Enzymes Genetic
Mostrando 1-12 de 1281 artigos, teses e dissertações.
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1. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
ABSTRACT Nosocomial bacterial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) is associated with high mortality in neurosurgical patients. There are few reports in the literature on meningitis caused by CRKP. We report two cases of CRKP meningitis after neurosurgery. The K. pneumoniae identification and antimicrobial susceptibility tes
Rev. Inst. Med. trop. S. Paulo. Publicado em: 20/12/2019
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2. Evaluation of the proteomic profiles of ejaculated spermatozoa from Saanen bucks (Capra hircus)
Abstract The Saanen goat breed has been widely explored in breeding programmes; however, there are few reports about the breed’s genetic and molecular composition. Thus, this study aimed to characterize the proteomic profile of spermatozoa from Saanen breeding goats. Five breeding animals with proven fertility were selected, the spermatozoa were collected,
Anim. Reprod.. Publicado em: 25/11/2019
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3. Molecular assessment of Gymnotus spp. (Gymnotiformes: Gymnotidae) fishing used as live baitfish in the Tietê River, Brazil
RESUMO A captura de iscas-vivas para a pesca esportiva constitui uma atividade importante em comunidades de pescadores. As principais espécies utilizadas para este propósito pertencem ao gênero Gymnotus, o qual compreende inúmeras espécies de natureza críptica que dificulta a identificação baseada na morfologia externa. Os objetivos deste trabalho fo
Neotrop. ichthyol.. Publicado em: 25/11/2019
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4. ENDOPHYTIC FUNGI FROM THE BRAZILIAN FLORA AND THEIR EMPLOYMENT IN BIOTRANSFORMATION REACTIONS
The biotransformation reactions are used as a successful alternative to derivatization by the traditional chemistry because they conduct to uncommon reactions, which would hardly be carried out by chemical synthesis. A wide diversity of compounds may be metabolized by fungi, leading to chemical derivatives through selective reactions that work under ecofrien
Quím. Nova. Publicado em: 26/08/2019
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5. High prevalence of CTX-M-1 group in ESBL-producing enterobacteriaceae infection in intensive care units in southern Chile
ABSTRACT Enterobacteria-producing extended-spectrum β-lactamases (ESBL) play an important role in healthcare infections, increasing hospitalization time, morbidity and mortality rates. Among several ESBLs that emerge from these pathogens, CTX-M-type enzymes had the most successful global spread in different epidemiological settings. Latin America presents h
Braz J Infect Dis. Publicado em: 18/07/2019
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6. Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil
Abstract INTRODUCTION: The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil. METHODS: We analyzed 29 E. aerogenes clinical isolates resistant to aminoglycosides. AMEs genes were investig
Rev. Soc. Bras. Med. Trop.. Publicado em: 27/06/2019
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7. Mucopolysaccharidosis: Caregiver Quality of Life
Abstract The mucopolysaccharidoses (MPSs) are a group of rare genetic diseases caused by a deficiency of specific enzymes involved in catabolism of glycosaminoglycans, which causes multisystem abnormalities. Quality of life (QoL) is directly associated with physical, mental, and psychological well-being and with social relationships, including family and fri
J. inborn errors metab. screen.. Publicado em: 19/06/2019
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8. De novo transcriptome analysis of Tibetan medicinal plant Dysphania schraderiana
Abstract Dysphania schraderiana is widely distributed in Lhasa (Tibet, China) and used as a traditional medicine. However, the lack of genetic information hinders the understanding of its physiological processes, such as the biosynthesis of secondary metabolites. Herein, we used Illumina Hiseq4000 platform to sequence the transcriptome of flower and leaf tis
Genet. Mol. Biol.. Publicado em: 13/06/2019
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9. Expert Opinions on Managing Fertility and Pregnancy in Patients With Mucopolysaccharidosis
Abstract The mucopolysaccharidosis (MPS) disorders are rare genetic diseases caused by deficiencies in lysosomal enzymes involved in the degradation of glycosaminoglycans, leading to pulmonary, cardiac and neurological dysfunctions, skeletal anomalies, impaired vision, and/or hearing and shortened life spans. Whereas in the past, few individuals with MPS rea
J. inborn errors metab. screen.. Publicado em: 30/05/2019
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10. Small Molecules: Substrate Inhibitors, Chaperones, Stop-Codon Read Through, and Beyond
Abstract Lysosomal storage disorders are rare genetic disorders due to deficient lysosomal activity, which leads to progressive accumulation of nonmetabolized substrates. Patient’s clinical outcomes have significantly improved since the advent of enzyme replacement therapy, even though this therapeutic approach presents important limitations, such as immun
J. inborn errors metab. screen.. Publicado em: 30/05/2019
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11. The Link Between Lysosomal Storage Disorders and More Common Diseases
Abstract In the last decades, it has become more and more evident that lysosomal storage disorders and common neurodegenerative diseases such as Alzheimer and Parkinson diseases have clinical, neuropathological, and genetic features in common, including lysosomal dysfunction and impaired autophagy. Patients with Gaucher and even carriers of Gaucher disease h
J. inborn errors metab. screen.. Publicado em: 30/05/2019
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12. Phenotype-oriented NGS panels for mucopolysaccharidoses: Validation and potential use in the diagnostic flowchart
Abstract Mucopolysaccharidosis (MPS) are a group of rare genetic disorders caused by deficiency in the activity of specific lysosomal enzymes required for the degradation of glycosaminoglycans (GAGs). A defect in the activity of these enzymes will result in the abnormal accumulation of GAGs inside the lysosomes of most cells, inducing progressive cellular da
Genet. Mol. Biol.. Publicado em: 11/04/2019