Brouwer
Mostrando 13-24 de 26 artigos, teses e dissertações.
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13. Routine screening of children returning home from the tropics: retrospective study
British Medical Journal.
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14. Original Papers: EXPERIMENTAL ANATOMICAL INVESTIGATIONS CONCERNING THE PROJECTION OF THE RETINA ON THE PRIMARY OPTIC CENTRES IN APES.
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15. The sweetness-inducing effect of miraculin; behavioural and neurophysiological experiments in the rhesus monkey Macaca mulatta
1. The gustatory effects of miraculin, the sweetness-inducing protein from the miracle fruit Synsepalum dulcificum, was studied in the rhesus monkey, Macaca mulatta.
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16. The role of the excision-repair enzymes in mutation-induction by cis-Pt(NH3)2Cl2.
Mutation induction by cis-Pt(NH3)2Cl2 (cisplatin) has been shown to be absent in E.coli strains carrying a deletion of the uvrB gene (1). This suggested that excision-repair, which is normally thought to be error-free, is involved in mutation induction with cisplatin. Here, the role of the excision repair enzymes UvrA, UvrB and UvrC is investigated using E.c
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17. The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma
The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 t
BioMed Central.
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18. Suppression of Transgene Silencing by Matrix Attachment Regions in Maize: A Dual Role for the Maize 5′ ADH1 Matrix Attachment Region
Matrix attachment regions (MARs) are DNA sequences that bind an internal nuclear network of nonhistone proteins called the nuclear matrix. Thus, they may define discrete gene-containing chromatin loops in vivo. We have studied the effects of flanking transgenes with MARs on transgene expression levels in maize callus and in transformed maize plants. Three MA
American Society of Plant Biologists.
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19. Effect of pKM101 on cell killing and specificity of mutation induction by cis-diaminedichloroplatinum(II) in Escherichia coli K-12.
Cell killing and mutation induction in the lacI gene of Escherichia coli by cis-Pt(NH3)2Cl2 were studied in cells with different repair capacities, with and without pKM101. The presence of the plasmid pKM101 made repair-proficient cells more susceptible to killing by cis-Pt(NH3)2Cl2 and strongly enhanced mutation induction by that compound. Both effects were
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20. Changes in corticospinal facilitation of lower limb spinal motor neurons after spinal cord lesions.
The projections from the cortex to the motor neurons of lower limb muscles were examined in 33 normal subjects and 16 patients with incomplete spinal cord lesions. Corticospinal neurons were excited by transcranial magnetic stimulation and the effects on single spinal motor neurons determined from peristimulus time histograms (PSTHs) of single tibialis anter
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21. Hydroxamate-Stimulated O2 Uptake in Roots of Pisum sativum and Zea mays, Mediated by a Peroxidase 1: Its Consequences for Respiration Measurements
Low concentrations of salicylhydroxamic acid (<5 millimolar) stimulate O2 uptake in intact roots of Pisum sativum. We demonstrate that the hydroxamate-stimulated O2 uptake does not reside in the mitochondria. We also show that the hydroxamate-stimulated O2 uptake is due to the activation of a peroxidase catalyzing reduction of O2. This peroxidase, which can
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22. Base-pair substitution hotspots in GAG and GCG nucleotide sequences in Escherichia coli K-12 induced by cis-diamminedichloroplatinum (II).
Cell killing and mutation induction by cis- and trans-Pt(NH3)2Cl2 in Escherichia coli were examined by studying forward mutagenesis in the lacI gene in cells with different repair capacities. Survival experiments showed that repair-proficient cells were slightly more sensitive for the cis isomer than for the trans isomer, whereas repair-deficient RecA and Uv
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23. Autoantibodies directed to novel components of the PM/Scl complex, the human exosome
The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the human homologue of the yeast exosome, which is an RNA-processing complex. Our aim was to assess whether, in addition to targeting the known autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently identified components of the PM/Scl complex. The prevale
BioMed Central.
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24. Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates.
The structure-activity relationships of a series of compounds related to the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) oxathiin carboxanilide have been described (R. W. Buckheit, Jr., T. L. Kinjerski, V. Fliakas-Boltz, J. D. Russell, T. L. Stup, L. A. Pallansch, W. G. Brouwer, D. C. Dao, W. A. Harrison, R. J. Schultz, J. P. Bader, and S. S.