Clozapine
Mostrando 13-24 de 67 artigos, teses e dissertações.
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13. Pharmacological treatment and staging in bipolar disorder: evidence from clinical practice
Objectives:Staging models for medical diseases are widely used to guide treatment and prognosis. Bipolar disorder (BD) is a chronic condition and it is among the most disabling disorders in medicine. The staging model proposed by Kapczinski in 2009 presents four progressive clinical stages of BD. Our aim was to evaluate pharmacological maintenance treatment
Rev. Bras. Psiquiatr.. Publicado em: 12/05/2015
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14. Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
Objective: Schizophrenia is one of the most severe psychiatric disorders, and its current treatment relies on antipsychotic medications with only partial effectiveness. Clozapine is an atypical antipsychotic with a specific profile of action indicated for treatment-resistant schizophrenia. Neuroimaging studies assessing the effects of clozapine could help s
Rev. Bras. Psiquiatr.. Publicado em: 2015-03
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15. A fatal case of ischemic colitis during clozapine administration
Rev. Bras. Psiquiatr.. Publicado em: 2014-12
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16. Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study
Objective: To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment. Method: Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria. Results: Disorganized patients were significantly more treatment-resistant than paranoid p
Rev. Bras. Psiquiatr.. Publicado em: 2013-12
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17. Pharmacogenetics in schizophrenia: a review of clozapine studies
Objectives: Clozapine is quite effective to treat schizophrenia, but its use is complicated by several factors. Although many patients respond to antipsychotic therapy, about 50% of them exhibit inadequate response, and ineffective medication trials may entail weeks of unremitted illness, potential adverse drug reactions, and treatment nonadherence. This re
Rev. Bras. Psiquiatr.. Publicado em: 2013-09
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18. Recent evidence and potential mechanisms underlying weight gain and insulin resistance due to atypical antipsychotics
Objective: Atypical antipsychotics (AAPs) promote obesity and insulin resistance. In this regard, the main objective of this study was to present potential mechanisms and evidence concerning side effects of atypical antipsychotics in humans and rodents. Method: A systematic review of the literature was performed using the MEDLINE database. We checked the
Rev. Bras. Psiquiatr.. Publicado em: 2013-09
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19. Successful re-exposure to clozapine after eosinophilia and clinically suspected myocarditis
Rev. Bras. Psiquiatr.. Publicado em: 2013-03
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20. Clozapina no tratamento da agressividade patológica grave em crianças e adolescentes com transtorno de conduta ou com autismo / Clozapine in the treatment of serious pathological aggression in children and adolescents with conduct disorder or autism
Introdução: Comportamento agressivo pode ser a principal manifestação clínica de Transtorno de Conduta (TC) e Autismo e deve ser cuidadosamente manejado na criança e adolescente, considerando os possíveis prejuízos e a evolução para transtornos psiquiátricos graves na idade adulta. A clozapina se mostrou eficaz no controle da agressividade em cria
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2012
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21. Desenvolvimento, caracterização físico-química e avaliação farmacocinética de nanopartículas auto-organizadas de quitosana / Development, physico-chemical characterization and pharmacokinetic evaluation of self-assembly chitosan nanoparticules
Objectives: Nanoparticles (NP) are useful to modulate the pharmacokinetics (PK) of drugs. The aim of this study was to develop innovative self-assembly nanovesicles (NV) constituted of chitosan and lecithin with isopropyl myristate (IPM) as oil core, able to modify the PK plasma profile of clozapine (CZP) and valproic acid (VPA). Methods: The NV were obtaine
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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22. Grupo de atividades: impacto na qualidade de vida e no ajustamento social de pacientes com diagnóstico de esquizofrenia refratária, medicados com clozapina / Activities Group: impact on quality of life and social adjustment of patients with refractory schizophrenia treated with clozapine
A esquizofrenia é transtorno mental crônico que ocasiona grande impacto na vida do paciente, comprometendo seu ajustamento social e qualidade de vida. Sabe-se que, embora os antipsicóticos atípicos, como a clozapina, contribuam para a melhora de funções cognitivas e socializantes do sujeito, a utilização de estratégias, que combinam medicação e tr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/07/2011
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23. Efeitos neurocomportamentais e neuroquÃmicos da clorpromazina e clozapina no modelo de esquizofrenia induzido pela cetamina em camundongos. / Neurobehavioral and neurochemical effects of chlorpromazine and clozapine in the model of schizophrenia induced by ketamine in mice.
A esquizofrenia à um transtorno mental crÃnico, grave e incapacitante que afeta cerca de 1% da populaÃÃo mundial, cujos sintomas podem ser induzidos pela Cetamina. Neste sentido, hà evidÃncias de que o estresse oxidativo tenha importante papel na patogÃnese desta doenÃa. Desta forma, o presente estudo avaliou os efeitos neurocomportamentais e neuroqu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/05/2011
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24. The role of the cerebellum in schizophrenia: from cognition to molecular pathways
Beside its role in motor coordination, the cerebellum is involved in cognitive function such as attention, working memory, verbal learning, and sensory discrimination. In schizophrenia, a disturbed prefronto-thalamo-cerebellar circuit has been proposed to play a role in the pathophysiology. In addition, a deficit in the glutamatergic N-methyl-D-aspartate (NM
Clinics. Publicado em: 2011