Biological Modeling
Mostrando 1-12 de 203 artigos, teses e dissertações.
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1. Faith-based intervention, change of religiosity, and abstinence of substance addicts
Objective: To investigate the effects of developing religiosity on abstinence of substance abuse among recovering addicts in a faith-based and a secular-based treatment program. Methods: Religiosity of recovering addicts was measured using the 38-item Brief Multidimensional Measure of Religiousness/Spirituality at three points in time: at initiation of subs
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Automated Framework for Developing Predictive Machine Learning Models for Data-Driven Drug Discovery
The increasing availability of extensive collections of chemical compounds associated with experimental data provides an opportunity to build predictive quantitative structure-activity relationship (QSAR) models using machine learning (ML) algorithms. These models can promote data-driven decisions and have the potential to speed up the drug discovery process
J. Braz. Chem. Soc.. Publicado em: 2021-01
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3. Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides
The pyrazole core has been recognized by their biological properties and included in the synthesis of modern agrochemicals. Part of these studies consists of making structural modifications to pesticides for commercial purposes to increase efficacy. In this article, we present the synthesis of four new pyrazol-4-carboxamide 8a-8d derivatives (PCD), through a
J. Braz. Chem. Soc.. Publicado em: 2020-09
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4. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain
Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcranial magne
Braz. J. Psychiatry. Publicado em: 2020-08
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5. SISTEMAS PEDOGEOMORFOLÓGICOS NA INTERPRETAÇÃO DA EVOLUÇÃO DE PAISAGENS QUATERNÁRIAS EM CLIMAS TROPICAIS ÚMIDOS
Resumo As relações entre solo e relevo são constantes em paisagens de climas tropicais e subtropicais úmidos, devido aos espessos mantos regolíticos resultantes de acelerado intemperismo físico, químico e biológico. A investigação dos sistemas pedogeomorfológicos merece destaque em análises sistêmicas, que objetivam o estudo da gênese e dos pro
Mercator (Fortaleza). Publicado em: 09/12/2019
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6. A Mathematical Model on the Immune System Role in Achieving Better Outcomes of Cancer Chemotherapy
RESUMO A incidência de doenças neoplásicas mostra que a busca por tratamentos mais eficazes contra o câncer ainda é necessária. Além dos tratamentos padrão, como quimioterapia e radioterapia, novas modalidades de tratamento têm sido focadas nos recentes avanços na imunologia. Como pouco tem sido discutido sobre as implicações biológicas da quimi
TEMA (São Carlos). Publicado em: 16/09/2019
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7. Fair Value of Biological Assets: An Interdisciplinary Methodological Proposal
Resumo Dada a complexidade de se mensurar o fair value de ativos biológicos agrícolas, que geralmente não possuem um mercado ativo e são dependentes de fatores climáticos, ambientais e biológicos, surge a necessidade de uma visão interdisciplinar que considere outros inputs além dos econômicos e contábeis. Nesse sentido, o presente ensaio teórico
Rev. adm. contemp.. Publicado em: 15/08/2019
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8. In silico prediction of the functional and structural consequences of the non-synonymous single nucleotide polymorphism A122V in bovine CXC chemokine receptor type 1
Resumo O presente estudo objetivou avaliar se o polimorfismo causal A122V promove alterações nas propriedades funcionais e estruturais da proteína receptora de quimiocina CXC do tipo 1 (CXCR1) de bovino Bos taurus por análises in silico. Duas sequências de aminoácidos da CXCR1 bovina foram selecionadas a partir do banco de dados UniProtKB/Swiss-Prot:
Braz. J. Biol.. Publicado em: 18/04/2019
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9. Contact phenomena modeling in biological structures on the example of the implant-bone
Abstract The work presents modeling of interface phenomena in biological structures. Selected ways of numerical modeling of phenomena at the boundary of two materials by means of FEM methods are discussed. The work focuses on phenomena related to biological structures and their mutual interactions. Using an example of an implant-bone system, various techniqu
Lat. Am. j. solids struct.. Publicado em: 14/03/2019
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10. Fatores associados à evolução do peso de crianças em programa de suplementação alimentar
RESUMO: Identificar a influência dos fatores socioeconômicos, dos cuidados e da alimentação sobre o estado nutricional infantil são importantes para avaliação e direcionamento de políticas públicas baseadas em intervenções nutricionais. Foram investigados os fatores sociodemográficos e biológicos associados à saída de crianças da faixa de bai
Rev. bras. epidemiol.. Publicado em: 21/02/2019
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11. 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
Abstract Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological scr
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/10/2018
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12. VALIDATION OF COMPUTATIONAL METHODS APPLIED IN MOLECULAR MODELING OF CAFFEINE WITH EPITHELIAL ANTICANCER ACTIVITY: THEORETICAL STUDY OF GEOMETRIC, THERMOCHEMICAL AND SPECTROMETRIC DATA
Models validation in QSAR, pharmacophore, docking, and others, can ensure the accuracy and reliability of future predictions in design and selection of molecules with biological activity. In these study, the caffeine molecule was optimized using Hartree-Fock (HF) and Density Functional Theory (DFT/B3LYP) methods, with seven basis sets. Linear correlation dat
Quím. Nova. Publicado em: 2018-07