Fetal Therapies
Mostrando 1-12 de 26 artigos, teses e dissertações.
-
1. Fetal Cerebrospinal Fluid Promotes Proliferation and Neural Differentiation of Stromal Mesenchymal Stem Cells Derived from Bone Marrow
ABSTRACT Embryonic cerebrospinal fluid (E-CSF) contains many neurotrophic and growth factors, acts as a growth medium for cortical progenitors, and can modulate proliferation and differentiation of neural stem cells. Mesenchymal stem cells (MSCs) are multipotential stem cells that can differentiate into several types of mesenchymal cells as well as nonmesenc
Braz. arch. biol. technol.. Publicado em: 08/01/2018
-
2. Treatment of psoriasis and psoriatic arthritis during pregnancy and breastfeeding
Abstract Psoriasis is a chronic inflammatory disease that affects primarily the skin and joints, with a worldwide incidence of 2-3%. Fifty percent of patients are women, most still diagnosed during childbearing years. Currently,the estimate is that up to 107 thousand deliveries are performed annually in women with psoriasis, a percentage of them in women wit
An. Bras. Dermatol.. Publicado em: 2015-06
-
3. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter
Braz J Med Biol Res. Publicado em: 15/10/2013
-
4. Estudo do volume pulmonar fetal na predição dos resultados perinatais de fetos com derrame pleural \"isolado / Three-dimensional ultrasonographic assessment of fetal lung volume as a prognostic factor in isolated pleural effusion
OBJETIVO: O objetivo deste estudo foi predizer o prognóstico perinatal em fetos com derrame pleural isolado por meio da medida do volume pulmonar estimado pela ultrassonografia tridimensional. MÉTODO: Estudo retrospectivo, entre julho de 2005 e julho de 2010, com 19 fetos com derrame pleural isolado (ausência de causas infecciosas, imunes, anomalias cromo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
-
5. Patients with sickle cell disease taking hydroxyurea in the Hemocentro Regional de Montes Claros
BACKGROUND: The development of therapies for sickle cell disease has received special attention, particularly those that reduce the polymerization of hemoglobin S. Hydroxyurea is a commonly used medication because it has the ability to raise levels of fetal hemoglobin, decrease the frequency of vaso-occlusive episodes and thus improve the clinical course of
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011
-
6. Toxicidade causada pela cocaína in vitro: participação da via dopaminérgica e do fator de transcrição NF-kB. / In vitro cocaine toxicity: participation of the dopaminergic pathway and the transcription factor NF-kB.
Cocaine is a drug deeply used and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newly born have been demonstrated due to the toxics effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damages is very complex and involves interactions of the drug with several neurotransmitt
Publicado em: 2008
-
7. Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal / Characterization of cGMP-specific phosphodiesterases (PDE) in erythroid cells and effects PDE inhibitors on the production of fetal hemoglobin
Sickle cell disease (SCD) is a systemic disease with a multifaceted pathophysiology; the polymerisation of the sickle haemoglobin molecule (HbS), when deoxygenated, has many consequences that include haemolysis, inflammation, dysregulated nitric oxide (NO) homeostasis and oxidative abnormalities. Agents, such as hydroxyurea (HU), that increase levels of feta
Publicado em: 2006
-
8. Immunology of term and preterm labor
During pregnancy there is an alteration in maternal immunity within the uterus where innate, proinflammatory immune responses are tightly regulated to prevent immunological rejection of the fetal allograft. Disruption of the delicate balance of cytokines by bacteria or other factors increases the production of proinflammatory cytokines at the maternal-fetal
BioMed Central.
-
9. Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology
Neural and stem cell transplantation is emerging as a potential treatment for neurodegenerative diseases. Transplantation of specific committed neuroblasts (fetal neurons) to the adult brain provides such scientific exploration of these new potential therapies. Huntington's disease (HD) is a fatal, incurable autosomal dominant (CAG repeat expansion of h
The National Academy of Sciences.
-
10. Preclinical transfusion-dependent humanized mouse model of β thalassemia major
A preclinical humanized mouse model of β thalassemia major or Cooley anemia (CA) was generated by targeted gene replacement of the mouse adult globin genes in embryonic stem cells. The mouse adult α and β globin genes were replaced with adult human α globin genes (α2α1) and a human fetal to adult hemoglobin (Hb)–switching cassette (γHPFHδβ0), resp
American Society of Hematology.
-
11. Skeletal muscle stem cells
Satellite cells are myogenic stem cells responsible for the post-natal growth, repair and maintenance of skeletal muscle. This review focuses on the basic biology of the satellite cell with emphasis on its role in muscle repair and parallels between embryonic myogenesis and muscle regeneration. Recent advances have altered the long-standing view of the satel
BioMed Central.
-
12. Hydroxyurea induces fetal hemoglobin by the nitric oxide–dependent activation of soluble guanylyl cyclase
Hydroxyurea treatment of patients with sickle-cell disease increases fetal hemoglobin (HbF), which reduces hemoglobin S polymerization and clinical complications. Despite its use in the treatment of myeloproliferative diseases for over 30 years, its mechanism of action remains uncertain. Recent studies have demonstrated that hydroxyurea generates the nitric
American Society for Clinical Investigation.