Brain Circulation
Mostrando 25-36 de 98 artigos, teses e dissertações.
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25. Angiographically occult arteriovenous malformations of the brain
Six patients with cerebral arteriovenous malformations which did not show any pathological circulation at angiography are described. Computed tomogram appearances of such lesions may be difficult to distinguish from tumours. The need for surgical exploration in localised high attenuation lesions of uncertain nature is stressed, and the literature is reviewed
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26. Cerebral air embolism resulting from invasive medical procedures. Treatment with hyperbaric oxygen.
The introduction of air into the venous or arterial circulation can cause cerebral air embolism, leading to severe neurological deficit or death. Air injected into the arterial circulation may have direct access to the cerebral circulation. A patent foramen ovale provides a right-to-left shunt for venous air to embolize to the cerebral arteries. The ability
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27. The renin—angiotensin system in drinking and cardiovascular responses to isoprenaline in the rat
1. We investigated the role of the renin—angiotensin system in isoprenaline-induced drinking in the rat. Captopril, an inhibitor of angiotensin-converting enzyme, was used to block the synthesis of angiotensin II either in the circulation alone or in the brain as well.
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28. On the role of sensitised T-lymphocytes in the pathogenesis of multiple sclerosis
Peripheral blood lymphocytes from 24 out of 26 patients with clinically well-defined multiple sclerosis in remission showed sensitisation to multiple sclerosis brain extracts as assayed by enhancement of the early erythrocyte rosette test. Such an increase in the number of early rosettes was not found when the lymphocytes of multiple sclerosis patients were
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29. 19-Hydroxylation of androgens in the rat brain.
Aromatization of androgens in the central nervous system is linked with sexual differentiation of the brain and, thus, determines the nature of sexual behavior and the control of gonadotropin secretion. The process of aromatization, as determined in the human placenta, proceeds through two successive hydroxylations at C-19, the products of which are then vir
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30. In vivo stability and kinetics of absorption and disposition of 3' phosphopropyl amine oligonucleotides.
Development of oligonucleotide derivatives as therapeutic agents requires an understanding of their pharmacokinetic behavior. The in vivo disposition and stability of a prototype of such compounds are reported here. The compound studied, a relatively G-rich 38 base 3' phosphopropyl amine oligonucleotide (TFO-1), was cleared from the circulation with a half-l
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31. Kinetics of thiamine transport across the blood-brain barrier in the rat.
1. By measurement of the rate of disappearance of injected tracer thiamine from the bloodstream, a programme for the continuous injection of thiamine at a variable rate has been devized by which a steady raised level can be achieved rapidly and maintained in the circulation. By this means the flux of radioactive thiamine across the blood-brain barrier has be
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32. Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation
A fundamental discovery of modern human brain imaging with positron-emission tomography that the blood flow to activated regions of the normal human brain increases substantially more than the oxygen consumption has led to a broad discussion in the literature concerning possible mechanisms responsible for this phenomenon. Presently no consensus exists. It is
The National Academy of Sciences.
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33. Brain damage and mortality in dogs following pulsatile and non-pulsatile blood flows in extracorporeal circulation
In a series of 20 dog experiments, total cardiac bypass was followed by a high rate of mortality during the first 12 postoperative hours. Only five dogs survived for one week, but a further three dogs were perfuse-fixed after shorter periods of survival. All dogs developed pulmonary alveolar haemorrhages and seven of the eight perfuse-fixed brains exhibited
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34. Brain damage in dogs immediately following pulsatile and non-pulsatile blood flows in extracorporeal circulation
The brains of dogs subjected to total cardiac bypass were examined for early signs of ischaemic nerve cell changes. Diffuse nerve cell changes were found immediately following two- and three-hour non-pulsatile perfusions but not following pulsatile perfusions of the same durations. The nerve cell changes found in the brains were acute cell swelling and early
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35. Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier
Elimination of amyloid-β peptide (Aβ) from the brain is poorly understood. After intracerebral microinjections in young mice, 125I-Aβ1-40 was rapidly removed from the brain (t1/2 ≤ 25 minutes), mainly by vascular transport across the blood-brain barrier (BBB). The efflux transport system for Aβ1-40 at the BBB was half saturated at 15.3 nM, and the maxi
American Society for Clinical Investigation.
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36. RNA Interference and Nonviral Targeted Gene Therapy of Experimental Brain Cancer
Summary: The human epidermal growth factor receptor (EGFR) plays an oncogenic role in solid cancer, including brain primary and metastatic cancers. Transvascular nonviral gene therapy in combination with EGFR-RNA interference (RNAi) represents a new therapeutic approach to silencing oncogenic genes in solid cancers. This is achieved with pegylated immunolipo
The American Society for Experimental NeuroTherapeutics.