Endopeptidase 24 15
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Expressão da Endopeptidase 24.15 nos órgãos linfóides / Ep24.15 distribution in lymphoid tissue
EP24.15 (endopeptidase 24.15, EC.3.4.24.15) também conhceida por thimet-oligopeptidase é uma metaloendopeptidase que está envolvida no metabolismo de neuropeptídeos, bem como na apresentação de antígenos via MHC-I e mais recentemente como um importante regulador das interações proteína/proteína. O objetivo do presente trabalho é verificar a distr
Publicado em: 2010
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2. Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin
Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha1-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Hemopressin also exerts
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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3. Atividades e expressão de peptidases em ratos tratados cronicamente com L-NAME, um inibidor da biossintese de oxido nitrico, e em ratos espontaneamente hipertensos
Peptidases play an important role in modulating the activity of endogenous peptides in normal and pathological situations. In this work, we investigated the activity and expression of four peptidases (aminopeptidase M - APM, dipeptidyl peptidase IV - DPP IV, metalloendopeptidase 24.15 - MEP 24.15 and neutral endopeptidase 24.11 - NEP 24.11) in rat tissues (a
Publicado em: 2004
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4. Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".
Neutral endopeptidase 24.11, also known as the common acute lymphoblastic leukemia antigen, is a zinc metallopeptidase involved in the inactivation of biologically active peptides, such as the enkephalins and atrial natriuretic peptide. The highly potent radiolabeled inhibitor 2-((3-[125I]iodo-4-hydroxy)phenylmethyl)-4-N-[3-(hydroxyamino-3-oxo-1- phenylmethy
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5. CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides.
Bombesin-like peptides (BLPs) are mitogens for bronchial epithelial cells and small cell lung carcinomas, and increase fetal lung growth and maturation in utero and in organ cultures. BLPs are hydrolyzed by the enzyme CD10/neutral endopeptidase 24.11 (CD10/NEP) which is expressed in bronchial epithelium and functions to inhibit BLP-mediated growth of small c
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6. Cultured human synovial fibroblasts rapidly metabolize kinins and neuropeptides.
Kinins and substance P have been implicated in the pathogenesis of inflammatory arthritis by virtue of their abilities to induce vasodilation, edema, and pain. The relative biological potencies of these peptides in vivo would depend at least in part upon their rates of catabolism in the joint. We hypothesized that human synovial lining cells may regulate int
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7. Evidence for a new role of natriuretic peptides: control of intraocular pressure.
To study the possible physiological role of atrial natriuretic peptide (ANP) in the regulation of intraocular pressure (IOP) the effects of an increase of endogenous ANP within the physiological range induced by the neutral endopeptidase 24.11 (NEP) inhibitor candoxatril were examined. In a single masked placebo controlled trial, seven patients were studied
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8. Cloning and nucleotide sequence of opdA, the gene encoding oligopeptidase A in Salmonella typhimurium.
The opdA gene (formerly called optA) of Salmonella typhimurium encodes a metallopeptidase, oligopeptidase A (OpdA), first recognized by its ability to cleave and allow utilization of N-acetyl-L-Ala4 (E. R. Vimr, L. Green, and C. G. Miller, J. Bacteriol. 153:1259-1265, 1983). Derivatives of pBR328 carrying the opdA gene were isolated and shown to express olig
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9. Sympathetic and parasympathetic interaction in vascular and secretory control of the nasal mucosa in anaesthetized dogs.
1. In dogs anaesthetized with pentobarbitone, electrical stimulation of the parasympathetic nerve fibres to the nasal mucosa evoked frequency dependent increases in both nasal arterial blood flow and nasal secretion. Blood flow was measured using a transonic flow probe placed around the artery. 2. Sympathetic nerve stimulation for 3 min at 10 Hz evoked signi