Chronic Mild Stress
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Ayahuasca prevents oxidative stress in a rat model of depression elicited by unpredictable chronic mild stress
ABSTRACT Background: Depression is a highly disabling common mental disorder and, due to its multifactorial nature, the development of effective therapies is challenging and of great relevance. Ayahuasca (AYA), an entheogenic traditional beverage, has emerged as an alternative for antidepressant treatment, however, AYA preclinical and clinical trials are st
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2021-04
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2. Perfil Epidemiológico e Qualidade de Vida dos Estudantes de Medicina Portadores de Hiperidrose Primária
RESUMO Hiperidrose é a produção excessiva de suor pelo corpo, podendo ser primária ou secundária e generalizada ou localizada. As regiões craniofacial, axilar, palmar, dorso, face interna das coxas, plantar são comumente afetadas. A hiperidrose primária (HP), embora seja uma doença benigna, apresenta um eminente impacto negativo na qualidade de vida
Rev. bras. educ. med.. Publicado em: 13/01/2020
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3. Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and 50 mg/kg) significantly increased sucrose consumption a
Braz J Med Biol Res. Publicado em: 19/06/2019
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4. Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials
Objective: Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug. We conducted a systematic review of preclinical and clinical studies addressing the effects of amantadine in animal models of depression and in patients with depressi
Rev. Bras. Psiquiatr.. Publicado em: 11/06/2018
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5. Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients
Brain-derived neurotrophic factor (BDNF) is associated with neuroplasticity and synaptic strength, and is decreased in conditions associated with chronic stress. Nevertheless, BDNF has not yet been investigated in psoriasis, a chronic inflammatory systemic disease that is exacerbated by stress. Therefore, our aim was to determine BDNF plasma levels in psoria
Braz J Med Biol Res. Publicado em: 21/07/2015
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6. Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress
Studies have indicated that early-life or early-onset depression is associated with a 2- to 4-fold increased risk of developing Alzheimers disease (AD). In AD, aggregation of an abnormally phosphorylated form of the tau protein may be a key pathological event. Tau is known to play a major role in promoting microtubule assembly and stabilization, and in maint
Braz J Med Biol Res. Publicado em: 03/03/2014
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7. Animal models as tools to study the pathophysiology of depression
The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression. A basic understanding of the underlying disease processes in depression is lacking; therefore, recreating the disease in animal models is not possible. Popular current models
Rev. Bras. Psiquiatr.. Publicado em: 2013
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8. Deficiência de tiamina e isolamento social afetam aspectos do comportamento motor e níveis centrais de GABA e glutamato
The main phenomenon approached in this study is the motor behavior, evaluated after two different types of environmental stimuli, the consumption of diet deficient in B1 vitamin and/or social isolation. The B1 vitamin, thiamine, is an essential nutrient for the nervous tissue. In previous studies, our research group has shown that the maternal thiamine defic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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9. Effect of repeated restraint stress on memory in different tasks
The present study investigated the effect of repeated stress applied to female rats on memory evaluated by three behavioral tasks: two-way shuttle avoidance, inhibitory avoidance and habituation to an open field. Repeated stress had different effects on rat behavior when different tasks were considered. In the two-way active avoidance test the stressed anima
Publicado em: 2010
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10. Possible relations between Chronic Mild Stress (CMS) and operant performance / Possíveis inter-relações entre a submissão ao Chronic Mild Stree(CMS) e o desempenho operante
Chronic Mild Stress (CMS) é um modelo animal de depressão no qual ratos são submetidos a um protocolo de estressores moderados de forma crônica. Em função disso, o consumo e preferência por água com sacarose diminuem. Tal redução costuma ser considerada uma medida de anedonia, sintoma central da depressão em humanos. Três estudos realizados no La
Publicado em: 2009
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11. The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress / Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
The Chronic Mild Stress (CMS) is an experimental animal model of depression induced by the exposure of rats to a set of moderate and uncontrollable aversive stimuli in a long and uninterrupted period of time. The purpose of this study was to investigate the relationship between performance in variable interval schedule of behavior and exposure to the protoco
Publicado em: 2008
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12. Atherogenic effects of chronic stress on thoracic aorta rats / Efeitos aterogenicos do estresse cronico em aorta toracica de ratos
Metabolic and vascular complications can result in atherosclerosis, which constitutes a great problem of public health, associated to approximately half of the deaths related to the cardiovascular illnesses in the occidental world. Therefore to the establishment of guidelines for treatment and prevention of cardiovascular diseases, it is important to study r
Publicado em: 2008