Enones
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Ultrasound-Promoted Synthesis, Structural Characterization and in vitro Antimicrobial Activity of New 5-Aryl-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboximidamides
This work aims the synthesis of amidino pyrazolines by the cyclocondensation reaction between 3-(hetero)aryl-1-(2-hydroxyphenyl)enones and aminoguanidine hydrochloride under sonochemical conditions. Thirteen new compounds were synthesized in 15-83% of yield after sonication for 30 min without purification by chromatography. Furthermore, antimicrobial activit
J. Braz. Chem. Soc.. Publicado em: 2020-04
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2. Síntese de 3-Trifluoracetil-1H-pirróis N-Aril Substituídos. / Synthesis of N-Aryl Substituted 3-Trifluoracetyl-1H-pyrroles
Este trabalho apresenta uma nova estratégia sintética simples e versátil para a preparação de uma série inédita de 3-trifluoracetil-1H-pirróis N-aril substituídos. Os pirróis foram obtidos a partir da reação do 3-trifluoracetil-4,5-diidrofurano com aril aminas de fórmula geral ArNH2, sendo Ar= C6H4, 2-MeO(C6H4), 3-MeO(C6H4), 4-MeO(C6H4), 2-Me(C6
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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3. Reações de enonas trialometilsubstituídas com aminas e diaminas: Síntese de análogos do etambutol / Reactions of trihalomethylsubstituted enones with amines and diamines. Synthesis of ethambutol analogues
Uma série de 5,5,5-trifluor-3-metil-(alquilmetilamino)-pentano-1,4-dióis, 5,5,5-trifluor-3-metil-(arilmetilamino)-pentano-1,4-dióis e N,N-bis[5,5,5-trifluor-3-metil-((alquilmetilamino]-pentano-1,4-dióis foram obtidos a partir da reação do 3- trifluoracetil-4,5-diidrofurano com aminas primárias e diaminas e subsequente reação de redução com borohid
Publicado em: 2010
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4. 1-(2,4-dichlorophenyl-1H-pyrazoles: Synthesis, Structural Analysis and Interactions with Cannabinoid Receptors CB1 / 1-(2,4-Diclorofenil)-1H-pirazóis: Síntese, Análise Estrutural e Interação com os Receptores Canabinóides CB1
A method to obtain fourteen enones [EtO2CC(O)C(R2)=C(R1)OR, where R = H, Me; R1 = Pr, Ph, 4-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-NO2C6H4, Fur- 2-yl; R2 = H; R1,R2 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-, 3,4-dihydronaphthalen-2-yl] from acylation of acetals with ethyl oxalyl chloride is reported. The cyclocondensation reaction of these substrat
Publicado em: 2010
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5. USING OF THE IONIC LIQUIDS IN THE SYNTHESIS OF ENONES AND ENAMINONES / UTILIZAÇÃO DE LÍQUIDOS IÔNICOS NA SÍNTESE DE ENONAS E DE ENAMINONAS
The use of ionic liquids 1-butyl-3-methylimidazolium tetrafluorborate ([BMIM] [BF4]) and 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) as catalytic solvent in the synthesis of 1,1,1-trichloro(fluoro)-3-alken-2-onas [CX3C(O)C(R2)=C(R1)OR] from the reaction of enolethers or acetals with acyl halides is reported. The results obtained in the pres
Publicado em: 2009
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6. HETEROCICLIZAÇÃO ENTRE 4-ALCÓXI-1,1,1-TRIFLÚOR-3-ALQUEN-2-ONAS E HIDRAZONAS: METODOLOGIAS SELETIVAS PARA A OBTENÇÃO DE HETEROCICLOS TRIFLUORMETILADOS / HETEROCYCLIZATION OF 4-ALKOXY-1,1,1-TRIFLUORO-3-ALKEN-2-ONES WITH HYDRAZONES: SELECTIVE METHODS FOR THE SYNTHESIS OF TRIFLUOROMETHYLATED HETEROCYCLES
Esta tese descreve diversas metodologias para a síntese regiosseletiva de heterociclos trifluormetilados a partir de 4-alcóxi-1,1,1-triflúor-3-alquen-2-onas e hidrazonas. Na primeira parte do trabalho, uma série de (E)-2-[N-benzil(1-feniletil) idenohidrazino]-4-trifluormetilpirimidinas inéditas foi obtida de maneira convergente a partir da ciclocondensa
Publicado em: 2009
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7. Acilenaminonas: Síntese e Aplicação na Obtenção de Pirazóis, Pirazolo[3,4-d]piridazinonas e Pirazolo[1,5-a]pirimidinas / Acylenaminones: Synthesis and Application in the Obtaining of Pyrazoles, Pyrazolo[3,4-d]pyridazinones and Pyrazolo[1,5-a]pyrimidines
The regioespecific synthesis of a series of 14 N-acylated enaminones (52-88%) from the acylation reaction of secondary -enamino ketones [RC(O)CH=CHNR1R2; R = Ph, 4- FC6H4, 4-NO2C6H4, thien-2-yl, CCl3, CF3; R1 = H; R2 = Bn, Ph, 4-NO2C6H4] with trifluoroacetic anhydride or ethyl oxalyl chloride in pyridine is reported. On the other hand, when tertiary enaminon
Publicado em: 2009
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8. USE OF MICROWAVE IRRADIATION IN THE SYNTHESIS OF ENONES AND 4,5-DIHYDRO-1H-PYRAZOLES TRIHALOMETHYL-SUBSTITUTED / USO DE ENERGIA MICROONDAS NA SÍNTESE DE ENONAS E DE 4,5-DIIDROPIRAZÓIS TRIALOMETIL-SUBSTITUÍDOS
The solvent-free microwave-assisted regiospecific synthesis of a series of 5-trihalomethyl-4,5-dihydro-1H-pyrazole (7 - 10) from the cyclocondensation of 1,1,1- trihalo-4-alkoxy-3-alken-2-ones (5 - 6),[ CX3COC(R)2=C(R)1OR, where X = Cl, F; R = Me, Et; R2 = H, Me and R1 = H, Me, Et, Pr, iso-Pr, Bu, iso-Bu, tert-Bu, iso - Pen, Ph, 4-Me-Ph, 4-MeO-Ph, 4-NO2-Ph,
Publicado em: 2008
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9. REAÇÕES DE CICLOCONDENSAÇÃO DE CIANOACETOIDRAZIDA COM ENONAS HALOMETIL-SUBSTITUÍDAS / CYCLOCONDENSATION REACTIONS OF CYANOACETOHYDRAZIDE WITH HALOMETHYL-SUBSTITUTED ENONES
The synthesis of thirteen 3-(R1), 4-(R2) and 5-(R3)-substituted 1-cyanoacetyl-5-hydroxy-4,5-dihydro-1H-pyrazoles from the cyclocondensation reaction of 4-alkoxy-3-alken-2-ones [R3C(O)C(R2)=C(R1)(OR), where R3 = CF3, CCl3, CHCl2, CO2Et; R2 = H, Me; R1 = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. This reaction was
Publicado em: 2008
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10. Assinalação Estereoquímica de Produtos e Descrição de Mecanismos para Reações de Acoplamento entre α,α- Diclorocetonas e Compostos Carbonílicos Promovidas por Brometo de Índio(I) / Indium(I) Bromide-Mediated Coupling of α,α-Dichloroketones with Carbonyl Compounds: Stereochemical Assignments and Description of Reaction Mechanisms
This work describes our results on the use of indium(I) bromide in Organic Synthesis, namely the reaction mechanisms and stereochemical outcome. Indium enolates, generated from the reaction between indium(I) bromide and α,α-dichloroketones, react with carbonyl compounds. The primary coupling with aldehydes leads to the diastereoselective synthesis
Publicado em: 2007
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11. LÍQUIDOS IÔNICOS: APLICAÇÃO NA SÍNTESE DE β-DIMETILAMINOVINIL CETONAS E NA N-ALQUILAÇÃO DE PIRAZÓIS
Neste trabalho é relatado a síntese de dois líquidos iônicos, tetrafluorborato de 1-alquil-3-metil imidazolíneo, com alquil = butil, octil ([BMIM]BF4 and [OMIM]BF4) e sua utilização como meios reacionais. A adequabilidade dos líquidos iônicos foi avaliada em três reações: (i) síntese de N,N-dimetilenaminonas (RCOCH=CHNMe2, com R = Ph, 4- Me-Ph,
Publicado em: 2007
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12. SULFOXIMIDOVINIL TRIFLUORMETIL CETONAS. OBTENÇÃO E APLICAÇÃO NA SÍNTESE DE AZÓIS E AZINAS DERIVADAS / SULFOXIMIDOVINIL TRIFLUORMETIL CETONAS. OBTENÇÃO E APLICAÇÃO NA SÍNTESE DE AZÓIS E AZINAS DERIVADAS / SULFOXIMIDOVINYL TRIFLUOROMETHYL KETONES. PREPARATION AND APPLICATION IN THE SYNTHESIS OF AZOLES AND AZINES DERIVATIVES / SULFOXIMIDOVINYL TRIFLUOROMETHYL KETONES. PREPARATION AND APPLICATION IN THE SYNTHESIS OF AZOLES AND AZINES DERIVATIVES
This work describes the synthesis of a new series of 4-alkyl(aryl)-4-tetramethylenesulfoximide-1,1,1-trifluorobut-3-en-2-ones (5a-k) by the O,N-exchange reactions of ketones (1a-k) [CF3C(O)CH=CR1R, where R = OMe, OEt; R1 = H, Me, Ph, 4-MePh, 4-MeOPh, 4-BrPh, 4-ClPh, 4-FPh, 4-NO2Ph, 4,4-Bifenil, 1-Naftil] with tetramethylenesulfoximide (4) in absence of solve
Publicado em: 2007