Crotoxin
Mostrando 13-24 de 35 artigos, teses e dissertações.
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13. ESTUDO DOS EFEITOS RENAIS E VASCULARES DO VENENO DA SERPENTE Crotalus durissus cumanensis E CROTOXINA / RENAL AND VASCULAR EFFECTS FROM Crotalus durissus cumanensis VENOM AND CROTOXIN
Ophidian accidents involving species of the genus Crotalus, are usually serious and frequently fatal due to the frequency of acute renal failure. Unfortunately, there have been few studies of the toxinologic effects of Crotalus durissus cumanensis venom. The renal effects of the venom used in this study were observed by perfusion of isolated kidneys. Infusio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/07/2009
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14. Influência das HSPs (heat shock proteins) e do mTORC-1 (mammalian target of rapamycin complex 1) na regeneração de músculos esqueléticos. / Influence of HSPs (heat shock proteins) and mTORC1 (mammalian target of rapamycin complex 1) in skeletal muscle regeneration.
The goal of this work was to contribute to a better understanding about the intracellular mechanisms involved in skeletal muscle regeneration by studying the influence of heat shock proteins (HSPs) and mTORC1 (mammalian target of rapamycin complex 1) in the muscle regeneration process. The treatment with radicicol (a HSP inductor) in injured muscles induced
Publicado em: 2009
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15. Efeitos do veneno de Crotalus durissus terrificus, da crotoxina e de suas subunidades fosfolipase A2 e crotapotina em monocamadas de células endoteliais em cultura. / Effects of the venom of Crotalus durissus terrificus from crotoxina and its subunits and crotapotina phospholipase A2 in monolayers of endothelial cells in culture.
Crotalus durissus terrificus snake venom (CdtV) and their components induces systemic effects, which interfere with blood vessel system. Endothelial cells (EC) are central elements for haemostasis, regulating blood vessel-wall permeability, blood fluidity and adhesion properties of circulating leukocytes. However, there is no available data on the effects of
Publicado em: 2009
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16. Identification and characterization of Crotalus durissus terrificus venom antitumoral effect and evaluation of its potential use for tumours detection / Identificação e caracterização do efeito antitumoral da peçonha de Crotalus durissus terrificus e avaliação do seu potencial uso na detecção de tumores
The neoplasms basic knowledge is increasing quickly, however, few advances have been reached in clinical therapy and diagnosis of tumours. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase the patients survival. Snake venoms are natural sources of bioactive substances with therapeutically po
Publicado em: 2007
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17. Purification and n-terminal sequencing of two presynaptic neurotoxic PLA2, neuwieditoxin-I and neuwieditoxin-II, from Bothrops neuwiedi pauloensis (jararaca pintada) venom
Two presynaptic phospholipases A2 (PLA2), neuwieditoxin-I (NeuTX-I) and neuwieditoxin-II (NeuTX-II), were isolated from the venom of Bothrops neuwiedi pauloensis (BNP). The venom was fractionated using molecular exclusion HPLC (Protein-Pak 300SW column), followed by reverse phase HPLC (µBondapak C18 column). Tricine-SDS-PAGE in the presence or absence of di
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2007
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18. Efeito do veneno de serpentes Crotalus durissus terrificus e da crotoxina sobre a resposta inflamatória induzida por carragenina em camundongos / Effect of Crotalus durissus terrificus snake venom and crotoxin on inflammatory response induced by carrageenan in mice
O presente estudo investigou o efeito do veneno de Crotalus durissus terrificus (VCdt) e da sua principal fração, crotoxina (ctx) sobre a resposta inflamatória induzida pela carragenina (cg). Foram avaliados o efeito do pré e do pós-tratamento com o VCdt sobre o desenvolvimento do edema de pata, a migração celular para a cavidade peritoneal e a intera
Publicado em: 2007
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19. Structural and pharmacological characterization of new crotalic PLA IND.2 isoforms, from Crotalus durissus cumanensis and Crotalus durissus ruruima venons / Caracterização bioquimica e farmacologica de novas isoformas de PLA IND.2 crotalicas : Crotalus durissus cumanensis e Crotalus durissus ruruima
Na região norte do Brasil a serpente Crotalus durissus ruruima (C.d.r) é responsável por diversos casos de acidentes ofídicos, e é principalmente encontrada próxima à fronteira com a Venezuela e Colômbia. Contudo a Crotalus durissus cumanensis (C.d.c). é outra serpente bastante comum no sul da Venezuela próximo a fronteira com o Brasil. Ambas as se
Publicado em: 2007
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20. Modificações quimicas de fosfolipases A2 procedentes do veneno de Crotalus durissus ruruima e Crotalus durissus cumanensis : estudos dos efeitos cataliticos e farmacologicos / Chemical modifications of phospholipases A2 coming from the poison of Crotalus durissus ruruima and Crotalus durissus cumanesis : studies of the catalytic and pharmacological effects
The serpents of the genus Crotalus include several species widely distributed in the American continent. The poisons crotálicos of the serpents found in Brazil, they present own characteristics. Among the components bioativos, the phospholipases A2 (E.C. 3.1.1.4.) standing out to be the main component, such enzymes are dependents of calcium and hidrolise th
Publicado em: 2007
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21. Isolamento e caracterização de um novo conjunto de serinoproteases com atividade trombina-like e de L-aminoacido oxidase do veneno de Crotalus durissus cascavella / Isolation and characterization of a new serine proteases group with thrombinin-like and L-amino acid oxidase activity from Crotalus durissus cascavella
The use of the isolated toxins from poisons as molecular tools in the understanding of diverse physiological and pathological events has been proved by some works in literature. The serpent Crotalus durissus cascavella is found in the areas of Caatinga Northeast of Brazil, since Maranhão until North of the state of Minas Gerais, and in spite of it hasn?t be
Publicado em: 2006
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22. Efeito da crotapotina na evolução clinica da neurite experimental autoimune (EAN) / Effect of crotapotin on clinical evolution of experimental autoimmune neuritis
Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin which is a fraction of the venom of the rattlesnake Crotalus durissus terrificus, has been described as an antinflammatory that acts on the innate arm of the immune response. Here we have demons
Publicado em: 2006
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23. Neutralização de atividades farmacologicas e enzimaticas de venenos crotalicos perante antivenenos
Crotoxin, the main neurotoxin from venom of the rattlesnakes Crotalus durissus terrificus and Crotalus durissus cascavella, is a protein complex that contains a phospholipase A2 (PLA2) basic and an acid protein, crotapotin. The venom and the purified crotoxin from C. d. cascavella venom were studied with relationship to the neurotoxic and myotoxic effects in
Publicado em: 2005
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24. Estudo comparativo : bioquimico e imunofarmacologico do veneno total, da crotoxina e suas isoformas de crotapotina e PLA2 de crotalus durissus terrificus. C. d. ruruima C.d. cascavella e C. d. collilineatus
This work is divided at three moments, the first one if terrificus deals with a comparative study of the effect of the crude venoms of Crotalus durissus; C. d. ruruima; C. d. cascavella and C. d. collilineatus, as well as of the crotoxin and the crotamine on the junction neuromuscular. Venoms C. d. ruruima was purified for the first time through HPLC in a co
Publicado em: 2005