Caseous Lymphadenitis
Mostrando 13-20 de 20 artigos, teses e dissertações.
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13. Study of sensitivity and specificity of four tests ELISA and utilization of technique of PCR for diagnostic of Lymphadenitis caseous on goats. / Estudo da sensibilidade e especificidade de quatro testes ELISA e utilização da técnica de PCR para diagnóstico de linfadenite caseosa em caprinos.
Caseous lymphadenitis is a chronic disease that mainly affects goats and sheeps. Its etiological agent is a bacteria, Corynebacterium pseudotuberculosis,and the disease is characterized by the development of granulomas in both external and superficial lymphonodes and also in some other organs. The evaluation of the humoral immune response is an important too
Publicado em: 2005
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14. Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis.
An inactive form of the Corynebacterium pseudotuberculosis phospholipase D (PLD) gene was constructed and expressed in a PLD-negative strain (designated Toxminus) of C. pseudotuberculosis. Antibody responses specific to Toxminus and both Toxminus and PLD proteins were detected in sheep following oral administration of Toxminus or Toxminus expressing the PLD
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15. Identification of a novel antigen from Corynebacterium pseudotuberculosis that protects sheep against caseous lymphadenitis.
A 40-kDa protein antigen from Corynebacterium pseudotuberculosis has been identified by application of a strategy that employs locally derived antibody-secreting cells (ASC). ASC probes generated by culture of ASC obtained from the lymph node draining the site of infection showed a specificity restricted to a 40-kDa antigen. Analysis of immunoblots with sequ
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16. Characterization of United Kingdom Isolates of Corynebacterium pseudotuberculosis Using Pulsed-Field Gel Electrophoresis
Caseous lymphadenitis is a chronic suppurative disease caused by Corynebacterium pseudotuberculosis and is responsible for serious economic losses to the sheep and goat industry. Caseous lymphadenitis was first reported for goats in the United Kingdom in 1990 and for sheep in 1991. Recent evidence suggests that the prevalence of the disease within the nation
American Society for Microbiology.
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17. Molecular and biochemical characterization of a protective 40-kilodalton antigen from Corynebacterium pseudotuberculosis.
A 40-kDa protein from Corynebacterium pseudotuberculosis has been previously identified as a protective antigen against ovine caseous lymphadenitis. From genomic DNA libraries of C. pseudotuberculosis, we have cloned and sequenced the 40-kDa protein gene, which was found to contain an open reading frame of 1,137 bp encoding a protein of 379 amino acids. No s
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18. Targeting Improves the Efficacy of a DNA Vaccine against Corynebacterium pseudotuberculosis in Sheep
A large-scale DNA vaccination trial was performed with sheep to investigate whether an antigen targeted by CTLA-4 enhanced and accelerated the humoral immune response. Vaccination with genetically detoxified phospholipase D (ΔPLD) has been shown to be effective, at least partially, against Corynebacterium pseudotuberculosis, the causal agent of caseous lymp
American Society for Microbiology.
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19. Vaccine Potential of Attenuated Mutants of Corynebacterium pseudotuberculosis in Sheep
Corynebacterium pseudotuberculosis, a gram-positive facultative intracellular bacterial pathogen, is the etiological agent of the economically important disease caseous lymphadenitis (CLA) in both sheep and goats. Attenuated mutants of C. pseudotuberculosis have the potential to act as novel vaccines against CLA and as veterinary vaccine vectors. In this rep
American Society for Microbiology.
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20. Attenuation and vaccine potential of aroQ mutants of Corynebacterium pseudotuberculosis.
Corynebacterium pseudotuberculosis, a gram-positive intracellular bacterial pathogen, is the etiological agent of the disease caseous lymphadenitis (CLA) in both sheep and goats. Attenuated mutants of C. pseudotuberculosis have the potential to act as novel live veterinary vaccine vectors. We have cloned and sequenced the aroB and aroQ genes from C. pseudotu