Barriers To Entry
Mostrando 13-24 de 36 artigos, teses e dissertações.
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13. Lack of Functional Receptors Is the Only Barrier That Prevents Caprine Arthritis-Encephalitis Virus from Infecting Human Cells
Barriers to replication of viruses in potential host cells may occur at several levels. Lack of suitable and functional receptors on the host cell surface, thereby precluding entry of the virus, is a frequent reason for noninfectivity, as long as no alternative way of entry (e.g., pinocytosis, antibody-dependent adsorption) can be exploited by the virus. Oth
American Society for Microbiology.
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14. Temperature Effects on Soybean Imbibition and Leakage
As a part of an analysis of the nature of chilling injury to seeds, measurements were made of the initial linear rates of water entry into and solute leakage out of cotyledons of soybean at various temperatures. Arrhenius plots were approximately linear for water entry into both living and dead cotyledons, with the slope (and activation energy) for entry int
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15. Computer-based physician order entry: the state of the art.
Direct computer-based physician order entry has been the subject of debate for over 20 years. Many sites have implemented systems successfully. Others have failed outright or flirted with disaster, incurring substantial delays, cost overruns, and threatened work actions. The rationale for physician order entry includes process improvement, support of cost-co
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16. Increasing consolidation in healthcare markets: what are the antitrust policy implications?
OBJECTIVE: To discuss the implications of the rapid transformation of the healthcare financing and delivery system for competition, social welfare, and antitrust policy. PRINCIPAL FINDING: Horizontal and vertical consolidations can enhance efficiency but can also be anticompetitive in markets characterized by entry barriers. RECOMMENDATION: Active enforcemen
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17. Binding pathway of retinal to bacterio-opsin: a prediction by molecular dynamics simulations.
Formation of bacteriorhodopsin (bR) from apoprotein and retinal has been studied experimentally, but the actual pathway, including the point of entry, is little understood. Molecular dynamics simulations provide a surprisingly clear prediction. A window between bR helices E and F in the transmembrane part of the protein can be identified as an entry point fo
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18. An organizational field approach to resource environments in healthcare: comparing entries of hospitals and home health agencies in the San Francisco Bay region.
OBJECTIVE: To draw together insights from three perspectives (health economics, organizational ecology, and institutional theory) in order to clarify the factors that influence entries of providers into healthcare markets. A model centered on the concept of an organizational field is advanced as the level of analysis best suited to examining the assortment a
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19. The Human Immunodeficiency Virus Type 1 gag Gene Encodes an Internal Ribosome Entry Site
Several retroviruses have recently been shown to promote translation of their gag gene products by internal ribosome entry. In this report, we show that mRNAs containing the human immunodeficiency virus type 1 (HIV-1) gag open reading frame (ORF) exhibit internal ribosome entry site (IRES) activity that can promote translational initiation of Pr55gag. Remark
American Society for Microbiology.
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20. Medication errors: prevention using information technology systems
Given the high frequency of medication errors with resultant patient harm and cost, their prevention is a worldwide priority for health systems.Systems that use information technology (IT), such as computerized physician order entry, automated dispensing, barcode medication administration, electronic medication reconciliation, and personal health records, ar
Blackwell Science Inc.
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21. Effects of histamine, ethanol, and a detergent on exudation and absorption across guinea pig airway mucosa in vivo.
This study examined effects of three substances that cause mucosal provocation (histamine, ethanol, and the detergent dioctylsodium sulphosuccinate (DOSS] on the flux of solutes across airway vascular mucosal barriers in anaesthetised guinea pigs. The inward flux was assessed as absorption of iodine-131 labelled albumin (MW 69,000) from the tracheobronchial
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22. Differential expression in human and mouse cells of human immunodeficiency virus pseudotyped by murine retroviruses.
Expression of cell surface CD4 influences susceptibility of cells to human immunodeficiency virus (HIV) infection; however, some CD4-positive human and mouse cells are still resistant to HIV infection. To search for mechanisms of resistance to HIV independent of CD4 expression, HIV expression was studied in human and mouse cells normally resistant to HIV inf
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23. Towards a small animal model for hepatitis C
Hepatitis C virus (HCV) causes chronic liver disease and affects an estimated 3% of the world's population. Options for the prevention or therapy of HCV infection are limited; there is no vaccine and the nonspecific, interferon-based treatments now in use are frequently ineffective and have significant side effects. A small-animal model for HCV infection wou
Nature Publishing Group.
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24. Lipidic Systems for In Vivo siRNA Delivery
The ability of small-interfering RNA (siRNA) to silence specific target genes not only offers a tool to study gene function but also represents a novel approach for the treatment of various human diseases. Its clinical use, however, has been severely hampered by the lack of delivery of these molecules to target cell populations in vivo due to their instabili
Springer US.