Deoxycorticosterone
Mostrando 1-12 de 98 artigos, teses e dissertações.
-
1. Focus on adrenal and related causes of hypertension in childhood and adolescence: Rare or rarely recognized?
ABSTRACT High blood pressure (BP) is not restricted to adults; children and adolescents may also be affected, albeit less frequently. Aside from unfavorable environmental factors, such as obesity and sedentary life leading to early-onset essential hypertension (HT), several secondary causes must be investigated in the occasional hypertensive child/adolescent
Archives of Endocrinology and Metabolism. Publicado em: 2022
-
2. Classic and current concepts in adrenal steroidogenesis: a reappraisal
ABSTRACT Adrenal steroid biosynthesis and its related pathology are constant evolving disciplines. In this paper, we review classic and current concepts of adrenal steroidogenesis, plus control mechanisms of steroid pathways, distribution of unique enzymes and cofactors, and major steroid families. We highlight the presence of a “mineralocorticoid (MC) pat
Archives of Endocrinology and Metabolism. Publicado em: 2022
-
3. Tension cost correlates with mechanical and biochemical parameters in different myocardial contractility conditions
OBJECTIVES: Tension cost, the ratio of myosin ATPase activity to tension, reflects the economy of tension development in the myocardium. To evaluate the mechanical advantage represented by the tension cost, we studied papillary muscle contractility and the activity of myosin ATPase in the left ventricles in normal and pathophysiological conditions. METHODS:
Clinics. Publicado em: 2012
-
4. Sodium appetite specificity: a possible hormonal contribution. / Especificidade do apetite ao sódio: uma possível contribuição hormonal.
A hipótese do sinergismo entre dois hormônios responsáveis pela conservação de sódio, a aldosterona e a ANG II, explica uma característica do apetite ao sódio, a ingestão de NaCl hipertônico em um animal hipovolêmico. Ingestão de NaCl hipertônico pode ser induzida em ratos normovolêmicos que receberam um tratamento combinado de mineralocorticó
Publicado em: 2006
-
5. Role of sensory nervous system vasoactive peptides in hypertension
The goal of the present research was to elucidate the roles and mechanisms by which the sensory nervous system, through the actions of potent vasodilator neuropeptides, regulates cardiovascular function in both the normal state and in the pathophysiology of hypertension. The animal models of acquired hypertension studied were deoxycorticosterone-salt (DOC-sa
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-09
-
6. Gender differences in vascular expression of endothelin and ET A/ET B receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension
We determined if the increased vascular responsiveness to endothelin-1 (ET-1) observed in male, but not in female, DOCA-salt rats is associated with differential vascular mRNA expression of ET-1 and/or ET A/ET B receptors or with functional differences in Ca2+ handling mechanisms by vascular myocytes. Uninephrectomized male and female Wistar rats received DO
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-09
-
7. Chronic hypertension alters the expression of Cx43 in cardiovascular muscle cells
Connexin43 (Cx43), the predominant gap junction protein of muscle cells in vessels and heart, is involved in the control of cell-to-cell communication and is thought to modulate the contractility of the vascular wall and the electrical coupling of cardiac myocytes. We have investigated the effects of arterial hypertension on the expression of Cx43 in aorta a
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04
-
8. Site of stimulation of aldosterone biosynthesis by angiotensin and potassium
Studies were undertaken to determine what part of the aldosterone biosynthetic pathway is stimulated by angiotensin and potassium. The availability of a method for isolating the early portion of the aldosterone pathway and a new method for measuring plasma deoxycorticosterone permitted the design of experiments to determine whether angiotensin and potassium
-
9. Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone.
Several factors interact to maintain precise control of electrolyte transport in the mammalian cortical collecting duct. We have studied the effects of deoxycorticosterone, arginine vasopressin, and bradykinin on net transepithelial sodium and potassium transport in isolated, perfused rat cortical collecting ducts. Chronic administration of deoxycorticostero
-
10. Comparison of Effects of Deoxycorticosterone and Dexamethasone on Cardiovascular Responses to Norepinephrine *
Cardiovascular responses to graded iv infusions of norepinephrine were observed in 24 dogs that had been treated for 1 week with either placebo, dexamethasone, or deoxycorticosterone. Eight dogs served as control and received daily iv injections of placebo; eight dogs received the mineralocorticoid, deoxycorticosterone; and eight received the glucocorticoid,
-
11. Effect of sodium, deoxycorticosterone and duration of hypertension on pressor responses in rats
1. Enhanced pressor responsiveness to angiotensin II and noradrenaline has been demonstrated in the hypertension that follows deoxycorticosterone (DOC) and salt administration in the rat. The present studies were carried out to assess the importance of factors common to both pressor agents and those specific to individual agents such as receptor availability
-
12. Regulation of rat urinary and renal kallikrein and prekallikrein by corticosteroids.
Rats were adrenalectomized and injected for 7 days with dexamethasone (DEX) or deoxycorticosterone. Kallikrein and prekallikrein were assayed in urine and in a basolateral membrane-enriched fraction. The activities of renin and phospholipase A2 were also determined in the fraction. Adrenalectomy significantly decreased active kallikrein in urine. Administrat