized by mixed lineage leukemia (MLL) gene rearrangements, unique gene expression profiles, poor prognosis, and drug resistance. One exception is cytosine arabinoside (Ara-C) to which IALL cells seem to be more sensitive. We quantified mRNA expression of Ara-C key enzymes in leukemic lymphoblasts from 64
Brazilian Journal of Medical and Biological Research. Publicado em: 25/09/2006
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7. Alterações moleculares em síndrome mielodisplásica
A síndrome mielodisplásica (SMD) representa um grupo heterogêneo de doenças hematopoéticas clonais. As alterações cromossômicas observadas em SMD foram o ponto de partida para uma série de estudos para a caracterização da patogênese molecular nessa doença. A perda de material genético leva à hipótese de inativação de genes supressores tumor
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2006-09
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8. CML transcriptome analysis using ORESTES (Open Reading Frame Expression Sequence Tags) / Avaliação do transcriptoma da leucemia mieloide cronica por ORESTES (Open Reading Frame Expression Sequence Tags)
The complete collection of transcripts generated from the human genome cannot be predicted from the genome sequence, but should be directly determined for each tissue, due to variations of gene expression in different tissues and disease states, and because genes can encode multiple transcripts derived from alternate splicing and polyadenylation sites. As pa
Publicado em: 2003
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9. As bases moleculares da leucemia mielóide aguda
A leucemia mielóide aguda (LMA) está freqüentemente associada a translocações cromossômicas recorrentes. Em muitos casos, os genes presentes nos pontos de quebra cromossômica são conhecidos e, quase todos codificam para fatores de transcrição. O gene híbrido, resultante da justaposição de exons de genes distintos, codifica para proteínas de fus
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2002
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10. Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors
Leukemias with MLL gene translocations are a complication of primary cancer treatment with DNA topoisomerase II inhibitors. How early translocations appear during primary cancer treatment has not been investigated. We tracked the leukemic clone with an MLL gene translocation during neuroblastoma therapy in a child who developed acute myeloid leukemia. T
The National Academy of Sciences.
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11. The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression
MLL, involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia, has >50 known partner genes with which it is able to form in-frame fusions. Characterizing important downstream target genes of MLL and of MLL fusion proteins may provide rational therapeutic strategies for the treatment of MLL-associated leukemia. We explor
National Academy of Sciences.
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12. MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
Determinative events in vertebrate embryogenesis appear to require the continuous expression of spatial regulators such as the clustered homeobox genes. The mechanisms that govern long-term patterns of gene expression are not well understood. In Drosophila, active and silent states of developmentally regulated loci are maintained by trithorax and Polycomb gr
The National Academy of Sciences.