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Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. O efeito da tarefa cognitiva sobre a estabilidade postural na distonia cervical
RESUMO Introdução: A distonia cervical (DC) é a forma mais comum de distonia focal. Não se sabe exatamente se posturas anormais da cabeça na DC causam problemas de equilíbrio. A execução de duas tarefas simultaneamente é situação comum da vida cotidiana. Objetivo: Avaliar a estabilidade postural (EP) em pacientes com DC e o efeito da tarefa co
Arq. Neuro-Psiquiatr.. Publicado em: 2020-09
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2. Surtos de botulismo hídrico tipo C em búfalos (Bubalus bubalis) na região amazônica
RESUMO: Botulismo é uma intoxicação causada por neurotoxinas botulínicas (BoNTs). Os sorotipos C e D de BoNTs estão envolvidos em surtos de botulismo em bovídeos em vários países. Apesar do elevado número de búfalos em todo o mundo, o real impacto do botulismo em búfalos não é conhecido; pois não é uma doença de notificação obrigatória no
Pesq. Vet. Bras.. Publicado em: 2017-07
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3. Bronquiolite e asma: o próximo passo,
J. Pediatr. (Rio J.). Publicado em: 2017-06
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4. The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
ABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven da
Acta Cir. Bras.. Publicado em: 2016-11
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5. Botulinum toxin type A on cutaneous flap viability in diabetic and tobacco-exposed rats
PURPOSE:To investigate the effect of Botulinum toxin A (BoNTA) on skin flap viability in healthy, tobacco-exposed and diabetic rats.METHODS: Ninety male Wistar rats (250-300g) were randomly divided into six groups: control+saline (C1), control+BoNTA (C2), tobacco-exposed+saline (T1), tobacco-exposed+BoNTA (T2) diabetes+saline (D1) and diabetes+BoNTA (D2). A
Acta Cir. Bras.. Publicado em: 2015-09
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6. Dor miofascial dos músculos da mastigação e toxina botulínica
JUSTIFICATIVA E OBJETIVOS: Disfunção temporomandibular (DTM) abrange um conjunto de alterações craniofaciais, que pode envolver a articulação temporomandibular (ATM), os músculos da mastigação e/ou estruturas associadas. As DTM musculares são as mais frequentes e um dos seus subtipos compreende a dor miofascial. A toxina botulínica tipo A (BoNT A)
Rev. dor. Publicado em: 2013-03
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7. Fluorigenic Substrates for the Protease Activities of Botulinum Neurotoxins, Serotypes A, B, and F
The seven botulinum neurotoxins (BoNTs) are zinc metalloproteases that cleave neuronal proteins involved in neurotransmitter release and are among the most toxic natural products known. High-throughput BoNT assays are needed for use in antibotulinum drug discovery and to characterize BoNT protease activities. Compared to other proteases, BoNTs exhibit unusua
American Society for Microbiology.
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8. Plasma membrane localization signals in the light chain of botulinum neurotoxin
Botulinum neurotoxin (BoNT) is a potent biological substance used to treat neuromuscular and pain disorders. Both BoNT type A and BoNT type E display high-affinity uptake into motor neurons and inhibit exocytosis through cleavage of the synaptosome-associated protein of 25 kDa (SNAP25). The therapeutic effects of BoNT/A last from 3 to 12 months, whereas the
National Academy of Sciences.
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9. Gene probes for identification of the botulinal neurotoxin gene and specific identification of neurotoxin types B, E, and F.
A polymerase chain reaction method was developed for the specific detection of the botulinum neurotoxin (BoNT) gene of Clostridium botulinum. Degenerate oligonucleotide primers, designed from the nucleotide sequence of the heavy chain of the BoNT gene, amplified a specific fragment of approximately 1.1 kb from strains of C. botulinum toxin types A, B, E, F,
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10. Genetic Analysis of Type E Botulinum Toxin-Producing Clostridium butyricum Strains†
Type E botulinum toxin (BoNT/E)-producing Clostridium butyricum strains isolated from botulism cases or soil specimens in Italy and China were analyzed by using nucleotide sequencing of the bont/E gene, random amplified polymorphic DNA (RAPD) assay, pulsed-field gel electrophoresis (PFGE), and Southern blot hybridization for the bont/E gene. Nucleotide seque
American Society for Microbiology.
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11. Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity
Clostridium botulinum neurotoxins (BoNTs), the most potent toxins known, disrupt neurotransmission through proteolysis of proteins involved in neuroexocytosis. The light chains of BoNTs are unique zinc proteases that have stringent substrate specificity and require exceptionally long substrates. We have determined the crystal structure of the protease domain
National Academy of Sciences.
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12. Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody
The botulinum neurotoxins (BoNTs) cause the paralytic human disease botulism and are one of the highest-risk threat agents for bioterrorism. To generate a pharmaceutical to prevent or treat botulism, monoclonal antibodies (mAbs) were generated by phage display and evaluated for neutralization of BoNT serotype A (BoNT/A) in vivo. Although no single mAb signif
National Academy of Sciences.