Drug Plasma Monitoring
Mostrando 1-12 de 66 artigos, teses e dissertações.
-
1. Determinação de docetaxel e metabólitos em plasma por UPLC-MS/MS: desenvolvimento de metodologia analítica e aplicação clínica
A highly sensitive ultra-performance liquid chromatography tandem mass spectrometry method for the determination of Docetaxel and metabolites (M1+M3) in human plasma samples was developed and validated. The method employs a liquid-liquid extraction and a reversed phase separation Acquity® C18 column BEH C18 (150 x 2.1 mm, 1.7 µm). Mobile phase was a mixtur
Quím. Nova. Publicado em: 2020-04
-
2. Diagnostic accuracy of thromboelastometry and its correlation with the HPLC-MS/MS quantification test
The aim of the study was to evaluate the diagnostic accuracy of thromboelastometry for assessing rivaroxaban concentrations. The accuracy of thromboelastometry was compared with the high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method, which is the gold standard for drug plasma monitoring (the reference standard). Forty-six cli
Braz J Med Biol Res. Publicado em: 08/04/2019
-
3. A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS
ABSTRACT A simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of cabozantinib (CZ) in human plasma using cabozantinib-d4 (CZD4) as an internal standard (IS). Chromatographic separation was performed on Xbridge C18, 50 x 4.6 mm, 5 mm column with an isocratic mobile phase compose
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
-
4. Determinação simultânea de topiramato, carbamazepina, fenitoína e fenobarbital em plasma empregando cromatografia a gás com detector de nitrogênio e fósforo
Topiramate and the other frequently co-administered antiepileptic drugs carbamazepine, phenytoin and phenobarbital were determined in 100 µL plasma samples by gas chromatography with nitrogen phosphorus detection (GC-NPD), after a one-step liquid-liquid extraction with ethyl acetate, followed by flash methylation with trimethylphenylammonium hydroxide. Tota
Quím. Nova. Publicado em: 2013
-
5. Desenvolvimento de métodos cromatográficos para análises de antimicrobianos em amostras complexas / Development of chromatographic methods for analysis of antimicrobials in complex samples
This work describes the development of chromatographic methods in combination with microextraction techniques for the determination of parabens in cosmetic and human milk samples and of rifampicin in plasma samples. The design of a molecularly imprinted extraction phase for the solid-phase extraction (SPE) analysis of parabens in human milk samples is also r
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/04/2012
-
6. Monitoração terapêutica do bussulfano oral, após uso de dose teste e durante condicionamento, em pacientes submetidos a transplante alogênico de células-tronco hematopoiéticas / Therapeutic monitoring of oral busulfan, after the use of test dose and during conditioning regimen, in patients undergoing allogeneic hematopoietic stem cell transplantation
Busulfan is an alkylating agent, used for conditioning patients undergoing hematopoietic stem cell transplantation (HSCT). It presents narrow therapeutic range and high variability in pharmacokinetics among patients and doses in the same patient. High plasma concentrations (>1000 ng mL-1) have been related to toxicity, such as sinusoidal obstruction syndrome
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
-
7. Avaliação das técnicas de microextração e eletroforese capilar em meio não aquoso (NACE) para determinação de antidepressivos em amostras de plasma para fins de monitorização terapêutica / Evaluation of microextractions techniques and nonaqueous capillary electrophoresis (NACE) for the determination of antidepressants in plasma samples for therapeutic drug monitoring
A monitorização terapêutica tem sido descrita como um recurso clínico valioso, na individualização do regime de dosagem, de acordo com a concentração do fármaco em amostras de plasma ou soro. O objetivo da monitorização terapêutica é assegurar a eficácia clínica e minimizar os efeitos adversos dos fármacos prescritos na clínica. A química a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
-
8. Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
A method using Liquid Phase Microextraction for simultaneous detection of citalopram (CIT), paroxetine (PAR) and fluoxetine (FLU), using venlafaxine as internal standard, in plasma by high performance liquid chromatography with fluorescence detection was developed. The linearity was evaluated between 5.0 and 500 ng mL-1 (r > 0.99) and the limit of quantifica
Química Nova. Publicado em: 2012
-
9. Desenvolvimento de métodos cromatográficos hifenados (in-tube SPME/LC-FLD e GCxGC/qMS) para análises de fármacos e agrotóxicos em amostras complexas / Development of hyphenated chromatographic methods (in-tube SPME/LC-FLD and GCxGC/MS) for analysis of drugs and pesticides in complex samples.
Determination of trace levels of drugs in biological fluids and multiresidue (contaminants) in food samples is extremely important because this generates valuable data for therapeutic drug monitoring (individualization of dosage regimen) and quality control (food safety), respectively. Because of the demand for analytical methods with high resolution and low
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2011
-
10. Abordagem farmacocinética e farmacodinâmica no monitoramento terapêutico de antimicrobianos em pacientes queimados da unidade de terapia intensiva / Pharmacokinetic and pharmacodynamic approach for antimicrobial therapeutic monitoring in burn patients from the intensive care unit
Introdução: A sepse é a maior causa de morbidade e mortalidade em pacientes queimados, uma vez que profundas alterações ocorrem na farmacocinética de agentes antimicrobianos prescritos para o controle das infecções. Além disso, pacientes queimados podem apresentar quadro de infecção por germes da comunidade, numa fase precoce de internação na UT
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/03/2011
-
11. Monitoring imatinib plasma concentrations in chronic myeloid leukemia
Imatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity. Therapeutic drug monitoring of imatinib is useful for patients that do not present clinical response. There are several analytical methods to measure imatinib in biosamples, which are mainly based on liq
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011
-
12. Desenvolvimento e avaliação da atividade e farmacocinética de nanopartículas lipídicas sólidas contendo a associação de quinina e doxiciclina / Development and evaluation of the activity and pharmacokinetics of solid lipid nanoparticles loaded with the association of Quinine and Doxycycline
Malaria is one of the most devastating tropical diseases caused by intracellular protozoan parasites of the genus Plasmodium. More than 3 billion people live in malarial endemic regions. Five species of Plasmodium (falciparum, vivax, ovale, malariae and knowlesi) cause disease in humans and infection with P. falciparum, the most deadly of these parasites, re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011