Chromene
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. New α-Hydroxy-1,2,3-triazoles and 9H-Fluorenes-1,2,3-triazoles: Synthesis and Evaluation as Glycine Transporter 1 Inhibitors
Two series of new compounds containing 1,2,3-triazole moiety were designed as putative GlyT1 inhibitors aiming the discovery of new hits with activity in cognitive disorders. 1,4-Disubstituted α-hydroxy-1,2,3-triazoles were obtained as racemates in moderate to good yields by the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction (click chemistry)
J. Braz. Chem. Soc.. Publicado em: 2020-06
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2. Evaluation of the immunomodulatory effect against splenocytes of Balb/c mice of biflorin obtained from Capraria biflora by a new isolation method
Abstract Biflorin (6,9-dimethyl-3-(4-methylpent-3-en-1-yl) benzo[de]chromene-7,8-dione) is a promising substance that has been increasingly studied in the past decades due to its diverse pharmacological properties (i.e. antitumor, antioxidant, antiinflamatory, antimicrobial activity etc.). Aiming the comprehension of its antitumoral activity we investigated
Rev. bras. farmacogn.. Publicado em: 17/10/2019
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3. Analgesic effect of leaf extract from Ageratina glabrata in the hot plate test
Ageratina glabrata (Kunth) R.M. King & H. Rob., Asteraceae (syn. Eupatorium glabratum Kunth) is widely distributed throughout Mexico and popularly known as "chamizo blanco" and "hierba del golpe" for its traditional use as external analgesic remedy. Though glabrata species has been chemically studied, there are no experimentally asserted reports about possib
Revista Brasileira de Farmacognosia. Publicado em: 02/09/2011
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4. One-pot synthesis of 4H-Chromene and Dihydropyrano[3,2-c]chromene derivatives in hydroalcoholic media
4H-Cromenos e diidropirano[3,2-c]cromenos são obtidos em rendimentos bons a excelentes através de um procedimento simples, brando e eficiente usando poli(N,N'-dibromo-N-etil-benzeno-1,3-dissulfonamida) [PBBS] e N,N,N',N'-tetrabromobenzeno-1,3-dissulfonamida [TBBDA] como catalisadores
Journal of the Brazilian Chemical Society. Publicado em: 2011-05
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5. Antifungal derivatives from Piper mollicomum and P. lhotzkyanum (Piperaceae)
Bioguided fractionation of the extracts from leaves of Piper mollicomum and Piper lhotzkyanum against the fungi Cladosporium cladosporioides and C. sphaerospermum afforded seven bioactive compounds, four being chromenes: methyl 2,2-dimethyl-2H-chromene-6-carboxylate, methyl 8-hydroxy-2,2-dimethyl-2H-chromene-6-carboxylate, 2-methyl-2-[4'-methyl-3'-pentenyl]-
Química Nova. Publicado em: 2007-10
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6. Studies toward the synthesis of jungianol and construction of benzofurans by TTN-mediated ring contraction / Estudos visando à síntese do jungianol e a construção de anéis benzofurânicos utilizando TTN
This thesis describes the studies aiming at the synthesis of jungianol and the construction of benzofuranic rings. In both cases, the key-step is the reaction of thallium(III)-mediated ring contraction. Jungianol is a phenolic sesquiterpene isolated by Bohlmann et al., in 1977, from the species Jungia malvaefolia. The key-step of the synthesis could be the r
Publicado em: 2007
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7. Metabólitos secundários das raízes de Piper crassinervium Kunth (Piperaceae) / Secondary compounds from roots of Piper crassinervium Kunth (Piperaceae)
O extrato bruto (DCM:MeOH 2:1) das raízes de Piper crassinervium foi submetido a fracionamentos cromatográficos resultando no isolamento e identificação de oito substâncias, sendo estas uma flavanona (5,4-diidroxi-7-metoxiflavanona [isosakuranetina]), duas hidroquinonas preniladas (1,4-diidroxi-2-[3,7-dimetil-1-oxo-2-E-6-octadienil]-benzeno e 1,4-diidro
Publicado em: 2006
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8. Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata.
Microbial transformation of lapachol, a naturally occurring naphthoquinone, was carried out by Curvularia lunata (NRRL 2178). The fungus brings about oxidative cyclization of the substrate to dehydro-alpha-lapachone, which was isolated and characterized by nuclear magnetic resonance and mass spectral analyses; its structure was verified by chemical synthesis
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9. BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate KillingS⃞
We examined whether the multikinase inhibitor sorafenib and histone deacetylase inhibitors (HDACI) interact to kill pancreatic carcinoma cells and determined the impact of inhibiting BCL-2 family function on sorafenib and HDACI lethality. The lethality of sorafenib was enhanced in pancreatic tumor cells in a synergistic fashion by pharmacologically achie
American Society for Pharmacology and Experimental Therapeutics.