Calcium Entry Blocker
Mostrando 1-12 de 34 artigos, teses e dissertações.
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1. Efeito da nifedipina por via sistêmica na analgesia pós-operatória induzida pelo sufentanil intratecal em pacientes submetidas à lipoabdominoplastia em caráter ambulatorial / Effect of nifedipine in a systemic way in postoperative analgesia induced by intrathecal sufentanil in patients undergoing ambulatory lipoabdominoplasty
BEZERRA DE LIMA, BJS. Effect of nifedipine in a systemic way in postoperative analgesia induced by intrathecal sufentanil in patients undergoing ambulatory lipoabdominoplasty. 2011. 72 f. Tese (Doutorado) Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo Calcium channel voltage-gated play an important role in transmitting nociceptive impuls
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/05/2011
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2. Estudo da interação da veratrina com o musculo esqueletico por metodos histoquimicos, ultraestruturais e bioquimicos
Veratrine, a commercial extract from the South and Central America plant Schoenocaulon officinale (Liliaceae), activates voltage-dependent Na + channels to produce persistent depolarization and an increase in sodium ion penneability in muscle fibers or nerves. The aim of this study was to investigate the effects of the veratrine aIkaloid on skeletal muscle o
Publicado em: 2000
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3. Alterações cardiovasculares induzidas pelo veneno da aranha (Phoneutria nigriventer) em ratos anestesiados
The changes induced in the mean arterial blood pressure (MABP) of anaesthetised rats following the administration of armed spider (Phoneutria nigriventer) venom have been investigated. The intravenous injection of Phoneutria nigriventer venom (PNV; 0.1 mg/kg) evoked a brief and reversible decrease in the MABP whereas a higher dose of venom (0.3 mg/kg) caused
Publicado em: 1996
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4. Charge movement in skeletal muscle fibers paralyzed by the calcium-entry blocker D600.
We report measurements of nonlinear charge movement in frog skeletal muscle fibers paralyzed by the calcium-entry blocker [Schwartz, A. & Taira, N., eds. (1983) Circ. Res. 52, Part II, Number 2, 1-181.] D600 (methoxyverapamil, recently renamed gallopamil). Nonlinear charge movement was not seen in such fibers, suggesting that the drug severs the link between
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5. Ryanodine-sensitive calcium stores involved in neurotransmitter release from sympathetic nerve terminals of the guinea-pig.
1. Intracellular and focal extracellular recording techniques were used to study neurotransmitter release mechanisms in postganglionic sympathetic nerve terminals in the guinea-pig isolated vas deferens. 2. High concentrations of the selective N-type calcium channel blocker omega-conotoxin GVIA abolished the release of the neurotransmitter ATP evoked by trai
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6. Targeting Chronic and Neuropathic Pain: The N-type Calcium Channel Comes of Age
Summary: The rapid entry of calcium into cells through activation of voltage-gated calcium channels directly affects membrane potential and contributes to electrical excitability, repetitive firing patterns, excitation-contraction coupling, and gene expression. At presynaptic nerve terminals, calcium entry is the initial trigger mediating the release of neur
The American Society for Experimental neuroTherapeutics.
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7. Stable and functional expression of the calcium channel alpha 1 subunit from smooth muscle in somatic cell lines.
Voltage-activated calcium channels are membrane spanning proteins that allow the controlled entry of Ca2+ into the cytoplasm of cells. The principal channel forming subunit of an L-type calcium channel is the alpha 1 subunit. Transfection of Chinese hamster ovary (CHO) cells with complementary DNA encoding the calcium channel alpha 1 subunit from smooth musc
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8. Relation between muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells.
1. The action of carbachol, which activates muscarinic receptors, was studied in single patch-clamped cells where free internal calcium concentration in the cell (Cai2+) was estimated using the emission from the dye Indo-1. Cells were dialysed with potassium-free caesium solution to block any Ca(2+)-activated K(+)-current. 2. Carbachol applied to the cell ev
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9. On the mechanism of parathyroid hormone stimulation of calcium uptake by mouse distal convoluted tubule cells.
PTH stimulates transcellular Ca2+ absorption in renal distal convoluted tubules. The effect of PTH on membrane voltage, the ionic basis of the change in voltage, and the relations between voltage and calcium entry were determined on immortalized mouse distal convoluted tubule cells. PTH (10(-8) M) significantly increased 45Ca2+ uptake from basal levels of 2.
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10. Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells.
Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal convoluted tubule (MDCT) cells to determine the mechanism underlying the dissociation of sodium from calcium transport and the stimulation of calcium absorption induced by thiazide diuretics. Control rates o
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11. Calcium channels involved in synaptic transmission at the mature and regenerating mouse neuromuscular junction.
1. The involvement of the different types of voltage-dependent calcium channels (VDCCs) in synaptic transmission at the mature and newly formed mammalian neuromuscular junction was studied by evaluating the effects of L-, P/Q- and N-type VDCC antagonists on transmitter release in normal and reinnervating levator auris preparations of adult mice. 2. Nerve-evo
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12. Nifedipine facilitates neurotransmitter release independently of calcium channels
Nifedipine, a drug used for treatment of hypertension and angina, exerts its effect by calcium channel blockade and nitric oxide production. We report here a previously uncharacterized action of nifedipine on central synaptic transmission that may partially explain its side effects. Nifedipine causes a long-lasting facilitation of tetrodotoxin-insensitive sp
The National Academy of Sciences.