Cytoxicity
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Thermo-Mechanical Properties of P(HB-HV) Nanocomposites Reinforced by Nanodiamonds
Several studies of biodegradable polymers and copolymers have been carried for different applications in the biomedical area. This current study aims to develop a biocomposite to be used as an orthopedic device, using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) P(HB-HV), a biodegradable copolymer, with 94%HB and 6%HV, as matrix; and nanodiamonds (ND) with p
Mat. Res.. Publicado em: 26/06/2017
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2. Seasonal influence and cytotoxicity of extracts, fractions and major compounds from Allamanda schottii
The aim of this research was to evaluate the fractions obtained from the leaf, stem and roots of Allamanda schottii Pohl, Apocynaceae, responsible for the cytotoxicity, using several cell lines. Cytotoxicity was correlated with the season the part of the plant, and the major compounds were assessed. The ethanol extracts of leaves, stems and roots obtained at
Rev. bras. farmacogn.. Publicado em: 2014-10
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3. Fitodesinfecção aplicada a águas na perspectiva da agricultura familiar
As previsões mais otimistas para o mundo no segundo milênio alertam para a escassez de água. Esta terá como origem a redução de volume de água doce aproveitável, o desperdício e poluição das fontes de água. O cloro, usado para a desinfecção, se combina com os resíduos de matéria orgânica remanescente do tratamento da água de consumo formand
Publicado em: 2010
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4. "Avaliação da atividade antimicrobiana e citotóxica in vitro do vinagre a ácido acético: perspectiva na terapêutica de feridas" / In vitro evaluation of antimicrobial and cytotoxicity activities of vinegar and acetic acid: perspectives for wound therapeutics Ribeirão Preto.
One of the concerns of health professionals has been the correct use of chemical products with antimicrobial action on wound therapeutics. This issue represents a serious problem, which is made even worse due to the facts that there is a diversity of options of products, which builds insecurity in regards to which product is more appropriate, and there is an
Publicado em: 2003
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5. Non-Cytoxicity of “Nuclear Antibodies” from Lupus Erythematosus Sera in Tissue Culture *
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6. Interaction of Staphylococcal Enterotoxin B with Cell Cultures I. Effect of Serum and Testing Procedures
The cytopathic effect of staphylococcal enterotoxin B upon mammalian cell cultures is expressed fully only if the cultures are grown in human serum-supplemented media. Little cytotoxicity is seen if the cells are grown in horse serum-supplemented media and none is seen if the cells are grown in calf serum-supplemented media. The cytotoxicity of the toxin is
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7. Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.
Protein in vitro inhibition of thymidylate synthase (5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) by 5-fluoro-2'-deoxyuridylate requires 5,10-methylenetetrahydrofolate. The cytoxicity of 5-fluoro-2'-deoxyuridine towards cultured L1210 mouse leukemia cells is reduced when intracellular reduced folates are depleted, either by limiting
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8. T cells can be cytotoxic without making interleukin 2: a model of separate pathways of induction.
The thoracic duct lymphocytes from rats previously injected with ultraviolet-light-irradiated allogeneic lymphocytes were grown for 4 days with alloantigen, with or without Con A-induced lymphokine factors, and then for 3 days with the lymphokines alone. They were then tested for their cytoxicity and for their capacity to make interleukin 2 (IL-2) in respons
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9. Combination Gene Delivery of the Cell Cycle Inhibitor p27 with Thymidine Kinase Enhances Prodrug Cytotoxicity
Cytoxicity induced by the herpesvirus thymidine kinase (TK) gene in combination with prodrugs is dependent on cell growth and leads to the elimination of genetically modified cells, thus limiting the duration of expression and efficacy of this treatment in vivo. Here, an effort was made to enhance TK/prodrug efficacy by coexpression of a cyclin-dependent kin
American Society for Microbiology.
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10. Bile acids: regulation of apoptosis by ursodeoxycholic acid
Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several liver diseases and colon cancer. Bile acid cytoxicity has been related to membrane damage, but also to nondet
The American Society for Biochemistry and Molecular Biology.
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11. DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines.
To investigate the physiological function of poly(ADP-ribose) polymerase (PARP), we used a gene targeting strategy to generate mice lacking a functional PARP gene. These PARP -/- mice were exquisitely sensitive to the monofunctional-alkylating agent N -methyl- N -nitrosourea (MNU) and gamma-irradiation. In this report, we have analysed the cause of this incr
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12. The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage.
In this study the role of nucleotide excision repair (NER) in protecting mouse embryonic stem (ES) cells against the genotoxic effects of UV-photolesions was analysed. Repair of cyclobutane pyrimidine dimers (CPD) in transcribed genes could not be detected whereas the removal of (6-4) photoproducts (6-4PP) was incomplete, already reaching its maximum (30%) 4