Bronchi Hyperreactivity
Mostrando 1-2 de 2 artigos, teses e dissertações.
-
1. Putative involvement of the thyroid hormones in hyperreactivity development induced by antigenic challenge with ovalbumin on ovalbumin-sensitized rat isolated tracheae. / Participação dos hormônios tireoideanos no desenvolvimento de hiperreatividade induzida pelo desafio antigênico com ovalbumina em traquèias isoladas de ratos sensibilizados
In other to verify the influence of thyroid hormones on the tracheal hyperreactivity development, euthyroid, hypothyroid (propiltiouracil [PTU] - p.o. 0.05% w/v, 4 weeks) or hyperthyroid (L-tiroxine [T4] 0.5 mg/kg s.c.,7 or 9 days) male rats (200 - 250 g) were sensitized to ovalbumine (OVA) and, 14 days later, challenged with OVA inhalation, (1 mg/ml, follow
Publicado em: 2005
-
2. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.
To investigate the contribution of interleukin-4 (IL-4) to airway inflammation in vivo and to explore directly its relationship to airway reactivity, we created transgenic mice in which the murine cDNA for IL-4 was regulated by the rat Clara cell 10 protein promoter. Expression was detected only in the lung and not in thymus, heart, liver, spleen, kidney, or