Cytomegaloviruses
Mostrando 1-12 de 38 artigos, teses e dissertações.
-
1. Molecular profile of human cytomegalovirus in bone marrow transplant recipients with active infection / Aspectos moleculares do citomegalovirus humano durante infecção ativa em pacientes submetidos ao transplante de medula ossea
Human Cytomegalovirus (HCMV) remains a significant cause of morbidity in immunocompromised patients, especially in bone marrow transplant recipients. It may manifest severe complications including hepatitis, gastrointestinal disease, and interstitial pneumonitis or as so-called ?HCMV viral syndrome? with fever, leukopenia, and thrombocytopenia. The HCMV may
Publicado em: 2006
-
2. Animal cytomegaloviruses.
Cytomegaloviruses are agents that infect a variety of animals. Human cytomegalovirus is associated with infections that may be inapparent or may result in severe body malformation. More recently, human cytomegalovirus infections have been recognized as causing severe complications in immunosuppressed individuals. In other animals, cytomegaloviruses are often
-
3. Microculture Plaque Assay for Human and Simian Cytomegaloviruses
The plaque assay for human and simian cytomegaloviruses routinely carried out in 60-mm petri dishes (macrocultures) has been adapted for use in microcultures in flat-bottom 16-mm circular wells of disposable plastic trays. Virus titrations and serum neutralization assays carried out in microcultures yielded reproducible results that were identical to those o
-
4. Neutralizing Antibodies to Cytomegaloviruses in Normal Simian and Human Sera
Simian and human sera were examined for neutralizing antibodies to simian and human cytomegaloviruses (CMV). Neutralizing antibody to simian CMV was found in sera from 12 of 12 African green monkeys, 8 of 10 rhesus monkeys, and 7 of 7 baboons captured in the wild. The antibody did not cross-react with human CMV strain AD169 but cross-reacted with human strai
-
5. Analysis and Characterization of the Complete Genome of Tupaia (Tree Shrew) Herpesvirus
The tupaia herpesvirus (THV) was isolated from spontaneously degenerating tissue cultures of malignant lymphoma, lung, and spleen cell cultures of tree shrews (Tupaia spp.). The determination of the complete nucleotide sequence of the THV strain 2 genome resulted in a 195,857-bp-long, linear DNA molecule with a G+C content of 66.5%. The terminal regions of t
American Society for Microbiology.
-
6. Identification and Characterization of a Second Feline Herpesvirus
A feline virus isolate previously reported as adenovirus-like has more recently been identified and characterized as a new feline herpesvirus. This herpesvirus, which appears to be cell associated, has some characteristics of the cytomegaloviruses and has been found to induce chemical crystal formations in infected cell cultures.
-
7. MAREK'S DISEASE HERPES VIRUS: A CYTOMEGALOVIRUS?*
The DNA of herpes viruses associated with Marek's disease of fowl contains 56-57 moles of guanine and cytosine per 100. The composition of its DNA and lack of infectiousness of cell-free preparations suggest that the herpes virus associated with Marek's disease belongs to the herpes virus group B which contains predominantly cytomegaloviruses.
-
8. Size of infectious DNA from human and murine cytomegaloviruses.
Viral DNA was isolated from human and murine cytomegalovirus by equilibrium centrifugation in cesium chloride gradients. The size of the DNA was measured relative to T4 DNA by velocity sedimentation in neutral glycerol gradients, and fractions were assayed for infectious DNA. Infectious murine cytomegalovirus DNA sedimented as a single peak with an estimated
-
9. Multifaceted Evasion of the Interferon Response by Cytomegalovirus
Human cytomegalovirus (HCMV), which infects the majority of the population worldwide, causes few, if any, symptoms in otherwise healthy people but is responsible for considerable morbidity and mortality in immuno-compromised patients and in congenitally infected newborns. The evolutionary success of HCMV depends in part on its ability to evade host defense s
Mary Ann Liebert.
-
10. Effect of rhesus or vervet cytomegalovirus infection of DNA synthesis in untreated and 5-iodo-2'-deoxyuridine-arrested cells.
Infection of permissive cells with either rhesus or vervet cytomegalovirus resulted in suppression of cellular DNA synthesis, only viral DNA was resolved by isopycnic centrifugation after 24 h postinoculation. Infection of 5-iodo-2'-deoxyuridine (IUdR)-arrested cells with either of the simian cytomegaloviruses, however, induced synthesis of cellular DNA of n
-
11. Analysis of antigenic diversity among human cytomegaloviruses by kinetic neutralization tests with high-titered rabbit antisera.
Neutralizing antisera to human cytomegalovirus were produced in rabbits with alkaline-buffered extracts of infected cell cultures. The antibody activity was complement dependent and associated primarily with the 7S immunoglobulin fraction. Antisera with homologous K values greater than 10.00 were shown to be suitable for neutralization kinetic studies and we
-
12. Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses.
The activities of the purine acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) against two human and five animal strains of cytomegalovirus were compared with those of acyclovir. DHPG was significantly more active than acyclovir against all but one (mouse cytomegalovirus) of the strains tested, with 50% effective doses ranging from 5 to 13 m