Cardiotonic
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison
Abstract Background: Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a known mechanism that inhibit Na+/K+-ATPase enzyme. However, these poisons have many other molecules
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/04/2019
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2. In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides L.
Abstract The main objective of this study was to demonstrate the antimicrobial potential of the crude extract and fractions of Chenopodium ambrosioides L., popularly known as Santa-Maria herb, against microorganisms of clinical interest by the microdilution technique, and also to show the chromatographic profile of the phenolic compounds in the species. The
Braz. J. Microbiol.. Publicado em: 2018-06
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3. A review on phytochemical, ethnomedical and pharmacological studies on genus Sophora, Fabaceae
Sophora is a genus of the Fabaceae family, contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands, in the family Fabaceae of herbaceous (Sophora flavescens Aiton) to trees (Sophora japonica L.). More than fifteen species in this genus have a long history of use in traditional Chin
Rev. bras. farmacogn.. Publicado em: 03/04/2012
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4. Efeito modulador da ouabaína no sistema imunológico
Initially known as a cardiotonic steroid capable to inhibit the Na+/K+ATPase, ouabain was identified as an endogenous substance present in human plasma, produced by the adrenal, pituitary and hypothalamus and can interfere with various aspects of immune response. In this study, which aimed to study the modulating effect of ouabain on the immune system in viv
Publicado em: 2011
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5. Efeitos de esteróides cardiotônicos endógenos na função renal de ratos. / Effects of endogenous cardiotonic steroids in the function kidney of rats.
Bufodienolídeos são cardiotônicos esteróides estruturalmente relacionados aos cardenolídeos usualmente utilizados na clínica como, por exemplo, a digoxina. Alguns bufodienolídeos podem ser detectados no plasma e urina de mamíferos e sua significância pato/fisiológica tem sido alvo de intensa investigação recentemente. Estudos demonstram que a pro
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/10/2009
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6. ANÁLISE MORFOANATÔMICA DAS FOLHAS E CASCA DE Aspidosperma nitidum BENTH. E Aspidosperma marcgravianum WOODSON (APOCYNACEAE) COM ABORDAGEM FARMACOGNÓSTICA E ETNOFARMACOLÓGICA
In this present paper was realized a ethnopharmacological study with Aspidosperma nitidum and A. marcgravianum known as carapanaúba at Nossa Senhora Aparecida (Silves-AM) community and Urubuí (Presidente Figueiredo-AM) community. However, the livers at those communities know and indicates just A. nitidum using it for treatment of liver and stomach diseases
Publicado em: 2009
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7. AVALIAÇÕES FITOQUÍMICA E FARMACOLÓGICA DAS SEMENTES DE Pterodon emarginatus Vogel / Phytochemistry and pharmacological evaluation of Pterodon emarginatus Vogel seeds
Pterodon emarginatus Vogel (Leguminosae), popularly Known as sucupira-branca or faveiro, is native plant, easily found all over central Brazil. The infusion of its bark leaves and seeds are effective action anti-rheumatic, analgesic and antiinflammatory. The present work available the phytochemistry and pharmacological potential of P. emarginatus Vogel seeds
Publicado em: 2008
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8. Positive inotropic effect of the metanolic extract from the chloroficea algae Bryopsis pennata (Chlorophyta, Caulerpales) / Ação inotrópica positiva do extrato metanólico da alga clorofícea Bryopsis pennata (Chlorophyta, Caulerpales)
As algas marinhas representam uma rica fonte de compostos bioativos, algumas delas precurssoras de ferramentas farmacológicas e de substâncias potencialmente úteis para o desenvolvimento de novos fármacos. A macroalga Bryopsis pennata , Cloroficea pertencente à ordem Caulerpales, sin. Bryopsidales é uma espécie tropical encontrada em diversos costões
Publicado em: 2008
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9. Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and
Química Nova. Publicado em: 2002-12
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10. Cardiotonic agent milrinone stimulates resorption in rodent bone organ culture.
The cardiotonic agent amrinone inhibits bone resorption in vitro. Milrinone, an amrinone analog, is a more potent cardiotonic agent with lower toxicity. In contrast to amrinone, milrinone stimulated resorption in cultures of neonatal mouse calvaria and fetal rat limb bones. Threshold doses were 0.1 microM in calvaria and 0.1 mM in limb bones; maximal stimula
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11. Alkylation of a brain transport adenosinetriphosphatase at the cardiotonic steroid site by strophanthidin-3-haloacetates.
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12. Na+ channels as sites of action of the cardioactive agent DPI 201-106 with agonist and antagonist enantiomers.
This paper shows the interaction of the cardiotonic agent 4-[3-(4-diphenylmethyl-1-piperazinyl)-2-hydroxypropoxy]-1H-indole- 2-carbonitrile (DPI 201-106) and its optic enantiomers R-DPI (205-429) and S-DPI (205-430) with the Na+ channel of a variety of excitable cells. Voltage-clamp experiments show that DPI 201-106 acts on neuroblastoma cells and rat cardia