Double Stereoinduction
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1. Síntese total dos ácidos pterídicos A e B / Total synthesis of pteridic acids A and B
This work describes the convergent stereoselective synthesis of pteridic acids A and B. Our strategy involved a lithium enolate-mediated aldol reaction between ethyl ketone 5 and aldehyde 4 as the key step to set up C5-C15 fragment favoring 1,2-syn anti-Felkin adduct. As far we know, this is the first example of an aldol reaction between a chiral enolate of
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/12/2009