Dissolution Test
Mostrando 1-12 de 106 artigos, teses e dissertações.
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1. Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes
The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage. 2-ME-loaded pH-sensitive liposomes (2-ME-PSLs) was prepared containing the lipids, Lipoid E-80 (E-80), cholesteryl hemisuccinate (CHEMS), and cholesterol (CHOL) via thin
Braz. J. Pharm. Sci.. Publicado em: 03/10/2019
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2. Influência da incorporação da HAp e β-TCP no cimento ósseo wollastonita/brushita
RESUMO O elevado número de pacientes com problemas de saúde por doenças ósseas ou traumas tem promovido o desenvolvimento de pesquisas em biomateriais de modo a garantir uma melhor qualidade de vida. Dentre os diversos biomateriais, os cimentos ósseos poliméricos (PMMA) ou cerâmicos (fosfatos e silicatos de cálcio) destacam-se para aplicações em ci
Matéria (Rio J.). Publicado em: 16/09/2019
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3. The Impact of Radiotherapy in the in Vitro Remineralization of Demineralized Enamel
Abstract Objective: To evaluate the impact of radiotherapy on enamel around restorations of glass ionomer cement (GIC) and fluoride tooth paste (FTP). Material and Methods: Eighty enamel blocks were made and randomly distributed into two groups, according to the fluoride therapy, non-fluoride tooth paste (NFTP) and FTP (n=40) and in subgroups in conformity
Pesqui. Bras. Odontopediatria Clín. Integr.. Publicado em: 02/09/2019
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4. Design and evaluation of rhubarb total free anthraquinones oral colon-specific drug delivery granules to improve the purgative effect
Rhubarb is commonly used as a cathartic in Asian countries. However, researchers have devotedextensive concerns to the quality control and safety of rhubarb and traditional Chinese preparations composed of rhubarb due to the instable purgative effect and potential nephrotoxicity of anthraquinones. In this study, we aimed to prepare rhubarb total free anthraq
Braz. J. Pharm. Sci.. Publicado em: 10/07/2019
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5. The development and characterization of Propranolol Tablets using Tapioca starch as excipient
Abstract: Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17–20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization’s List of Essential Medicines. The aim of this work was to
An. Acad. Bras. Ciênc.. Publicado em: 08/04/2019
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6. Effect of Self-Etching Primer Associated to Hydrofluoric acid or Silane on Bonding to Lithium Disilicate
Resumo Avaliar o efeito da combinação de ácido fluorídrico ou silano com o primer autocondicionante de cerâmicas sobre a eficácia da união imediata e após 1 ano de armazenamento em água, padrão de condicionamento e interação química desses tratamentos com o dissilicato de lítio. Um total de 16 blocos CAD/CAM de dissilicato de lítio (DL) foram
Braz. Dent. J.. Publicado em: 04/04/2019
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7. Physicochemical quality profiles of commercial oral tablets and capsules containing lutein – impact of insufficient specific sanitary regulations
Abstract Dietary supplements in many countries such as the USA do not require registration prior to commercialization. The Agência Nacional de Vigilância Sanitária (ANVISA) registers substances with functional properties as foods. Lutein is a carotenoid with antioxidant activity available on the market. However, no regulatory mandates exist to govern the
An. Acad. Bras. Ciênc.. Publicado em: 19/07/2018
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8. Prednisone raw material characterization and formulation development
ABSTRACT Solid dosage forms for oral use, particularly tablets, are the most highly used dosage forms in therapy because they are easily administered, have high productivity and relatively low cost and provide a more stable drug to form a semi-solid net. Numerous parameters influence the quality of the final dosage form. In this study, the dissolution profil
Braz. J. Pharm. Sci.. Publicado em: 08/01/2018
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9. In vitro Monitoring of Macro and Microelements in Multimineral Preparations across Dissolution Profiles by Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES)
In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis in five multimineral preparations from a dissolution test, in accordance with the United States Pharmacopeia (USP 34 method): apparatus 1, 75 rpm and 900 mL of 0.1 mol L-1 HCl. Element releases in all samples (minimum-maximum in %) were: Ca (
J. Braz. Chem. Soc.. Publicado em: 2017-11
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10. Measurement uncertainty of dissolution test of acetaminophen immediate release tablets using Monte Carlo simulations
ABSTRACT Analytical results are widely used to assess batch-by-batch conformity, pharmaceutical equivalence, as well as in the development of drug products. Despite this, few papers describing the measurement uncertainty estimation associated with these results were found in the literature. Here, we described a simple procedure used for estimating measuremen
Braz. J. Pharm. Sci.. Publicado em: 26/10/2017
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11. DETERMINAÇÃO DE ENXOFRE EM SHAMPOO POR ESPECTROFOTOMETRIA UV-VIS: AVALIAÇÃO DE MÉTODOS DE PREPARO DE AMOSTRAS
Dry ashing, dissolution in aqueous medium or wet digestion methods were evaluated for sample preparation of shampoo for the subsequent indirect determination of sulfur by UV-Vis spectrophotometry. Among the sample preparation methods evaluated, microwave-assisted wet digestion using 7 mol L-1 HNO3 was the most suitable method for this purpose. Accuracy of th
Quím. Nova. Publicado em: 2017-08
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12. Development of a Dissolution Test for Fenbendazole-Praziquantel Capsules Using UV-PLS Method
A dissolution test for capsules containing 50 mg of praziquantel and 500 mg of fenbendazole was developed and validated. The optimal conditions were an USP apparatus 2 with paddles rotating at 75 rpm, 900 mL dissolution medium (a mixture of 300 mL of ethanol and 600 mL 0.5 mol L-1 HCl), at 37.0 ± 0.5 °C. Both analytes achieved with sink conditions. A publi
J. Braz. Chem. Soc.. Publicado em: 2017-06