Coumarin
Mostrando 13-24 de 178 artigos, teses e dissertações.
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13. Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail
ABSTRACT Euphorbia umbellata (Pax) Bruyns is an easily cultivated shrub, with occurrence in the tropical regions of the American and African continents. Chemical studies have revealed that the latex of this plant is rich in terpene compounds, which are highly toxic to snails Biomphalaria glabrata (Basommatophora: Planorbidae). The aim of this study was to ev
Rev. Inst. Med. trop. S. Paulo. Publicado em: 21/12/2017
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14. Justicia pectoralis, a coumarin medicinal plant have potential for the development of antiasthmatic drugs?
ABSTRACT Justicia pectoralis Jacq., Acanthaceae, is a medicinal plant found Central America. In the Northeast of Brazil, it is popularly known as “chambá” being extensively used in homemade preparations for the treatment of cough, bronchitis and asthma. The species is part of a public phytotherapy program in Brazil entitled “Farmácias Vivas”, Natio
Rev. bras. farmacogn.. Publicado em: 2017-12
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15. Synthesis of New Xanthenes Based on Lawsone and Coumarin via a Tandem Three-Component Reaction
The synthesis of several new xanthenes based on the 1,3-dicarbonyl scaffolds lawsone and coumarin was developed using tandem three-component reactions involving the reagents ortho-hydroxybenzaldehyde, as bifunctional reagent, and an appropriate thiol. These reactions generated two series of para- and ortho-naphthoxanthenes that are structurally related to α
J. Braz. Chem. Soc.. Publicado em: 2017-10
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16. Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
Series of novel coumarin derivatives [I (a–d) and II (a–d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their
Braz J Med Biol Res. Publicado em: 12/09/2017
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17. Development and validation of a stability indicating method for quantification of the sesquiterpene lactone eremantholide C from Lychnophora trichocarpha (Brazilian arnica)
ABSTRACT Pharmacological activities as anti-inflammatory, anti-hyperuricemic, anti-gouty arthritis, antitumor and trypanocidal activities of the aerial parts from Lychnophora trichocarpha (Spreng.) Spreng. ex Sch.Bip., Asteraceae (Brazilian arnica) have already been proved. Eremantholide C is a sesquiterpene lactone and one of the active chemical constituent
Rev. bras. farmacogn.. Publicado em: 2017-08
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18. In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats
ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by t
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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19. Amburana cearensis seed extracts protect PC-12 cells against toxicity induced by glutamate
ABSTRACT Amburana cearensis (Allemão) A.C. Sm., Fabaceae, has been widely studied for its medicinal activities. Many neurodegenerative disorders are caused by oxidative stress, mitochondrial dysfunction, excitotoxicity induced by glutamate and ultimately cell death. This study describes the chemical profile of the ethanolic, hexane, dichloromethane, and eth
Rev. bras. farmacogn.. Publicado em: 2017-04
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20. Phytochemical Profile of Seed Extracts of Plants Typical of the Brazilian Semiarid and their Potential Application in Brackish Water Desalination
The phytochemical profile of typical seeds from semiarid areas of Bahia was explored. The desalination capacity of the seeds discovered in previous studies considered the seeds potentially suitable for desalination of water. Coals composed of crushed seeds of umbu (Spondias tuberosa Arr. Cam.) and umburana (Amburana cearensis A. C. Sm.) were prepared by heat
J. Braz. Chem. Soc.. Publicado em: 2016-09
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21. Application of a Quantitative HPLC-ESI-MS/MS Method for Flavonoids in Different Vegetables Matrices
Plant flavonoids have been increasingly studied for its importance in plant metabolism, inter-species interactions and human health-promoting effects. Each botanical species has a distinct flavonoid profile, and as such, this work aimed to develop and apply a high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (
J. Braz. Chem. Soc.. Publicado em: 2016-03
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22. SÍNTESE DE ÁCIDOS CUMARINO-3-CARBOXÍLICOS E SUA APLICAÇÃO NA SÍNTESE TOTAL DA AIAPINA, CUMARINA E UMBELIFERONA
The synthesis of 3-coumarin-carboxylic acids and their application to the total synthesis of the natural products ayapin, coumarin, and umbeliferone in undergraduate organic chemistry experiments is described herein. The synthetic approach consists of a one-pot cyclization between salyciladehydes and Meldrum's acid in water to produce the above mentioned aci
Quím. Nova. Publicado em: 2015-09
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23. Rapid validated high performance thin layer chromatography method for simultaneous estimation of mangiferin and scopoletin in Canscora decussata (South Indian Shankhpushpi) extract
AbstractMangiferin (polyphenolic xanthone) and scopoletin (phenolic coumarin) are well-studied biological markers present in Canscora decussata(Roxb.) Roem. & Schult., Gentianaceae. The objective set for the present studies is to establish and develop a new, simple, selective, sensitive, and precise high performance thin layer chromatography method for the s
Rev. bras. farmacogn.. Publicado em: 2015-06
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24. UHPLC–MS quantification of coumarin and chlorogenic acid in extracts of the medicinal plants known as guaco (Mikania glomerata and Mikania laevigata)
Abstract In Brazil, Mikania glomerata Spreng. and M. laevigata Sch. Bip. ex Baker, Asteraceae, known popularly as guaco, are widely used for colds and asthma. Although coumarin is adopted as the chemical marker of both species, it was not always detected in M. glomerata, for which chlorogenic acid was identified and quantified instead. The purpose of this st
Rev. bras. farmacogn.. Publicado em: 2015-04