Biologic Markers
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Expressão de CD44 e CD24 em carcinomas mamários ductais invasivos de acordo com análise dos subtipos moleculares e sua relação com fatores prognósticos / CD44 and CD24 expression in ductal invasive breast carcinomas, classified by molecular subtypes and its association with prognostic factors
Carcinomas de mama são heterogêneos e consistem de diversos tipos celulares. Perfis de expressão gênica usando DNA microarrays identificaram quatro subtipos moleculares fundamentais baseados na expressão de receptores hormonais (estrógeno e progesterona) e de fator de crescimento epidérmico (HER2) (luminal tipo A, luminal tipo B, tumores expressando s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/09/2011
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2. Impacto do uso rápido dos betabloqueadores sobre a mortalidade e remodelamento ventricular na insuficiência cardíaca avançada / Impact of rapid beta-blockers therapy on mortality and ventricular remodeling in advanced heart failure
Fundamento: A terapia com betabloqueadores é fundamental para o tratamento da insuficiência cardíaca congestiva. Entretanto, apesar dos dados que documentam os benefícios dos betabloqueadores, a otimização da dose desses medicamentos durante a hospitalização ainda não foi testada. Objetivos: Avaliar a segurança da efetividade do betabloqueio rápid
Publicado em: 2011
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3. Flavins promote changes in the extracellular matrix, signal transduction, antioxidant enzymes and metalloproteinases during osteoblast differentiation / Flavinas promovem mudanças na matriz extracelular, vias de transdução de sinal, enzimas antioxidantes e metaloproteinases durante a diferenciação de osteoblastos
Riboflavin (Rb-Vitamin B2) is the precursor of essential flavocoenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes participate in numerous enzymatic processes dependent on electron transfer reactions that occur in energyproducing, biosynthetic, and detoxifying and electron-scavenging pathways. Increase dietary ribofla
Publicado em: 2009
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4. Biomarcadores funcionais e histológicos associados à exposição do peixe prochilodus lineatus ao óleo diesel
Considerando-se o elevado número de acidentes com petróleo e seus derivados que vem ocorrendo atualmente no Brasil e a escassez de trabalhos sobre os efeitos destes contaminantes nos organismos aquáticos, testes de toxicidade voltados para a avaliação dos efeitos destes poluentes em espécies de peixes de ambientes neotropicais são necessários e urgen
Publicado em: 2006
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5. Clinical Trials For Cytoprotection In Stroke
Summary: To date, many cytoprotective drugs have reached the stage of pivotal phase 3 efficacy trials in acute stroke patients. (Table 1) Unfortunately, throughout the neuroprotective literature, the phrase “failure to demonstrate efficacy” prevails as a common thread among the many neutral or negative trials, despite the largely encouraging results enco
The American Society for Experimental NeuroTherapeutics.
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6. Biologic effects after a single dose of poly(I):poly(C12U) in healthy volunteers.
Poly(I):poly(C12U) (mismatched double-stranded RNA; atvogen), an interferon inducer, is active against human immunodeficiency virus in vitro. To determine the extent and duration of the biologic effects of poly(I):poly(C12U), we administered a single dose of the drug to healthy volunteers in a randomized, double-blind, placebo-controlled 2-week crossover stu
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7. Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems
Hu proteins are mammalian embryonic lethal abnormal visual system (ELAV)-like neuronal RNA-binding proteins that contain three RNA recognition motifs. Although Drosophila ELAV is required for the correct differentiation and survival of neurons, the roles played by the Hu genes in the mammalian nervous system remain largely unknown. To explore the in vivo fun
The National Academy of Sciences.
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8. Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds.
Neu differentiation factor (NDF) is a 44-kD glycoprotein which was isolated from ras-transformed rat fibroblasts and indirectly induces tyrosine phosphorylation of the HER-2/neu receptor via binding to either the HER-3 or HER-4 receptor. NDF contains a receptor binding epidermal growth factor (EGF)-like domain and is a member of the EGF family. There are mul
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9. Host-determined differences in expression of surface marker characteristics on human and simian lymphoblastoid cell lines transformed by Epstein-Barr virus.
In an attempt to account for differences in the biologic behavior of Epstein-Barr virus in different primate species, we studied lymphocyte surface markers on primary and transformed cells. Among primary leukocytes, the distribution of cells with characteristics of bone-marrow-derived cells (B cells) was similar in humans, wooly monkeys, and cotton-top marmo
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10. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. We investigated global gene expression in surgical samples of brain tumors. Gene expression profiling revealed large differences between normal brain samples and tumo
National Academy of Sciences.
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11. Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
For most associations of common single nucleotide polymorphisms (SNPs) with common diseases, the genetic model of inheritance is unknown. The authors extended and applied a Bayesian meta-analysis approach to data from 19 studies on 17 replicated associations with type 2 diabetes. For 13 SNPs, the data fitted very well to an additive model of inheritance for
Oxford University Press.
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12. Primary ciliary dyskinesia: a report from ATS 2001, May 18–23, San Francisco
Primary ciliary dyskinesia (PCD) is a genetic disorder of abnormal ciliary structure and function that leads to defective mucociliary clearance, resulting in oto-sino-pulmonary disease, and infertility. The disease is currently under intense investigation by a number of research groups worldwide. At the recent American Thoracic Society meeting in San Francis
BioMed Central.