Cpg
Mostrando 1-12 de 934 artigos, teses e dissertações.
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1. A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides
ABSTRACT Epigenetic modifications might be associated with serum triglycerides (TG) levels. This study aims to systematically review the studies on the relationship between the methylation of specific cytosine-phosphate-guanine (CpG) sites and serum TG levels. This systematic review and meta-analysis study was conducted according to the PRISMA 2020 (Preferre
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Expressão do RNAm e metilação do DNA do gene DKK2 em câncer colorretal
RESUMO CONTEXTO: O câncer colorretal é a terceira neoplasia mais comum no mundo. A metilação de alguns genes nas ilhas CpG podem causar silenciamento gênico e estar envolvida no desenvolvimento de câncer. O potencial papel de DKK2 como um biomarcador no diagnóstico precoce de CCR permanece incerto. OBJETIVO: O objetivo do estudo foi avaliar o perf
Arq. Gastroenterol.. Publicado em: 2021-03
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3. Jaffe-Lichtenstein Syndrome Associated with a Simple Bone Cyst: Unprecedented Rare Case Report
Resumo As denominadas lesões fibro-ósseas dos maxilares constituem um grupo diversificado de desordens nas quais a arquitetura óssea normal é substituída por fibroblastos, fibras colágenas e osso imaturo. Atualmente a Organização Mundial de Saúde reconhece quatro variantes destas lesões, sendo elas: a displasia cemento-óssea, a displasia fibrosa,
Braz. Dent. J.. Publicado em: 2020-09
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4. Saturação de oxigênio e frequência cardíaca em prematuros: comparação entre as técnicas de copo e sonda-dedo
RESUMO Objetivo Avaliar a saturação de oxigênio (SatO2), a frequência cardíaca (FC), o tempo de internação e o peso dos recém-nascidos pré-termos (RNPTs) em Unidade de Terapia Intensiva Neonatal, na oferta de dieta pelas técnicas de alimentação via copo e sonda-dedo, simultaneamente ao aleitamento materno. Método Ensaio clínico randomizado si
CoDAS. Publicado em: 02/12/2019
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5. Comparison of the methodological quality and transparency of Brazilian practice guidelines
Resumo O objetivo deste estudo é comparar as diferenças entre as guias de prática clínica (GPCs) do Ministério da Saúde (MS) e as de outras instituições de saúde brasileiras. Foi realizada uma revisão sistemática das GPCs brasileiras. Foram incluídas GPCs com recomendações para o tratamento farmacológico de doenças crônicas não transmissív
Ciênc. saúde coletiva. Publicado em: 26/09/2019
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6. Methylation status of the PPP1R13L promoter region among lung cancer patients and healthy controls. Analytical cross-sectional study
ABSTRACT BACKGROUND: There is evidence that genetic predisposition and epigenetic alteration (e.g. DNA methylation) play major roles in lung cancer. In our genetic epidemiological studies, rs1970764 in oncogene PPP1R13L was most consistently associated with lung cancer risk. Here, we explored the role of PPP1R13L methylation in lung cancer development. DE
Sao Paulo Med. J.. Publicado em: 29/08/2019
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7. Position-dependent correlation between TBX22 exon 5 methylation and palatal shelf fusion in the development of cleft palate
Abstract: DNA methylation is essential for spatiotemporally-regulated gene expression in embryonic development. TBX22 (Chr X: 107667964-107688978) functioning as a transcriptional repressor affects DNA binding, sumoylation, and transcriptional repression associated with X-linked cleft palate. This study aimed to explore the relationship and potential mechani
An. Acad. Bras. Ciênc.. Publicado em: 19/06/2019
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8. Cytidine-phosphate-guanosine oligodeoxynucleotides in combination with CD40 ligand decrease periodontal inflammation and alveolar bone loss in a TLR9-independent manner
Abstract Local administration of toll-like receptor 9 (TLR9), agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG ODNs), and CD40 ligand (CD40L) can decrease ligature-induced periodontal inflammation and bone loss in wild type (WT) mouse. Objective: This study aimed to explore whether such effect is dependent on TLR9 signaling. Material and Meth
J. Appl. Oral Sci.. Publicado em: 21/05/2018
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9. Effects of Copaiba oil in the healing process of urinary bladder in rats
ABSTRACT Introduction The appropriate closure of the urinary bladder is important to many urologic procedures to avoid the formation of fistulas and strictures by excessive fibrosis. This paper presents the alterations in the bladder healing process of rats after the topical use of Copaiba oil (Copaifera reticulata). Material and Methods Ten male Wistar ra
Int. braz j urol.. Publicado em: 2018-04
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10. Therapeutic drug monitoring of benznidazole and nifurtimox: a systematic review and quality assessment of published clinical practice guidelines
Abstract The pharmacological management of adults with chronic-phase Chagas disease is challenging despite it being the recent focus of extensive research. One of the challenges in the current clinical practice guidelines (CPGs) landscape is the existence of non-evidence-based recommendations for the use of laboratory tests in treatment monitoring. This stud
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-12
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11. Alternatively spliced MEFV transcript lacking exon 2 and its protein isoform pyrin-2d implies an epigenetic regulation of the gene in inflammatory cell culture models
Abstract The function of gene body DNA methylation in alternative splicing, and its relation to disease pathogenesis is not fully elucidated. The gene for familial Mediterranean fever (MEFV) encodes the pyrin protein and contains a 998 bp CpG island, covering the second exon, which is differentially methylated in FMF patients compared to healthy controls. Ou
Genet. Mol. Biol.. Publicado em: 31/08/2017
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12. Role of microRNAs in the treatment of type 2 diabetes mellitus with Roux-en-Y gastric bypass
The aim of this study was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on the peripheral blood microRNAs (miRNAs) of patients with type 2 diabetes mellitus (T2DM). miRNAs are small 20- to 22-nucleotide (nt) noncoding RNAs. They constitute a novel class of gene regulators that negatively regulate gene expression at the post-transcriptional lev
Braz J Med Biol Res. Publicado em: 02/03/2017