Experimental Analogs
Mostrando 1-12 de 67 artigos, teses e dissertações.
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1. In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents
BACKGROUND Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10) analogs of megazol (3). OBJECTIVES To evaluate whether the genotoxic effect of 3 was abolished in the
Mem. Inst. Oswaldo Cruz. Publicado em: 27/06/2019
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2. Efeitos hemodinâmicos e metabólicos da terlipressina ou naloxona na ressuscitação cardiopulmonar: estudo experimental, randomizado e controlado / Hemodynamic and metabolic effects of terlipressin or naloxone in cardiopulmonary resuscitation: an experimental, randomized and controlled trial
Introdução: O prognóstico da parada cardiorrespiratória (PCR) em ritmo não chocável (assistolia/atividade elétrica sem pulso) é ruim e não melhorou significativamente nas últimas décadas. Embora a epinefrina seja o vasopressor recomendado, há evidências de que ela eleva o consumo de oxigênio, reduz a pressão de perfusão subendocárdica, causa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/11/2011
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3. Análogos cosmológicos dos efeitos Schwinger estático e oscilatório / Cosmological Analogues of the Static and Oscillatory Schwinger Effect
In this work we study the quantum effects of particle creation in the cosmological context and of the classical electrodynamics. With the studies of the particle creation in constant and oscillatory external electrical fields, the known static and oscillatory Schwinger effects, respectively, it was possible to study the polarization of the quantum vacuum and
Publicado em: 2009
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4. Investigação experimental de metacontingências: separação do produto agregado e da conseqüência individual
The present studys aim was to build an experimental analog of metacontingencies. The experiment started with on adult (P1) working on a computer. At each trial 4 numbers were presented on a row and the participant would type 4 numbers on a row underneath. If the sum on each column (which was not showed) was an odd number, points (exchanged by money at the en
Publicado em: 2008
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5. Genetic diversity and reaction of Passiflora Spp. to M. Incognita and M. Javanica / Diversidade Genética e reação de Passiflora Spp. a Meloidogyne Incognita e a Meloidogyne Javanica
Considering that growing passion fruit has faced problems due to soil pathogens, responsible for significative losses, one objective of this study was to evaluate the reaction of four progenies of sour passion fruit (Passiflora edulis f. flavicarpa), one of sweet passion fruit (Passiflora alata), nine wild species of Passiflora (P. amethystina, P. setacea, P
Publicado em: 2006
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6. Papel do HEME (Ferro protoporfirina IX) na Resposta Inflamatória: mecanismos moleculares envolvidos no recrutamento de neutrófilos
Heme (Iron Protoporphyrin IX), a ubiquitous molecule present in organisms of all kingdoms, is composed of an atom of iron linked to the four ligand groups of porphyrin. As a prosthetic moiety on inactive apo-heme proteins, heme provides a wide range of biological functions determined in part by the polypeptide associated to it. Diseases of increased hemolysi
Publicado em: 2005
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7. Participação do oxido nitrico no desenvolvimento da encefalomielite alergica experimental em ratos
Nitric oxide (NO) is a free radical endogenously synthetised by oxidation of one of the guanidinum nitrogen atoms of the aminoacid L-arginine by molecular oxygen. This biosynthesis is catalised by a family of enzimes generically known as nitric oxide synthases (NOS), which can be inhibited by structural analogs of L-arginine having substituent groups at the
Publicado em: 2001
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8. Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis.
Kinetoplastid hemoflagellates are sensitive to growth inhibition by various purine analogs. In this study the activities of 9-deazainosine (9-DINO), formycin B, and sinefungin were compared in experimental murine Trypanosoma brucei subsp. brucei infections, both singly and in combination with the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornit
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9. Quantitative estimation of the contribution of pyrrolcarboxamide groups of the antibiotic distamycin A into specificity of its binding to DNA AT pairs.
Interaction of DNA with the analogs of the antibiotic distamycin A having different numbers of pyrrolcarboxamide groups and labeled with dansyl was studied. The binding isoterms of the analogs to synthetic polydeoxyribonucleotides were obtained. Analysis of the experimental data leads to the following conclusions: (1) the free energy of binding of the analog
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10. Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.
Nuclease-resistant phosphorothioate analogs of certain oligodeoxynucleotides have been tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Phosphorothioate analogs complementary to HIV sequences, as well as noncomplementary analogs including homooligomers, exhibited potent antiviral activity. The antiviral activit
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11. Efficacy, toxicity, and pharmacokinetics of pentoxifylline and its analogs in experimental Staphylococcus aureus infections.
Pentoxifylline (PTX), a drug that improves neutrophil function in vitro, has been shown to protect neonatal mice against death from experimental staphylococcal infection in vivo at a dose of 50 mg/kg. Using a total of 774 neonatal mice, the effects of various doses of PTX were examined and compared with the effects of three analogs: HWA-448, HWA-285, and A81
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12. A peptide composed of tandem analogs of two myasthenogenic T cell epitopes interferes with specific autoimmune responses
Myasthenia gravis (MG) is a T cell-regulated, antibody-mediated autoimmune disease. Two peptides representing sequences of the human acetylcholine receptor α-subunit, p195-212 and p259-271, were previously shown to stimulate peripheral blood lymphocytes of patients with MG and were found to be immunodominant T cell epitopes in SJL and BALB/c mice, respectiv
The National Academy of Sciences of the USA.