Free Radical Scavengers
Mostrando 1-12 de 57 artigos, teses e dissertações.
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1. Role of Natural Antioxidants in the Modulation of Plasma Amino Acid Pattern in Rats Exposed to Hemic Hypoxia
ABSTRACTThe aim of this work was to investigate whether the free radical scavengers, L-arginine (L-arg) and/or carnosine, either alone, or in combination would modulate tissue injury induced by hypoxia by measuring Fischer's ratio [concentrations of branched chain amino acids (BCAAs)/aromatic amino acids]. Decreased Fischer's ratios and increased malondialde
Braz. arch. biol. technol.. Publicado em: 2015-10
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2. EFEITO DE Paullinia cupana (Mart.) NO ESTRESSE OXIDATIVO INDUZIDO PELO NITROPRUSSIATO DE SÓDIO EM CELÚLAS DE FIBROBLASTOS EMBRIONÁRIOS NIH-3T3 / Paullinia cupana (Mart.) EFFECT ON OXIDATIVE STRESS SODIUM NITROPRUSSIDE INDUCED IN EMBRYONIC FIBROBLAST NIH-3T3 CELLS
Os efeitos antioxidantes do extrato hidro-alcoólico de guaraná (Paullinia cupana var. sorbilis) sobre o Óxido Nítrico (NO) e outros compostos gerados a partir da decomposição do Nitroprussiato de Sódio (NPS) em cultura de fibroblastos embriônicos (NIH 3T3) foram avaliados. Os compostos bioativos do guaraná foram inicialmente determinados por cromato
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/04/2011
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3. Effects of dimethylsulfoxide, lipoic acid or ternatin pretreatment upon the oxidative stress in young rats subjected to torsion of the spermatic cord / Efeitos do pré-tratamento com dimetilsufóxido, ácido lipóico ou ternatina sobre o estresse oxidativo
The protective role of dimethylsulfoxide (DMSO), lipoic acid (LA) and ternatin (TN), known free radical scavengers and cell membrane protectants were evaluated in an experimental model of testis ischemia/reperfusion. One hundred and twenty young male Wistar rats, mean weight 172.515g, were randomized in five equal groups (GS - Sham, GC Control, GD Dimethylsu
Publicado em: 2005
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4. Estudos visando a sÃntese de hÃbridos de tocoferol com Ãcido ascÃrbico
The antioxidant activity of tocopherol and ascorbic acid, as well as the capacity of the latter to regenerate tocopherol from the tocopheroxyl radical has generated great interest in the synthesis of hybrid molecules containing both of the above moieties in the same molecule. We term such species as potentially autoregenerable radical scavengers. With the in
Publicado em: 2003
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5. Coronary endothelial dysfunction after ischemia and reperfusion: a new therapeutic target?
Although cardiac ischemia is usually characterized as a disease of the myocyte, it is clear that the vasculature, and especially endothelial cells, is also a major target of this pathology. Indeed, using a rat model of ischemia/reperfusion, we were able to detect severe endothelial dysfunction (assessed as a decreased response to acetylcholine) after acute o
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-01
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6. Hydroxyl radical scavengers inhibit lymphocyte mitogenesis.
Agents that are known to be scavengers of hydroxyl radicals inhibit lymphocyte mitogenesis induced by phorbol myristate acetate (PMA) to a greater extent than they inhibit mitogenesis induced by concanavalin A or phytohemagglutinin. These agents include dimethyl sulfoxide, benzoate, thiourea, dimethylurea, tetramethylurea, L-tryptophan, mannitol, and several
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7. Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones.
The cytotoxicity of the clinically important antineoplastic quinones doxorubicin, mitomycin C, and diaziridinylbenzoquinone for the Ehrlich ascites carcinoma was significantly reduced or abolished by the antioxidant enzymes catalase and superoxide dismutase, the hydroxyl radical scavengers dimethyl sulfoxide, diethylurea, and thiourea, and the iron chelators
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8. Inhibition of the Conversion of 1-Aminocyclopropane-1-carboxylic Acid to Ethylene by Structural Analogs, Inhibitors of Electron Transfer, Uncouplers of Oxidative Phosphorylation, and Free Radical Scavengers 1
Cyclopropane carboxylic acid (CCA) at 1 to 5 millimolar, unlike related cyclopropane ring analogs of 1-aminocyclopropane-1-carboxylic acid (ACC) which were virtually ineffective, inhibited C2H4 production, and this inhibition was nullified by ACC. Inhibition by CCA is not competitive with ACC since there is a decline, rather than an increase, in native endog
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9. Effect of free-radical scavengers on enumeration of thermally stressed cells of Staphylococcus aureus MF-31.
Exposure of crude cell lysates of Staphylococcus aureus MF-31 to 5 or 10 mM hydrogen peroxide resulted in a linear decrease in superoxide dismutase activity. Approximately 13% of the superoxide dismutase activity was lost after 16 min. Thermally stressed and nonstressed cells were exposed to a photochemically generated exogenous flux of superoxide radicals (
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10. Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats.
The protective effect of hydroxyl radical scavengers and iron chelators has strongly implicated the hydroxyl radical in several models of tissue injury. Based on in vitro studies showing gentamicin-enhanced generation of reactive oxygen metabolites in renal cortical mitochondria, we examined the effect of hydroxyl radical scavengers and iron chelators in gen
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11. Carboxyfullerenes as neuroprotective agents
Two regioisomers with C3 or D3 symmetry of water-soluble carboxylic acid C60 derivatives, containing three malonic acid groups per molecule, were synthesized and found to be equipotent free radical scavengers in solution as assessed by EPR analysis. Both compounds also inhibited the excitotoxic death of cultured cortical neurons induced by exposure to N-meth
The National Academy of Sciences of the USA.
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12. Chlorophyll Destruction by the Bisulfite-Oxygen System 1
Destruction of chlorophyll, as determined by the loss in absorbance at 665 nm, occurred in two in vitro systems in the presence of bisulfite in 76% ethanol. The first system required light and O2 in addition to bisulfite and exhibited an optimum pH of 4. Chlorophyll functioned as a photosensitizer and there was little chlorophyll destruction occurring above