Fusion Inhibitor
Mostrando 1-12 de 406 artigos, teses e dissertações.
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1. The complex translocation (9;14;14) involving IGH and CEBPE genes suggests a new subgroup in B-lineage acute lymphoblastic leukemia
Abstract Many subtypes of acute lymphoblastic leukemia (ALL) are associated with specific chromosomal rearrangements. The complex translocation t(9;14;14), a variant of the translocation (14;14)(q11;q32), is a rare but recurrent chromosomal abnormality involving the immunoglobulin heavy-chain (IGH) and CCAAT enhancer-binding protein (CEBPE) genes in B-lineag
Genet. Mol. Biol.. Publicado em: 2016-03
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2. FGF2 species of 18 and 22.5 kDa: paracrine molecular signaling and biological functions / FGF2 de 18kDa e de 22,5kDa: sinalização molecular parácrina e funções biológias
FGF2 (Fibroblast Growth Factor 2), the founder of the FGF family, has regulatory functions in mitogenesis, differentiation, morphogenesis and tissue repair. Multiple FGF2 molecular species, sharing a C-terminal sequence of 155 amino acids, are translated from different iniciation sites of the same mRNA. The smaller, the FGF2-18kD, is extracellularly released
Publicado em: 2010
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3. Avaliação da sensibilidade aos inibidores de entrada do HIV-1 em pacientes em falha virológica à terapia antirretroviral e novos aos inibidores de entrada. / Evaluation of sensitivity to inhibitors of entry of HIV-1 in patients with virological failure to antiretroviral therapy and new inhibitors of the entry.
Introduction: The chance of using combination of drugs within Highly Active Antiretroviral Therapy (HAART) has been resulted in a dramatic fall in the mortality and morbidity caused by the Human Immunodeficiency Virus-1 (HIV-1). Nevertheless, over the past years, there was observed a selection of strains resistant to some of these drugs, and today constitute
Publicado em: 2009
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4. Avaliação da resistência genotípica ao Enfuvirtida em pacientes submetidos ao HAART. Fenotipagem virtual das cepas de HIV1 isoladas de trinta e dois pacientes que apresentaram resistência aos antirretrovirais / Evaluation of the genotypic resistance associated to Enfuvirtide (ENF) in patients submitted to HAART. Virtual Phenotypic Assay in thirty-two isolated HIV1 strains of the patients that presented resistance to antiretroviral
Introdução: estudos com Enfuvirtida (ENF) mostraram que mutações na HR1 da gp41 levam à resistência primária de cepas em pacientes sem tratamento prévio com inibidores de fusão (Derdeyn et al., 2000; Rimsky et. al., 1998; Sista et. al., 2002). Outros, que o uso contínuo de HAART leva à falha virológica (Shafer et. al., 1998; Shafer &Vuitton, 1999
Publicado em: 2009
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5. Prolactina induz aumento na expressão das proteinas SNARE e da sinaptotagmina 4 em ilhotas de ratos
The soluble N-ethylmaleimide-sensitive factor attached protein receptor (SNARE) molecules SNAP-25, syntaxin and VAMP-2 as well as synaptotagmins participate in the extrusion of insulin containing granules in pancreatic β -cells. During pregnancy and the perinatal periods of life, prolactin (PRL) and other lactogenic substances induce maturation of the s
Publicado em: 2004
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6. Tubulin is the endogenous inhibitor of the glyceraldehyde 3-phosphate dehydrogenase isoform that catalyzes membrane fusion: Implications for the coordinated regulation of glycolysis and membrane fusion
Previously we demonstrated that specific chromatographically resolvable isoforms of rabbit brain GAPDH catalyze either glycolytic flux or membrane fusion activity (but not both). Moreover, GAPDH membrane fusion activity was latent until it was separated from an endogenous cytosolic inhibitor by anion-exchange chromatography. Herein we demonstrate that the cy
National Academy of Sciences.
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7. Impact of Mutations in the Coreceptor Binding Site on Human Immunodeficiency Virus Type 1 Fusion, Infection, and Entry Inhibitor Sensitivity
An increasingly large number of antiviral agents that prevent entry of human immunodeficiency virus (HIV) into cells are in preclinical and clinical development. The envelope (Env) protein of HIV is the major viral determinant that affects sensitivity to these compounds. To understand how changes in Env can impact entry inhibitor sensitivity, we introduced s
American Society for Microbiology.
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8. Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion
Trimeric class I virus fusion proteins undergo a series of conformational rearrangements that leads to the association of C- and N-terminal heptad repeat domains in a “trimer-of-hairpins” structure, facilitating the apposition of viral and cellular membranes during fusion. This final fusion hairpin structure is sustained by protein–protein interactions
National Academy of Sciences.
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9. Specific Inhibition of Human Cytomegalovirus Glycoprotein B-Mediated Fusion by a Novel Thiourea Small Molecule
A novel small molecule inhibitor of human cytomegalovirus (HCMV) was identified as the result of screening a chemical library by using a whole-virus infected-cell assay. Synthetic chemistry efforts yielded the analog designated CFI02, a compound whose potency had been increased about 100-fold over an initial inhibitor. The inhibitory concentration of CFI02 i
American Society for Microbiology.
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10. I2B is a small cytosolic protein that participates in vacuole fusion
Saccharomyces cerevisiae vacuole inheritance requires two low molecular weight activities, LMA1 and LMA2. LMA1 is a heterodimer of thioredoxin and protease B inhibitor 2 (I2B). Here we show that the second low molecular weight activity (LMA2) is monomeric I2B. Though LMA2/I2B was initially identified as a protease B inhibitor, this protease inhibitor activit
The National Academy of Sciences of the USA.
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11. Orthopoxvirus fusion inhibitor glycoprotein SPI-3 (open reading frame K2L) contains motifs characteristic of serine proteinase inhibitors that are not required for control of cell fusion.
The cowpox virus (CPV) SPI-3 gene (open reading frame K2L in vaccinia virus) is one of three orthopoxvirus genes whose products are members of the serpin (serine proteinase inhibitor) superfamily. The CPV SPI-3 gene, when overexpressed by using the vaccinia virus/T7 expression system, synthesized two proteins of 50 and 48 kDa. Treatment with the N glycosylat
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12. Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity.
Past efforts to employ a structure-based approach to design an inhibitor of the fusion-inducing conformational change in the influenza virus hemagglutinin (HA) yielded a family of small benzoquinones and hydroquinones. The most potent of these, tert-butyl hydroquinone (TBHQ), inhibits both the conformational change in HA from strain X:31 influenza virus and