Dose Effect
Mostrando 1-12 de 5810 artigos, teses e dissertações.
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1. Quais as complicações em mulheres que apresentam diabetes pré-gestacional? É necessário mudar a medicação durante a gestação?
A ocorrência de gestações em mulheres com diabetes pré-gestacional tem aumentado nas últimas décadas, segundo as estatísticas
. O diabetes pré-gestacional pode resultar em complicações graves, sendo que seu efeito começa na fertilização e implantação, afetando de modo particular a organogênese. Esse fato faz aumentar o risco de abort
Núcleo de Telessaúde Mato Grosso do Sul. Publicado em: 12/06/2023
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2. Quais contraceptivos recomendar quando contraindicados os contraceptivos injetáveis mensais combinados?
Nos casos em que contraindicam os medicamentos injetáveis mensais combinados, são indicados os contraceptivos trimestrais ou exclusivos de progesterona injetável, que contêm acetato de medroxiprogesterona com um depósito de 150 mg, um hormônio semelhante ao produzido pelo organismo feminino e consequentemente pela menor ocorrência dos efeitos
Núcleo de Telessaúde Sergipe. Publicado em: 12/06/2023
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3. Comparison of the influence of low dose etomidate and propofol as priming dose on the incidence of etomidate induced myoclonus: a randomised, double-blind clinical trial
Abstract Background: Though hemodynamically stable, etomidate is known for its myoclonus side effect following induction. The main aim of this study is an effective attempt to decrease the incidence of myoclonus with a priming agent. Methods: A prospective, double-blind study was carried out on 50 adults posted for elective surgery. After premedication, pr
Brazilian Journal of Anesthesiology. Publicado em: 2022
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4. The effects of thymoquinone on pancreatic cancer and immune cells
SUMMARY OBJECTIVES: Black cumin is widely used as a spice and as a traditional treatment. The active ingredient in black cumin seeds is thymoquinone. Thymoquinone has shown anticancer effects in some cancers. We planned to investigate its anticancer effect on pancreatic cancer cell lines. METHODS: Thymoquinone chemical component in various doses was prepar
Revista da Associação Médica Brasileira. Publicado em: 2022
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5. Low-dose paclitaxel modulates the cross talk between the JNK and Smad signaling in primary biliary fibroblasts
SUMMARY OBJECTIVE: The objective of this study was to explore the molecular mechanism underlying the occurrence of benign bile duct stricture and the target of low-dose paclitaxel in the prevention of benign bile duct stricture. METHODS: Under the stimulation of transforming growth factor beta 1, the expression of collagen type I and connective tissue grow
Revista da Associação Médica Brasileira. Publicado em: 2022
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6. Low-dose midazolam for anxiolysis for pregnant women undergoing cesarean delivery: a randomized trial
Abstract Introduction: Anxiety and fear are common among pregnant women undergoing cesarean delivery. In addition to psychologically unpleasant, they can elicit endocrine and metabolic changes. Administration of benzodiazepines in this patient group is uncommon and investigation focusing on the topic is rare. This study aimed to determine anxiolysis efficac
Brazilian Journal of Anesthesiology. Publicado em: 2022
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7. The anxiolytic effect of cannabidiol depends on the nature of the trauma when patients with post-traumatic stress disorder recall their trigger event
Objectives: We assessed whether administering cannabidiol (CBD) before recalling the traumatic event that triggered their disorder attenuates anxiety in patients with post-traumatic stress disorder (PTSD). As an exploratory pilot analysis, we also investigated whether this effect depends on the nature of the event (sexual vs. nonsexual trauma). Methods: Thi
Brazilian Journal of Psychiatry. Publicado em: 2022
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8. Pulmonary function and medication effect in mild-stage subjects with Parkinson's disease
Resumo Antecedentes A doença de Parkinson (DP) causa uma série de distúrbios do movimento, muitos deles se desenvolvendo na fase inicial. Objetivo Analisar função pulmonar de pessoas com DP em estágio leve e investigar o efeito da levodopa nesse processo. Métodos Vinte e um participantes com DP idiopática e vinte controles saudáveis foram incluí
Arquivos de Neuro-Psiquiatria. Publicado em: 2022
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9. Antioxidant Effect of Curcumin on the Prevention of Oxidative Damage to the Cochlea in an Ototoxic Rat Model Based on Malondialdehyde Expression
Abstract Introduction Aminoglycoside, as an antimicrobial medication, also has side-effects on the inner ears, bringing about hearing disorders. Curcumin has been proven to be a strong scavenger against various reactive oxygen species (ROS), and the increase in ROS production is considered to play an important role in the process of hearing disorder. Objec
International Archives of Otorhinolaryngology. Publicado em: 2022
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10. Artichoke for biochemistry, histology, and gene expression in obstructive jaundice
SUMMARY OBJECTIVE: This study aimed to evaluate the hepatoprotective effect of artichoke leaf extract (Cynara scolymus) in experimental obstructive jaundice. METHODS: Rats were separated into three groups, namely, sham, control, and artichoke leaf extract. Ischemia was created for 60 min, and then liver tissue and blood samples were taken at the 90th minut
Revista da Associação Médica Brasileira. Publicado em: 2022
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11. A potential syndemic effect associated with symptoms of depression among men who have sex with men
Introduction: Globally, depression rates are high among men who have sex with men (MSM). Multiple factors may interact synergistically to increase this risk. This analysis assessed the prevalence of symptoms of depression among MSM in Brazil and synergistic effects of several factors. Methods: Cross-sectional study conducted in 12 cities using respondent-dr
Brazilian Journal of Psychiatry. Publicado em: 2022
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12. The effect of alpha-2A adrenergic receptor (ADRA2A) genetic polymorphisms on the depth of sedation of dexmedetomidine: a genetic observational pilot study
Abstract Background: The genetic polymorphisms of the alpha-2A adrenergic receptor (ADRA2A), which plays a significant role in sedation, anxiety relief, and antinociception, particularly in dexmedetomidine, may differ in the degree of sedation. This study aimed to investigate the effect of the genetic polymorphisms of ADRA2A (rs11195418, rs1800544, rs248451
Brazilian Journal of Anesthesiology. Publicado em: 2022