Biological Safety Studies
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. BIOLOGICAL THERAPY PENETRATION FOR INFLAMMATORY BOWEL DISEASE IN LATIN AMERICA: CURRENT STATUS AND FUTURE CHALLENGES
RESUMO CONTEXTO: A introdução dos agentes anti-TNF representou um marco no tratamento da doença de Crohn (DC) e da recocolite ulcerativa (RCU), com maior eficácia e segurança quando comparado ao tratamento convencional. No entanto, ainda existem desafios significativos na América Latina para facilitar o acesso dos agentes biológicos a médicos e pac
Arq. Gastroenterol.. Publicado em: 30/09/2019
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2. Phytochemical analysis of Juglans regia oil and kernel exploring their antinociceptive and anti-inflammatory potentials utilizing combined bio-guided GC–FID, GC–MS and HPLC analyses
ABSTRACT Juglans regia L., Juglandaceae, is broadly used due to its immunomodulatory effects, potentials in protecting against many sever-disorders, and high safety-profile. The aim of this work is to make a phytochemical analysis of J. regia oil and kernel exploring their antinociceptive and anti-inflammatory potentials utilizing combined bio-guided gas chr
Rev. bras. farmacogn.. Publicado em: 2018-06
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3. Biologic therapy for psoriasis - still searching for the best target
Psoriasis is a chronic skin disease that results from the complex interaction between genetic and environmental factors. Over the last few decades, scientific evidence has redirected the focus of therapeutic studies to the immunologic pathways underlying its pathogenesis. This led to the biologic boom that we are currently experiencing, with the development
An. Bras. Dermatol.. Publicado em: 2014-04
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4. PROTETORES SOLARES À BASE DE FILTROS INORGÂNICOS: DESENVOLVIMENTO E CARACTERIZAÇÃO
The inorganic sunscreens represented mainly by titanium dioxide (TiO2) and Zinc Oxide (ZnO), were classified as inert particles, therefore, they are pointed out as the best way to protect the skin against the harmful effects of ultraviolet radiation (UV). However, recent studies suggest that these particles have several stability problems that may lead to a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/01/2012
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5. Mesilato de gemifloxacino : desenvolvimento e validação de métodos analíticos, teste de dissolução e estudo de estabilidade
A análise de fármacos é fundamental nas diversas fases do desenvolvimento farmacêutico, tais como em estudos de formulação, estabilidade e controle de qualidade do produto. O mesilato de gemifloxacino (MGF), liberado para uso clínico no Brasil em novembro de 2006 com o nome comercial de Factive®, é uma fluorquinolona indicada para o tratamento da ex
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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6. Biological, systemic and reproductive evaluation in Wistar rats feed on genetically modified soybean resistant to the glyphosate. / Respostas biológica, sistêmica e reprodutiva de ratos Wistar alimentados com soja geneticamente modificada resistente ao glifosato
The most cultivated genetically modified plant in Brazil is the soybean [Glycine max (L.) Merr.] resistant to the systemic herbicide glyphosate. There are 12.3 millions of cultivated hectares. This soybean was obtained through the introduction of the gene that codes for the 5-enolpyruyilshikimic-acid3-phosphate synthase enzyme, (EPSPS, E.C 2.5.1.19, CP4), of
Publicado em: 2009
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7. Receptores de hormônios da tireóide: estudos computacionais, ressonância plasmônica de superfície e ensaios celulares / Thyroid hormone receptor: computational studies, surface plasmon resonance and cell based assays
The thyroid hormone receptors (TRs) are transcriptional factors involved in cell differentiation, development, metabolism and physiological function of most tissues. Many lines of evidence show that several pharmacological actions of TRs might be beneficial in medical therapy, specially those mediated by TR that target important medical conditions like obesi
Publicado em: 2008
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8. Efeitos de inibidores de proteinases de soja em organismos não-alvo associados à cultura da cana-de-açúcar / Effects of soybean proteases inhibitors on non-target organisms associated to sugarcane
Genes of plants expressing insect proteinase inhibitors have been introduced into plants for pest control. Proteases inhibitors are present in plant tissues, mainly in seeds, and act in response to predators and pathogens. The Bowman-Birk type and Kunitz type of serine proteases inhibitors (PI) from soybean seeds are been used to increase resistance of sugar
Publicado em: 2008
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9. "Terapia endodôntica associada à irradiação do canal radicular com laser de diodo: avaliação térmica, morfológica, microbiológica e da infiltração marginal apical" / Endodontic root canal therapy usindg diode laser irradiation: thermographic, morphological, microbiological and marginal apical leakge studies
The aim of this study was to evaluate the effects of diode laser irradiation associated with endodontic therapy. The aspects analyzed were: temperature rise at the external root surface, morphological changes at the dentine root walls, apical marginal leakage after root sealing, and microbiological reduction after laser irradiation. The temperature rise in i
Publicado em: 2007
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10. Framework de Kernel para um sistema de segurança imunologica
The alarming growth in the quantity and the sophistication of the attacks that threaten modem computer systems shows the need for new, more efticient security systems. In nature, there is a biological system that accomplishes this task with a remarkable efticiency: the human immune system. Not only this system is capable of assuring the survival of a human b
Publicado em: 2006
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11. Estudo da esterilização por plasma de acoplamento indutivo e análise comparativa com esterilização por óxido de etileno / Study of sterilization by Inductively coupled plasma and comparison with sterilization by ethilene oxyde
The gas Plasma sterilization technology has been emerging as an alternative to conventional low temperature processes since the advent of new therapies using heat sensitive materials in the healthcare field is greater than ever. The gas Plasma mechanism of action includes the generation of actives species by an electrical discharge, which is able to promote
Publicado em: 2006
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12. Indução artificial da apoptose como medida de segurança em terapia genica
In order to apply gene therapy to clinical practice, it is necessary to develop a system establishing biological efficiency and safety in case of toxic effects.The erythropoietin gene (EPO) can be used in the treatment of chronic anemia, however in vivo studies have revealed that toxic effects, such as thrombosis and fatal polycythemia, are frequent due to u
Publicado em: 2005