Focal Adhesion
Mostrando 1-12 de 384 artigos, teses e dissertações.
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1. Paralisia facial como complicação neurológica da SARS-CoV-2
Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pharmacological therapy. Herein, we investigated the impli
Arq. Neuro-Psiquiatr.. Publicado em: 2020-10
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2. Role of FAK signaling in chagasic cardiac hypertrophy
Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pharmacological therapy. Herein, we investigated the impli
Braz J Infect Dis. Publicado em: 2020-10
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3. Small RNA sequencing reveals microRNAs related to neuropathic pain in rats
The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles in the pathogenesis and development process of neuropathic pain. The rat model of neuropathic pain caused by spared nerve injury (SNI) was established in Sprague-Dawley male rats, followed by small RNA sequencing of the L3–L6 d
Braz J Med Biol Res. Publicado em: 16/09/2019
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4. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
BACKGROUND Cardiac physiology depends on coupling and electrical and mechanical coordination through the intercalated disc. Focal adhesions offer mechanical support and signal transduction events during heart contraction-relaxation processes. Talin links integrins to the actin cytoskeleton and serves as a scaffold for the recruitment of other proteins, suc
Mem. Inst. Oswaldo Cruz. Publicado em: 15/08/2019
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5. Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells
Abstract Background Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression and activity has been previously suggested. However, the m
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/05/2018
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6. Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome
In this study, biomarkers and transcriptional factor motifs were identified in order to investigate the etiology and phenotypic severity of Down syndrome. GSE 1281, GSE 1611, and GSE 5390 were downloaded from the gene expression ominibus (GEO). A robust multiarray analysis (RMA) algorithm was applied to detect differentially expressed genes (DEGs). In order
Braz J Med Biol Res. Publicado em: 08/08/2014
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7. PTK2 and PTPN11 expression in myelodysplastic syndromes
OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS: Protei
Clinics. Publicado em: 2013-10
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8. Utilização farmacológica de um composto inédito derivado de quinazolina como inibidor potencial da quinase de adesão focal (FAK) no processo de hipertrofia cardíaca em camundongo = : Pharmacological use of a novel compound quinazoline derivative as potential inhibitor of the focal adhesion kinase in the process of cardiac hypertrophy in mice / Pharmacological use of a novel compound quinazoline derivative as potential inhibitor of the focal adhesion kinase in the process of cardiac hypertrophy in mice
Nas doenças do coração ocorre hipertrofia e remodelamento do ventrículo esquerdo com impacto negativo na evolução clínica. Esses fatores influenciam independentemente o risco cardiovascular por elevarem a predisposição a infartos do miocárdio, ao desenvolvimento de insuficiência cardíaca e ao aparecimento de arritmias ventriculares graves. Estrut
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/07/2012
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9. Inibição da migração mediada pelo gene RECK em modelo de glioma humano através de alterações no citoesqueleto e adesão focal / RECK-mediated inhibition of glioma migration with changes in cytoskeleton and focal adhesion
Gliomas são tumores altamente invasivos, resistentes aos tratamentos disponíveis atualmente e com alta taxa de mortalidade. A superexpressão de RECK na linhagem de glioma humano T98G comprometeu a capacidade das células de migrar e invadir in vitro, com rearranjo do citoesqueleto e alteração na distribuição espacial de FAK fosforilado. Entretanto, o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/05/2012
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10. The meanings ascribed to falling ill and to treatment by high blood pressure carriers and health care system context: an ethnographic study / Os significados da experiência da doença e do tratamento para a pessoa com hipertensão arterial e o contexto do sistema de cuidado à saúde: um estudo etnográfico
Este estudo teve como objetivo interpretar os significados que as pessoas com hipertensão arterial sistêmica atribuem à doença e ao tratamento e à produção dos cuidados em saúde. Para interpretar tais experiências, foram adotados os referenciais da antropologia interpretativa de Clifford Geertz e da antropologia médica de Arthur Kleinman e do méto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/05/2012
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11. Interação com alfa B-cristalina protege a FAK da degradação e promove a sobrevivência de miócitos cardíacos durante estresse mecânico = : Interaction with alfa B-crystalline protects FAK degradation and promotes survival of cardiac myocytes in mechanical stress / Interaction with alfa B-crystalline protects FAK degradation and promotes survival of cardiac myocytes in mechanical stress
Diversos tipos celulares respondem ao estresse mecânico ativando sinais que culminam com remodelamento e sobrevivência. O estresse mecânico pode atuar como agente modulador da homeostase celular e de numerosos processos patológicos. Evidências sugerem que a Quinase de Adesão Focal (FAK) medeia a resposta de miócitos cardíacos ao estresse mecânico. C
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/04/2012
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12. Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis
Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulatory mechanisms involved in the aggressiveness of this cancer are still poorly understood. A better understanding of the biology, genetics and molecular mechanisms of gastric cancer would be useful in developing novel targeted approaches
Genetics and Molecular Biology. Publicado em: 13/07/2012