Bufadienolides
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Chemical Constituents and Cytotoxic Activity of Rhinella jimi (Anura: Bufonidae)
Rhinella jimi toads (Stevaux, 2002) belong to the Bufonidae family, are endemic in the Brazilian Northeast and are commonly found during rainy periods. In general, amphibians of this family have in their poisons different metabolites that show a diversity of pharmacological activities. The isolation and identification of these compounds are of great importan
J. Braz. Chem. Soc.. Publicado em: 2021-05
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2. Preparative separation and purification of bufadienolides from ChanSu by high-speed counter-current chromatography combined with preparative HPLC
Eight bufadienolides were successfully isolated and purified from ChanSu by high-speed counter-current chromatography (HSCCC) combined with preparative HPLC (prep-HPLC). First, a stepwise elution mode of HSCCC with the solvent system composed of petroleum ether - ethyl acetate - methanol - water (4:6:4:6, 4:6:5:5, v/v) was employed and four bufadienolides, t
Quím. Nova. Publicado em: 2013
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3. Efeitos de esteróides cardiotônicos endógenos na função renal de ratos. / Effects of endogenous cardiotonic steroids in the function kidney of rats.
Bufodienolídeos são cardiotônicos esteróides estruturalmente relacionados aos cardenolídeos usualmente utilizados na clínica como, por exemplo, a digoxina. Alguns bufodienolídeos podem ser detectados no plasma e urina de mamíferos e sua significância pato/fisiológica tem sido alvo de intensa investigação recentemente. Estudos demonstram que a pro
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/10/2009
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4. Lucibufagins: Defensive steroids from the fireflies Photinus ignitus and P. marginellus (Coleoptera: Lampyridae)*
Feeding tests with thrushes (Hylocichla spp.) led to the isolation of three novel steroid pyrones from fireflies (Photinus ignitus and P. marginellus) responsible, in part at least, for the unpalatability of these insects to the birds. The term lucibufagin is coined for these steroidal pyrones. The closest known relatives of lucibufagins are the familiar car
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5. The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker
Bufonid anurans of the genus Atelopus contain both steroidal bufadienolides and various guanidinium alkaloids of the tetrodotoxin class. The former inhibit sodium-potassium ATPases, whereas the latter block voltage-dependent sodium channels. The structure of one guanidinium alkaloid, zetekitoxin AB, has remained a mystery for over 30 years. The structure of
National Academy of Sciences.
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6. Specific 12β-Hydroxylation of Cinobufagin by Filamentous Fungi
Biotransformation of natural products has great potential for producing new drugs and could provide in vitro models of mammalian metabolism. Microbial transformation of the cytotoxic steroid cinobufagin was investigated. Cinobufagin could be specifically hydroxylated at the 12β-position by the fungus Alternaria alternata. Six products from a scaled-up ferme
American Society for Microbiology.
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7. Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive α1 Na+-K+-ATPase
Endogenous Na+ pump inhibitors are thought to play important (patho)physiological roles and occur in two different chemical forms in the mammalian circulation: cardenolides, such as ouabain, and bufadienolides, such as marinobufagenin (MBG). Although all α Na+-K+-ATPase isoforms (α1-4) are sensitive to ouabain in most species, in rats and mice the ubiquito
American Physiological Society.